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The Female Reproductive Tract as a Portal of HIV Infection

The Female Reproductive Tract as a Portal of HIV Infection
女性生殖道是艾滋病毒感染的门户
批准号:
7684926
负责人:
LINDA C GIUDICE
金额:
$47.06万
依托单位国家:
美国
项目类别:
财政年份:
2009
资助国家:
美国
项目状态:
已结题
起止时间:
2009-09-01 至 2014-08-31
关键词:
AffectAnimal ModelAnimalsAntiviral AgentsAtrophicBindingBiological AssayBiological ModelsBradykininC 31GCCR5 geneCXCR4 geneCapsidCarrageenanCategoriesCell Surface ReceptorsCell physiologyCellsCellular ImmunityCervicalClinicalClinical DataClinical TrialsCoculture TechniquesColitisCollaborationsContraceptive AgentsCountryDataDecidual Cell ReactionsDepo ProveraDepositionDetergentsDevelopmentElectronicsEndocervixEndometrialEnhancersEnsureEpidemiologic StudiesEpithelialEpithelial CellsEpitheliumExocervixExposure toFDA approvedFailureFemaleFundingFutureGalactosylceramidesGene ExpressionGoalsGrowthGuidelinesHIVHIV InfectionsHIV ReceptorsHealthHeterosexualsHistologyHomeostasisHormonesHumanImmuneImmune responseImmunologyIn VitroInfectionInfiltrationInflammationInflammatoryInformation DistributionInjuryInorganic SulfatesInstitutesIntrauterine DevicesLaboratoriesLegal patentLettersLeukocytesMediatingMediationMethodsModelingMucous MembraneNonoxynol 9PaperPathway interactionsPhase III Clinical TrialsPoliciesPolysaccharidesPre-Clinical ModelPredispositionPrincipal InvestigatorProceduresProductionProgestinsProtein SecretionPubMedPublicationsPublishingReagentResearchResearch PersonnelResistanceResourcesRiskSafetySamplingSan FranciscoScientistSeminal PlasmaSeminal fluidSiteSpermatocidal AgentsStratified Squamous EpitheliumSurfaceTechnical ExpertiseTechniquesTestingTimeTissuesTranslationsUnited States National Institutes of HealthUnited States National Library of MedicineUnspecified or Sulfate Ion SulfatesUshercellVaginaViralWomanWorkcellulose sulfatecondomscytokinedata sharingdissemination researchgenome wide association studyin vitro Assayin vivoinhibitor/antagonistinjuredinterestmalemicrobicidenovelpandemic diseasepreclinical safetyreceptorreproductiveresponsesafety testingsuccesstransmission processtrendvaginal microbicidevirology

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1 of WHP-San Francisco, serves as Director of the Gladstone Institute of Virology and Immunology. 16. LETTERS OF SUPPORT (e.g., Consultants) A letter from Dr. Mark Scott, who will provide technical expertise in regards to the handling of endocervical samples using the Luminex platform, is enclosed on page 133. 17. RESOURCE SHARING A major benefit of scientific research is its potential translation for the benefit of human health. Rapid sharing of scientific data and reagents/resources can potentially reduce the time between a discovery and the effective "translation" of that discovery. Scientific publications are the major mechanism for sharing data with other scientists and with the public at large. WHP-San Francisco investigators will make their published work available to interested scientists by submitting an electronic version of their paper to the National Library of Medicine's PubMed Central upon acceptance for publication. These papers will be made publicly available no later than 12 months after the official date of publication in accord with NIH Public Access Policy (NOT-OD-05-022). Similarly, reagents utilized in these publications will be made freely available to other academic investigators in a timely manner. The sharing of data and resources serves the best interest of overall scientific progress. When appropriate, patent protection may be sought for discoveries that may have commercial value. However, patenting procedures should not preclude the distribution of information or reagents to interested academic investigators, as outlined in the NIH Guidelines for Dissemination of Research Resources Arising Out of NIH-funded Research. WHP-San Francisco is dedicated to establishing the appropriate policies and procedures as a well as a culture for effective sharing of data and resources. Sharing Model Organisms: Development of model organisms is not planned in the current scope of work for WHP-San Francisco. Genome-Wide Association Studies (GWASj: Following publication of findings, microarray data generated in
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Education - Outreach Core
UCSF Stanford Endometriosis Center for Discovery, Innovation, Training and Community Engagement
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