Tissue Engineering and Therapeutic Advances in Musculoskeletal Medicine

描述(由申请人提供)：本提案旨在支持肌肉骨骼科学中组织工程领域的研究计划。它的目的是丰富罗切斯特大学翻译研究伙伴关系的基础设施。这一合作伙伴关系是骨科和生物医学工程系之间的合作伙伴关系，并在医学院和工程与应用科学学院之间架起桥梁。在业务上，这一伙伴关系结合了两个部门的力量和设施，这些部门致力于促进对可用于肌肉骨骼病理治疗的肿瘤组织起源的了解。该研究项目的物理空间结合了肌肉骨骼研究中心设备齐全的18,000平方英尺实验室和为生物医学工程系新建的4层研究和办公楼(格尔根大厅)。生物医学工程系和骨科系的综合优势为学术研究事业的发展提供了良好的环境。指导、拨款撰写、协作互动和科学技术方面的专门计划使该联盟成为启动和完成翻译研究计划的富有成效的场地。此应用程序将使用ARRA P30机制来寻求资金，以支持生物医学工程和整形外科的新招聘人员(Danielle Benoit博士)。Benoit博士是一位极具潜力的年轻科学家，已获得生物医学工程系(初级)和整形外科系(次级系)终身教职。她的研究领域涉及用于肌肉骨骼再生医学的新型聚合物支架的开发，以及使用微型RNA技术控制干细胞在复杂组织修复中的功能。这两个领域都非常符合肌肉骨骼研究中心和生物医学工程系的目标。

DESCRIPTION (provided by applicant): This proposal seeks to support a research program in the area of tissue engineering in the musculoskeletal sciences. It is aimed at enriching the infrastructure of a translational research partnership at the University of Rochester. The partnership is between the Department of Orthopaedics and the Department of Biomedical Engineering and bridges the School of Medicine and School of Engineering and Applied Sciences. Operationally, the partnership combines the strengths and facilities of two departments dedicated to advancing knowledge for the genesis of neotissues that may be used in the treatment of musculoskeletal pathologies. The physical space for this research program combines the 18,000 square foot fully equipped laboratory of the Center for Musculoskeletal Research with the newly constructed 4-story research and office building (Goergen Hall) for the Department of Biomedical Engineering. The combined strengths of the Departments of Biomedical Engineering and Orthopaedics provide an outstanding environment for the development of academic research careers. Specialized programs in mentoring, grant writing, collaborative interactions and scientific technologies make this alliance a fruitful ground for launching and completing translational research programs. This application will use the ARRA P30 mechanism to seek funds to support a new recruit (Dr. Danielle Benoit) to the Departments of Biomedical Engineering and Orthopaedics. Dr. Benoit is a young scientist with outstanding potential that has been offered a tenure track faculty appointment in the Department of Biomedical Engineering (primary) and Orthopaedics (secondary). Her areas of research interest are related to the development of novel polymer scaffolds for musculoskeletal regenerative medicine and the use of micro RNA technology to control stem cell function in the repair of complex tissues. Both areas fit well with the goals of the Center for Musculoskeletal Research and the Department of Biomedical Engineering.