Idiographic Examination of Alcohol to Dampen Positive Emotions for Co-morbid Alcohol Use and PTSD

酒精的具体检查可抑制共病酒精使用和创伤后应激障碍的积极情绪

• 批准号: 10730599
• 负责人: Nicole Holland Weiss
• 金额: $ 43万
• 依托单位: UNIVERSITY OF RHODE ISLAND
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-17 至 2025-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730599
• 关键词: Address; Adverse reactions; Alcohol consumption; Alcohols; Area; Arousal; Communities; Computer software; Coupled; Cues; Data; Data Collection; Down-Regulation; Ecological momentary assessment; Emotional; Emotions; Environment; Event; Frequencies; Fright; General Practices; Health; Health Priorities; Healthcare; Heterogeneity; Hour; Individual; Intervention; Investigation; Life; Link; Modeling; Motivation; National Institute on Alcohol Abuse and Alcoholism; Negative Reinforcements; Outcome; Participant; Pattern; Personal Satisfaction; Persons; Physiological; Post-Traumatic Stress Disorders; Prevalence; Process; Public Health; Regulation; Reporting; Research; Research Personnel; Risk; Role; Sampling; Severities; Source; Statistical Methods; Stimulus Generalization; Symptoms; Time; Trauma; Typology; Work; alcohol comorbidity; alcohol risk; alcohol use disorder; behavior change; clinically significant; conditioning; early onset; experience; in vivo; innovation; inter-individual variation; positive emotional state; prevent; stem; trauma exposure

PROJECT SUMMARY/ABSTRACT Posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD) co-occur with high frequency (24- 61%). PTSD role have emotions suggest regulation) less via alcohol use. One explanation for these findings is This co-occurrence has considerable clinical significance. Individuals with co-occurring PTSD-AUD (vs. or AUD alone) report more PTSD symptoms and worse alcohol outcomes. Research emphasizes the of emotional processes in the co-occurrence of PTSD and AUD. However, prior investigations in this area been narrow in scope, focusing almost exclusively on negative emotions. The limited research on positive purports a role of alcohol use in up-regulating (eliciting/increasing) positive emotions. Our pilot data that alcohol use among individuals with PTSD symptoms also may be motivated by avoidance (down- of positive emotions . We have found that trauma-exposed individuals with PTSD symptoms are accepting of positive emotions, and more likely to engage in fforts to avoid positive emotions, including that positive emotions elicit physiological e arousal that is linked to trauma-related symptoms and thus evaluated as aversive among individuals with PTSD symptoms. The processes current proposal will leverage intensive l ongitudinal data t o evaluate dynamic and idiographic among positive emotional processes, alcohol use, and PTSD symptoms as they unfold in daily life among trauma-exposed community individuals who regularly drink and experience PTSD symptoms (N=150). Ecological momentary assessment (EMA) will capture momentary processes in real-time & in natural settings, maximizing profiles. ecological validity and generalizability of findings. Idiographic analysis will identify personalized risk These approacheswill provide the necessary data to inform idiographic PTSD-AUD interventions that can be implemented at the microlevel. Aim 1 determines the extent to which PTSD symptoms are related to alcohol use to down-regulate positive emotions at the momentary level. Aim 2 usesidiographic analysis to identifypatterns of alcohol to down-regulate positive emotions in relation to PTSD. An Exploratory Aim assesses whether alcohol use to down-regulate positive emotions is distinct from other motives for alcohol use. The findings of this research have the potential to transform health care practice. General practice is to increase positive emotions in PTSD-AUD intervention. If our pilot work is confirmed, and alcohol use serves to down-regulate positive emotions in those with PTSD symptoms, clinicians may first want to evaluate adverse reactions to positive emotions in PTSD-AUD intervention, and, if indicated, address those concerns. The proposed research utilizes an innovative approach to fill significant gaps regarding mechanisms in co- occurring PTSD-AUD. This work is important, timely, and innovative. Preventing PTSD-AUD among trauma- exposed individuals has important implications for the health and well-being of people in our nation.

项目总结/摘要 创伤后应激障碍（PTSD）和酒精使用障碍（AUD）同时发生的频率很高（24- 30岁）。 61%）。 PTSD 作用 有 情绪 建议 （条例） 少 通过酒精的使用。对这些发现的一种解释是 这种并发症具有相当大的临床意义。合并PTSD-AUD的个体（vs. 或单独使用AUD）报告更多的PTSD症状和更差的酒精结果。研究强调， 创伤后应激障碍和澳元兑美元的共同发生的情绪过程。然而，这一领域的先前调查 范围狭窄，几乎只关注负面情绪。积极的有限研究 声称酒精使用在上调（引发/增加）积极情绪中的作用。我们的试点数据 有创伤后应激障碍症状的人饮酒也可能是出于回避（下）， 积极的情绪。我们发现，有创伤后应激障碍症状的创伤暴露者， 接受积极的情绪，更有可能陷入困境，以避免积极的情绪，包括 积极的情绪会引发生理上的 e 觉醒， 与创伤相关的症状有关，因此在有PTSD症状的个体中被评估为令人厌恶。 的 过程 目前的建议将利用密集的长期数据来评估动态和具体的 积极的情绪过程，酒精使用和PTSD症状，因为它们在日常生活中展开， 在经常饮酒并经历PTSD症状的创伤暴露社区个体中（N=150）。 生态瞬时评估（EMA）将实时捕捉自然环境中的瞬时过程， 最大 数据区. 研究结果的生态有效性和普遍性。具体分析将识别个性化风险 这些方法将提供必要的数据，以告知具体的PTSD-AUD干预措施， 可以在微观层面上实现。目的1确定PTSD症状与以下因素相关的程度： 酒精的使用，以下调积极的情绪在瞬间的水平。目的2利用地理分析， 确定酒精的种类，以下调与PTSD有关的积极情绪。探索性目标 评估是否使用酒精来下调积极情绪是不同于其他动机的酒精使用。 这项研究的结果有可能改变医疗保健实践。一般做法是 增加PTSD-AUD干预中的积极情绪。如果我们的试点工作得到证实，酒精的使用有助于 下调PTSD症状患者的积极情绪，临床医生可能首先要评估不良情绪， PTSD-AUD干预中对积极情绪的反应，如果有必要，解决这些问题。 拟议的研究采用了一种创新的方法，以填补有关共同机制的重大空白， 发生PTSD-AUD。这项工作是重要的，及时的和创新的。在创伤中预防PTSD-AUD 暴露的个人对我国人民的健康和福祉具有重要影响。