The Female Reproductive Tract as a Portal of HIV Infection

女性生殖道是艾滋病毒感染的门户

• 批准号: 7684926
• 负责人: LINDA C GIUDICE
• 金额: $ 47.06万
• 依托单位: J. DAVID GLADSTONE INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7684926
• 关键词: Affect; Animal Model; Animals; Antiviral Agents; Atrophic; Binding; Biological Assay; Biological Models; Bradykinin; C 31G; CCR5 gene; CXCR4 gene; Capsid; Carrageenan; Categories; Cell Surface Receptors; Cell physiology; Cells; Cellular Immunity; Cervical; Clinical; Clinical Data; Clinical Trials; Coculture Techniques; Colitis; Collaborations; Contraceptive Agents; Country; Data; Decidual Cell Reactions; Depo Provera; Deposition; Detergents; Development; Electronics; Endocervix; Endometrial; Enhancers; Ensure; Epidemiologic Studies; Epithelial; Epithelial Cells; Epithelium; Exocervix; Exposure to; FDA approved; Failure; Female; Funding; Future; Galactosylceramides; Gene Expression; Goals; Growth; Guidelines; HIV; HIV Infections; HIV Receptors; Health; Heterosexuals; Histology; Homeostasis; Hormones; Human; Immune; Immune response; Immunology; In Vitro; Infection; Infiltration; Inflammation; Inflammatory; Information Distribution; Injury; Inorganic Sulfates; Institutes; Intrauterine Devices; Laboratories; Legal patent; Letters; Leukocytes; Mediating; Mediation; Methods; Modeling; Mucous Membrane; Nonoxynol 9; Paper; Pathway interactions; Phase III Clinical Trials; Policies; Polysaccharides; Pre-Clinical Model; Predisposition; Principal Investigator; Procedures; Production; Progestins; Protein Secretion; PubMed; Publications; Publishing; Reagent; Research; Research Personnel; Resistance; Resources; Risk; Safety; Sampling; San Francisco; Scientist; Seminal Plasma; Seminal fluid; Site; Spermatocidal Agents; Stratified Squamous Epithelium; Surface; Technical Expertise; Techniques; Testing; Time; Tissues; Translations; United States National Institutes of Health; United States National Library of Medicine; Unspecified or Sulfate Ion Sulfates; Ushercell; Vagina; Viral; Woman; Work; cellulose sulfate; condoms; cytokine; data sharing; dissemination research; genome wide association study; in vitro Assay; in vivo; inhibitor/antagonist; injured; interest; male; microbicide; novel; pandemic disease; preclinical safety; receptor; reproductive; response; safety testing; success; transmission process; trend; vaginal microbicide; virology

1 of WHP-San Francisco, serves as Director of the Gladstone Institute of Virology and Immunology. 16. LETTERS OF SUPPORT (e.g., Consultants) A letter from Dr. Mark Scott, who will provide technical expertise in regards to the handling of endocervical samples using the Luminex platform, is enclosed on page 133. 17. RESOURCE SHARING A major benefit of scientific research is its potential translation for the benefit of human health. Rapid sharing of scientific data and reagents/resources can potentially reduce the time between a discovery and the effective "translation" of that discovery. Scientific publications are the major mechanism for sharing data with other scientists and with the public at large. WHP-San Francisco investigators will make their published work available to interested scientists by submitting an electronic version of their paper to the National Library of Medicine's PubMed Central upon acceptance for publication. These papers will be made publicly available no later than 12 months after the official date of publication in accord with NIH Public Access Policy (NOT-OD-05-022). Similarly, reagents utilized in these publications will be made freely available to other academic investigators in a timely manner. The sharing of data and resources serves the best interest of overall scientific progress. When appropriate, patent protection may be sought for discoveries that may have commercial value. However, patenting procedures should not preclude the distribution of information or reagents to interested academic investigators, as outlined in the NIH Guidelines for Dissemination of Research Resources Arising Out of NIH-funded Research. WHP-San Francisco is dedicated to establishing the appropriate policies and procedures as a well as a culture for effective sharing of data and resources. Sharing Model Organisms: Development of model organisms is not planned in the current scope of work for WHP-San Francisco. Genome-Wide Association Studies (GWASj: Following publication of findings, microarray data generated in

WHP-旧金山的1人，担任Gladstone的董事 病毒学和免疫学研究所。 16.支持函(如顾问) 马克·斯科特博士的来信，他将提供有关宫颈内膜处理的技术专业知识 使用Luminex平台的样本附在第133页。 17.资源共享 科学研究的一个主要好处是其潜在的翻译对人类健康的好处。快速 共享科学数据和试剂/资源可以潜在地缩短发现和 这一发现的有效“翻译”。科学出版物是共享数据的主要机制 与其他科学家和广大公众进行交流。WHP-旧金山调查人员将使他们的 感兴趣的科学家可以通过将论文的电子版提交到 国家医学图书馆出版中心接受出版。这些文件将会是 根据美国国立卫生研究院的规定，在正式出版日期后12个月内公开可用 公共接入政策(非-OD-05-022)。同样，这些出版物中使用的试剂将 及时向其他学术研究人员免费提供。数据和资源的共享 服务于整体科学进步的最大利益。在适当的时候，可以寻求专利保护。 寻找可能具有商业价值的发现。然而，专利程序不应排除 将信息或试剂分发给感兴趣的学术研究人员，如美国国立卫生研究院所概述 由NIH资助的研究产生的研究资源的传播指南。WHP-SAN 弗朗西斯科致力于建立适当的政策和程序，以及一种 有效共享数据和资源。 共享模式生物：目前的工作范围不计划开发模式生物 为惠普-旧金山。 全基因组关联研究(GWASJ：发表研究结果后，微阵列数据 生成于