MOSAIC: Administrative Core

MOSAIC：行政核心

• 批准号: 10729421
• 负责人: Kristin R Swanson
• 金额: $ 20.86万
• 依托单位: MAYO CLINIC ARIZONA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729421
• 关键词: Administrator; Advisory Committees; Area; Authorization documentation; Award; Biopsy; Businesses; Collaborations; Communication; Communities; Core Biopsy; Data; Discipline; Educational workshop; Ensure; Evaluation; Faculty; Feedback; Funding; Glioma; Grant; Growth; Image; Institution; Institutional Review Boards; Leadership; Logistics; Machine Learning; Magnetic Resonance Imaging; Malignant Neoplasms; Mathematics; Monitor; Office of Administrative Management; Oncology; Pathology; Patients; Phenotype; Pilot Projects; Process; Publications; Radiology Specialty; Regulation; Reproducibility; Research Project Grants; Resource Sharing; Resources; Suggestion; Systems Analysis; Systems Biology; Tissues; Visit; Work; authority; career; clinical imaging; data access; data exchange; data integration; data management; data sharing; imaging facilities; interest; meetings; neuro-oncology; outreach; programs; recruit; symposium; training opportunity; web site

SUMMARY: ADMINISTRATIVE CORE The overarching objective for the Mayo/Columbia MOSAIC CSBC is to build a conceptual framework to understand tissue state transitions that happen in glioma and the ways to interpret magnetic resonance imaging (MRI) relative to those changes for these key cellular phenotypes. Achieving this objective will require a multi- faceted approach reflected by the multiple projects and cores being proposed. The administrative core will be the primary touchpoint for all pieces of the proposal, overseeing that work is done in an efficient way and providing the necessary administrative support to coordinate all efforts. The central work for our CSBC revolves around extensive analysis of image-localized biopsies that are collected, processed, and stored by Biospecimen Core, analyzed by the Data Integration and Computation Core, and shared between Projects 1 and 2. This highly integrated analysis of image-localized biopsies from GBM patients with clinical imaging will be actively managed by the Administrative Core to ensure a smooth experimental flow with an emphasis on quality and reproducibility. We envision that MOSAIC will serve as a nexus for collaborations focused on the topics revolving around tissue state transitions and clinical imaging across the consortium with likely areas of interest in other cancers beyond glioma. A key function of the Administrative Core will be to actively cultivate such collaborations through coordination with our Outreach Core, particularly through administering Intra-Center and Cross-Consortium Pilot Projects, hosting workshops and symposiums, and facilitating visiting faculty all while enhancing diverse perspectives on this critical topic. These activities will extend both to collaborations between institutions involved in the Mayo/Columbia CSBC and collaborations across the U54 and U01 holders within the CSBC and PSON networks. In the Administrative Core, our aims—to manage center logistics and communication, administer Intra-Center Pilot Projects, and create and support the External Advisory Committee—will support all aspects of our application. Co-PDs Swanson and Canoll will provide the central leadership in the Administrative Core, while the Center Program Administrator will provide day-to-day business, administrative and scientific management of Center activities.

摘要：管理核心 梅奥/哥伦比亚马赛克CSBC的总体目标是建立一个概念框架，以 了解胶质瘤中发生的组织状态转变以及解释磁共振成像的方法 (MRI)相对于这些关键细胞表型的变化。实现这一目标将需要多方面的- 所提出的多个项目和核心所反映的多面性方法。行政核心将是 提案所有部分的主要接触点，监督工作以高效的方式和 提供必要的行政支持，以协调所有努力。我们CSBC的中心工作围绕着 围绕由Biospecimen收集、处理和存储的图像定位活检的广泛分析 核心，由数据集成和计算核心分析，并在项目1和2之间共享。这 对GBM患者的影像定位活检与临床影像的高度集成分析将是积极的 由行政核心管理，以确保实验流程顺畅，强调质量和 再现性。 我们设想，马赛克将成为围绕组织主题的合作的纽带 该联盟的状态转换和临床成像，以及可能对其他癌症感兴趣的领域 神经胶质瘤。行政核心的一个关键职能将是通过以下方式积极培养这种合作 与我们的外联核心协调，特别是通过管理中心内和跨联盟试点 项目，举办研讨会和座谈会，为访问教员提供便利，同时增强多样性 对这一关键话题的看法。这些活动将扩展到相关机构之间的合作 在梅奥/哥伦比亚CSBC以及CSBC和PSON内U54和U01持有者之间的协作 网络。 在行政核心，我们的目标-管理中心的物流和通信，管理中心内部 试点项目，以及创建和支持外部咨询委员会--将支持我们的 申请。联合PDS Swanson和Canoll将提供行政核心的中央领导，而 中心项目管理员将提供日常业务、行政和科学管理 中心活动。