Administrative Core

行政核心

• 批准号: 9187648
• 负责人: Forest M White
• 金额: $ 27.77万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-29 至 2021-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9187648
• 关键词: Advisory Committees; Brain Neoplasms; Businesses; Cell Therapy; Clinic; Collaborations; Communication; Data; Development; Ensure; Evaluation; Financial Support; Fostering; Grant; Institutes; Life; Link; Logistics; NCI-Designated Cancer Center; Participant; Pharmaceutical Preparations; Pilot Projects; Research Infrastructure; Research Project Grants; Resistance; Resource Sharing; Resources; Site; Specimen; Training and Education; Tumor Tissue; anticancer research; base; drug distribution; drug efficacy; intercellular communication; meetings; member; neoplastic cell; outreach program; physical science

ADMINISTRATIVE CORE – PROJECT SUMMARY The overarching framework for this MIT/Mayo PS-OC is to understand the physical interactions between drugs, tumor tissue and the microenvironment that influence drug distribution and how potentially heterogeneous drug distribution influences tumor cell signaling and therapy resistance emergence (drug efficacy). The PS-OC will require a strong administrative unit to support and coordinate Center activities across all sites, projects and cores; including day-to-day administrative and financial support, planning and evaluation, ongoing communications, pilot and trans-network projects, CAC activities, participation in PS-ON Steering Committee and other initiatives developed over the life of the project. The MIT/Mayo PS-OC will be administratively based at MIT's Koch Institute of Integrative Cancer Research, an NCI-designated Cancer Center that was established in 1974. As demonstrated with past center grants based at the KI, this will allow us to leverage an existing, well-organized administrative infrastructure that will provide support for all business aspects related to the Center. Primary responsibility for scientific project management and managing the workflow of bio-specimens and related high-content data between the two Research Projects and two Shared Resource Cores will be based at the Mayo Clinic. Jointly the members of both teams will be referred to as the Administrative Unit (AU).

行政核心-项目摘要 麻省理工学院/马约PS-OC的总体框架是了解药物之间的物理相互作用， 肿瘤组织和影响药物分布的微环境，以及潜在的异质性药物 分布影响肿瘤细胞信号传导和治疗抗性出现（药物功效）。PS-OC将 需要一个强有力的行政单位来支持和协调中心在所有地点、项目和 核心资源;包括日常行政和财政支助、规划和评价，持续 通信、试点和跨网络项目、CAC活动、参与PS-ON指导委员会 以及在项目生命周期中制定的其他举措。麻省理工学院/马约PS-OC将在行政上基于 在麻省理工学院的科赫综合癌症研究所，一个由国家癌症研究所指定的癌症中心， 1974年正如过去在KI的中心赠款所证明的那样，这将使我们能够利用现有的， 组织良好的行政基础设施，将为与 中心主要负责科学项目管理和管理生物标本的工作流程 两个研究项目和两个共享资源核心之间的相关高内容数据将被 位于马约诊所。两个小组的成员将统称为行政股（Au）。