Administrative Core

行政核心

• 批准号: 10729274
• 负责人: Forest M White
• 金额: $ 24.24万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729274
• 关键词: Administrator; Advisory Committees; Brain Neoplasms; Businesses; Cells; Collaborations; Communication; Data; Development; Education and Outreach; Ensure; Evaluation; Glioblastoma; Goals; Immune; Immunologics; Immunosuppression; Institution; Invaded; Leadership; Modeling; Molecular; Neurons; Office of Administrative Management; Pathway interactions; Program Evaluation; Progress Reports; Reproducibility; Research; Running; Sampling; Site Visit; Solid Neoplasm; Source; System; Systems Biology; Work; dynamical evolution; meetings; neoplastic cell; novel therapeutic intervention; process improvement; symposium; therapy resistant; tool; tumor; tumor microenvironment; tumor progression; web page

ABSTRACT - ADMINISTRATIVE CORE The overarching framework for this MIT/DFCI Center for Systems Biology of Glioblastoma is to use systems biology to define the dynamic evolution of the tumor-microenvironment interface, focusing on the development of symbiotic relationships between tumor cells and neurons and tumor cells and immune cells, with the ultimate goal of using this systems-level molecular characterization to define novel therapeutic strategies to abrogate tumor progression and overcome therapeutic resistance in brain tumors. While this CSBC Center is focused on defining the networks and pathways regulating progression, invasion, and immunosuppression in brain tumors, these issues are highly relevant for most solid tumors, including some of the most aggressive tumor types. Thus, we envision this CSBC will serve as a nexus for collaborations focused on this topic, and one of the key functions of the Administrative Core will be to actively cultivate these collaborations. These activities will extend both to collaborations between institutions involved in the MIT/DFCI CSBC and collaborations across the U54 and U01 holders within the CSBC network. The central work for this CSBC Center revolves around extensive analysis of bio-specimens that are created by the Biospecimens Core and shared between Projects 1 and 2. The Analytical Core provides ultra-deep multi-‘omic characterization of biospecimens and other samples, providing data to both Projects that can then be modeled within each project and across both projects. This highly integrated analysis of biospecimens will be actively managed by the Administrative Core to ensure a smooth experimental flow. Finally, this Core will organize and manage the activities of the Center Advisory Committee, the external advisory board, and interactions with NCI staff.

摘要 - 行政核心 这个MIT/DFCI系统生物学中心的总体框架是使用系统 生物学定义肿瘤微环境界面的动态演变，重点是发展 肿瘤细胞与神经元以及肿瘤细胞和免疫细胞之间的共生关系，最终 使用此系统级分子表征来定义新的治疗策略以消除 肿瘤进展并克服脑肿瘤的治疗性。虽然这个CSBC中心专注于 定义网络和途径调节脑肿瘤中的进展，侵袭和免疫抑制， 这些问题与大多数实体瘤高度相关，包括一些最具侵略性的肿瘤类型。那， 我们设想此CSBC将作为关注此主题的合作的联系，也是关键功能之一 行政核心将是积极培养这些合作。这些活动将扩展到 MIT/DFCI CSBC涉及的机构与U54和U01的合作之间的合作 CSBC网络中的持有人。该CSBC中心的中心工作围绕着对 由生物测量核心创建并在项目1和2之间共享的生物特异性。分析 Core提供了对生物测量和其他样品的超深度杂音表征，从而提供数据 然后可以在每个项目和两个项目中建模的项目。这个高度综合的分析 生物晶体的生物测量将由行政核心积极管理，以确保平稳的实验流。 最后，该核心将组织和管理中心咨询委员会的活动，外部咨询 董事会以及与NCI员工的互动。