Administrative Core

摘要-行政核心 麻省理工学院/DFCI胶质母细胞瘤系统生物学中心的总体框架是使用系统 生物学定义肿瘤微环境界面的动态演变，重点关注肿瘤微环境的发展。 肿瘤细胞与神经元、肿瘤细胞与免疫细胞之间的共生关系， 目的是利用这种系统水平的分子表征来定义新的治疗策略， 肿瘤进展和克服脑肿瘤中的治疗抗性。虽然CSBC中心专注于 定义调节脑肿瘤进展、侵袭和免疫抑制的网络和途径， 这些问题与大多数实体瘤（包括一些最具侵袭性的肿瘤类型）高度相关。因此，在本发明中， 我们设想，该中心将成为围绕这一主题开展合作的纽带，其主要职能之一是 行政核心的核心将是积极培养这些合作。这些活动将扩大到 参与麻省理工学院/DFCI CSBC的机构之间的合作以及U 54和U 01之间的合作 CSBC网络内的持有人。该中心的中心工作围绕着广泛的分析， 由生物标本核心创建并在项目1和项目2之间共享的生物标本。分析 核心提供生物标本和其他样品的超深多组学表征，为生物标本和其他样品提供数据。 然后可以在每个项目内以及跨两个项目建模的项目。这种高度综合的分析 管理中心将积极管理生物标本，以确保实验流程的顺利进行。 最后，该核心将组织和管理中心咨询委员会的活动，外部咨询委员会， 董事会，并与NCI工作人员的互动。

ABSTRACT - ADMINISTRATIVE CORE The overarching framework for this MIT/DFCI Center for Systems Biology of Glioblastoma is to use systems biology to define the dynamic evolution of the tumor-microenvironment interface, focusing on the development of symbiotic relationships between tumor cells and neurons and tumor cells and immune cells, with the ultimate goal of using this systems-level molecular characterization to define novel therapeutic strategies to abrogate tumor progression and overcome therapeutic resistance in brain tumors. While this CSBC Center is focused on defining the networks and pathways regulating progression, invasion, and immunosuppression in brain tumors, these issues are highly relevant for most solid tumors, including some of the most aggressive tumor types. Thus, we envision this CSBC will serve as a nexus for collaborations focused on this topic, and one of the key functions of the Administrative Core will be to actively cultivate these collaborations. These activities will extend both to collaborations between institutions involved in the MIT/DFCI CSBC and collaborations across the U54 and U01 holders within the CSBC network. The central work for this CSBC Center revolves around extensive analysis of bio-specimens that are created by the Biospecimens Core and shared between Projects 1 and 2. The Analytical Core provides ultra-deep multi-‘omic characterization of biospecimens and other samples, providing data to both Projects that can then be modeled within each project and across both projects. This highly integrated analysis of biospecimens will be actively managed by the Administrative Core to ensure a smooth experimental flow. Finally, this Core will organize and manage the activities of the Center Advisory Committee, the external advisory board, and interactions with NCI staff.