Administrative Core

行政核心

• 批准号: 10729274
• 负责人: Forest M White
• 金额: $ 24.24万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-15 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10729274
• 关键词: Administrator; Advisory Committees; Brain Neoplasms; Businesses; Cells; Collaborations; Communication; Data; Development; Education and Outreach; Ensure; Evaluation; Glioblastoma; Goals; Immune; Immunologics; Immunosuppression; Institution; Invaded; Leadership; Modeling; Molecular; Neurons; Office of Administrative Management; Pathway interactions; Program Evaluation; Progress Reports; Reproducibility; Research; Running; Sampling; Site Visit; Solid Neoplasm; Source; System; Systems Biology; Work; dynamical evolution; meetings; neoplastic cell; novel therapeutic intervention; process improvement; symposium; therapy resistant; tool; tumor; tumor microenvironment; tumor progression; web page

ABSTRACT - ADMINISTRATIVE CORE The overarching framework for this MIT/DFCI Center for Systems Biology of Glioblastoma is to use systems biology to define the dynamic evolution of the tumor-microenvironment interface, focusing on the development of symbiotic relationships between tumor cells and neurons and tumor cells and immune cells, with the ultimate goal of using this systems-level molecular characterization to define novel therapeutic strategies to abrogate tumor progression and overcome therapeutic resistance in brain tumors. While this CSBC Center is focused on defining the networks and pathways regulating progression, invasion, and immunosuppression in brain tumors, these issues are highly relevant for most solid tumors, including some of the most aggressive tumor types. Thus, we envision this CSBC will serve as a nexus for collaborations focused on this topic, and one of the key functions of the Administrative Core will be to actively cultivate these collaborations. These activities will extend both to collaborations between institutions involved in the MIT/DFCI CSBC and collaborations across the U54 and U01 holders within the CSBC network. The central work for this CSBC Center revolves around extensive analysis of bio-specimens that are created by the Biospecimens Core and shared between Projects 1 and 2. The Analytical Core provides ultra-deep multi-‘omic characterization of biospecimens and other samples, providing data to both Projects that can then be modeled within each project and across both projects. This highly integrated analysis of biospecimens will be actively managed by the Administrative Core to ensure a smooth experimental flow. Finally, this Core will organize and manage the activities of the Center Advisory Committee, the external advisory board, and interactions with NCI staff.

抽象行政核心 MIT/DFCI胶质母细胞瘤系统生物学中心的总体框架是使用系统 生物学定义了肿瘤-微环境界面的动态演变，侧重于发展 肿瘤细胞和神经元以及肿瘤细胞和免疫细胞之间的共生关系，最终 目标是利用这种系统水平的分子特征来定义新的治疗策略以消除 肿瘤的进展和克服脑肿瘤的治疗阻力。当这个CSBC中心专注于 确定调节脑瘤进展、侵袭和免疫抑制的网络和途径， 这些问题与大多数实体肿瘤高度相关，包括一些最具侵袭性的肿瘤类型。因此， 我们设想，CSBC将成为围绕这一主题的合作的纽带，也是主要职能之一 行政核心的核心将是积极培育这些合作。这些活动将扩展到 参与MIT/DFCI CSBC的机构之间的协作以及U54和U01之间的协作 CSBC网络内的持有者。CSBC中心的中心工作围绕着广泛的分析 由生物谱系核心创建并在项目1和项目2之间共享的生物标本。 CORE提供生物样品和其他样品的超深多组学表征，为两者提供数据 然后可以在每个项目内和跨两个项目进行建模的项目。这一高度集成的分析 管理核心将积极管理生物检疫剂的使用，以确保实验的顺利进行。 最后，该核心将组织和管理中心咨询委员会、外部咨询委员会的活动 董事会，以及与NCI工作人员的互动。