Administrative Core

摘要 - 行政核心 MIT/DFCI 胶质母细胞瘤系统生物学中心的总体框架是使用系统 生物学定义肿瘤-微环境界面的动态演化，重点关注发展 肿瘤细胞与神经元、肿瘤细胞与免疫细胞之间的共生关系，最终 使用这种系统级分子表征来定义新的治疗策略以消除 肿瘤进展并克服脑肿瘤的治疗耐药性。 While this CSBC Center is focused on 定义调节脑肿瘤进展、侵袭和免疫抑制的网络和途径， 这些问题与大多数实体瘤高度相关，包括一些最具侵袭性的肿瘤类型。因此， 我们预计该 CSBC 将成为专注于该主题的合作的纽带，也是关键职能之一 行政核心的重点将是积极培育这些合作。 These activities will extend both to 参与 MIT/DFCI CSBC 的机构之间的合作以及 U54 和 U01 之间的合作 holders within the CSBC network.该 CSBC 中心的核心工作围绕对以下方面的广泛分析： 由生物样本核心创建并在项目 1 和 2 之间共享的生物样本。 Core 提供生物样本和其他样本的超深入多组学表征，为两者提供数据 然后可以在每个项目内以及跨两个项目对项目进行建模。 This highly integrated analysis 生物样本的数量将由行政核心积极管理，以确保实验流程顺利进行。 最后，该核心将组织和管理中心咨询委员会、外部咨询委员会的活动。 board, and interactions with NCI staff.

ABSTRACT - ADMINISTRATIVE CORE The overarching framework for this MIT/DFCI Center for Systems Biology of Glioblastoma is to use systems biology to define the dynamic evolution of the tumor-microenvironment interface, focusing on the development of symbiotic relationships between tumor cells and neurons and tumor cells and immune cells, with the ultimate goal of using this systems-level molecular characterization to define novel therapeutic strategies to abrogate tumor progression and overcome therapeutic resistance in brain tumors. While this CSBC Center is focused on defining the networks and pathways regulating progression, invasion, and immunosuppression in brain tumors, these issues are highly relevant for most solid tumors, including some of the most aggressive tumor types. Thus, we envision this CSBC will serve as a nexus for collaborations focused on this topic, and one of the key functions of the Administrative Core will be to actively cultivate these collaborations. These activities will extend both to collaborations between institutions involved in the MIT/DFCI CSBC and collaborations across the U54 and U01 holders within the CSBC network. The central work for this CSBC Center revolves around extensive analysis of bio-specimens that are created by the Biospecimens Core and shared between Projects 1 and 2. The Analytical Core provides ultra-deep multi-‘omic characterization of biospecimens and other samples, providing data to both Projects that can then be modeled within each project and across both projects. This highly integrated analysis of biospecimens will be actively managed by the Administrative Core to ensure a smooth experimental flow. Finally, this Core will organize and manage the activities of the Center Advisory Committee, the external advisory board, and interactions with NCI staff.