Tissue Engineering and Therapeutic Advances in Musculoskeletal Medicine

描述（由申请人提供）：本提案旨在支持肌肉骨骼科学组织工程领域的研究项目。它旨在丰富罗彻斯特大学转化研究伙伴关系的基础设施。该合作伙伴关系是在骨科和生物医学工程系之间建立的，是医学院和工程与应用科学学院之间的桥梁。在操作上，该合作伙伴关系结合了两个部门的优势和设施，致力于推进可用于治疗肌肉骨骼病变的新组织发生的知识。该研究项目的物理空间将18,000平方英尺的肌肉骨骼研究中心设备齐全的实验室与生物医学工程系新建的4层研究和办公楼（Goergen Hall）相结合。生物医学工程系和骨科系的综合优势为学术研究事业的发展提供了良好的环境。在指导、拨款写作、协作互动和科学技术方面的专业项目使该联盟成为启动和完成转化研究项目的丰硕基础。该申请将使用ARRA P30机制寻求资金，以支持生物医学工程和骨科部门的新招募（Danielle Benoit博士）。Benoit博士是一位具有杰出潜力的年轻科学家，已获得生物医学工程系（初级）和骨科（二级）的终身教职。她的研究兴趣包括开发用于肌肉骨骼再生医学的新型聚合物支架，以及利用微RNA技术控制复杂组织修复中的干细胞功能。这两个领域都符合肌肉骨骼研究中心和生物医学工程系的目标。

DESCRIPTION (provided by applicant): This proposal seeks to support a research program in the area of tissue engineering in the musculoskeletal sciences. It is aimed at enriching the infrastructure of a translational research partnership at the University of Rochester. The partnership is between the Department of Orthopaedics and the Department of Biomedical Engineering and bridges the School of Medicine and School of Engineering and Applied Sciences. Operationally, the partnership combines the strengths and facilities of two departments dedicated to advancing knowledge for the genesis of neotissues that may be used in the treatment of musculoskeletal pathologies. The physical space for this research program combines the 18,000 square foot fully equipped laboratory of the Center for Musculoskeletal Research with the newly constructed 4-story research and office building (Goergen Hall) for the Department of Biomedical Engineering. The combined strengths of the Departments of Biomedical Engineering and Orthopaedics provide an outstanding environment for the development of academic research careers. Specialized programs in mentoring, grant writing, collaborative interactions and scientific technologies make this alliance a fruitful ground for launching and completing translational research programs. This application will use the ARRA P30 mechanism to seek funds to support a new recruit (Dr. Danielle Benoit) to the Departments of Biomedical Engineering and Orthopaedics. Dr. Benoit is a young scientist with outstanding potential that has been offered a tenure track faculty appointment in the Department of Biomedical Engineering (primary) and Orthopaedics (secondary). Her areas of research interest are related to the development of novel polymer scaffolds for musculoskeletal regenerative medicine and the use of micro RNA technology to control stem cell function in the repair of complex tissues. Both areas fit well with the goals of the Center for Musculoskeletal Research and the Department of Biomedical Engineering.