Native Alzheimer Disease Resource Center for Minority Aging Research (NAD-RCMAR)

总体摘要 美国印第安人/阿拉斯加原住民(AI/ANS)和夏威夷原住民和太平洋岛民(NHPI)越来越多 关注阿尔茨海默病和相关痴呆症(ADRD)，因为这些情况很快就会有一个重大的 对他们的社区产生影响。虽然人工智能/ANS和NHPI在文化上是多样化的，但它们都有很高的患病率 ADRD风险因素。AI/AN和NHPI的预期寿命已提高，导致其 65岁及以上人口所占比例。这些不断变化的人口结构使ADRD变得更加明显 在AI/AN和NHPI社区。AI/AN和NHPI还面临着与他们的身体、精神、 生命过程中的精神和情感健康会增加他们在健康结果方面的差异，减少 他们在中老年的复原力，并增加了他们患ADRD的脆弱性和风险。……的汇合 感知的需求、高风险和有限的数据是本机续订申请的基础 少数民族老龄化研究阿尔茨海默病资源中心(NAD-RCMAR)。我们的跨学科 研究团队提供独特的科学资源，并整合了来自多个学科和 广泛的社区伙伴关系网络。在迈阿密大学和华盛顿州 大学、北亚利桑那大学、新墨西哥大学、维克森林大学和 由土著研究人员领导的卫星中心覆盖了7个卫生和公共服务地区和夏威夷，我们 将继续创建和发展一项创新计划，以了解、干预和缓解ADRD- AI/ANS和NHPI经历的相关健康差距。我们的首要目标是资助功勋飞行员 由被称为NAD-RCMAR科学家的早期调查人员领导的研究，他们的工作将推动我们的 了解人工智能/AN和NHPI社区的ADRD健康差距；为NAD-RCMAR科学家提供 在研究设计、文化上适当的研究方法、生物统计学方法方面的指导，以便他们的 工作符合最高科学标准；提供职业发展活动以加强NAD-RCMAR 科学家在ADRD研究中的学术进步和对独立职业的追求； 关于其他少数群体中的ADRD的经验证据。我们的具体目标是1)建立一个充满活力的 基础设施，并提供科学专门知识和资源，以加强ADRD研究的多样性 劳动力；2)招聘和指导有前途的NAD-RCMAR科学家，特别是AI/AN、NHPI和其他领域的科学家 URM背景，在社会、行为、流行病学和临床科学方面进行初步研究 ADRD；以及3)促进ADRD研究的进展，增加独立的AI/AN、NHPI和 其他URM研究人员，他们可以解决AI/AN和NHPI长辈的健康和福祉问题。领导层， 我们团队的资源和经验为解决NIA的研究重点提供了前所未有的机会 针对2019年NIA BSR报告中阐述的主题的URM中的ADRD。我们的中心直接回应 NIA对使科学工作者多样化的兴趣。

OVERALL ABSTRACT American Indians/Alaska Natives (AI/ANs) and Native Hawaiians and Pacific Islanders (NHPIs) are increasingly concerned about Alzheimer’s disease and related dementias (ADRD), as these conditions will soon have a major impact on their communities. Although AI/ANs and NHPIs are culturally diverse, they share a high prevalence of ADRD risk factors. Life expectancies for AI/ANs and NHPIs have improved resulting in a tripling of their population share of people aged 65 and older. These changing demographics make ADRD much more visible in AI/AN and NHPI communities. AI/ANs and NHPIs also face challenges related to their physical, mental, spiritual, and emotional health over the life course that increases their disparities in health outcomes, reduces their resiliency in mid- and late-life, and increases their vulnerability and risk of ADRD. The confluence of perceived need, high risk, and limited data serves as the basis for the renewal application of the Native Alzheimer’s Disease Resource Center in Minority Aging Research (NAD-RCMAR). Our transdisciplinary research team offers unique scientific resources and integrates perspectives from multiple disciplines and an extensive network of community partnerships. Based at the University of Miami along with Washington State University, Northern Arizona University, University of New Mexico, Wake Forest University, and a network of Satellite Centers led by Indigenous researchers covering 7 Health and Human Services regions and Hawaii, we will continue to create and grow an innovative program to understand, intervene on, and mitigate the ADRD- related health disparities experienced by AI/ANs and NHPIs. Our overarching goals are to fund meritorious Pilot Studies led by early-stage investigators known as NAD-RCMAR Scientists, whose work will advance our understanding of ADRD health disparities in AI/AN and NHPI communities; provide NAD-RCMAR Scientists with mentorship in study design, culturally appropriate research methodology, biostatistical approaches so that their work meets the highest scientific standards; deliver career development activities to enhance NAD-RCMAR Scientists' academic advancement and the pursuit of independent careers in ADRD research; and contribute empirical evidence regarding ADRD in other minority populations. Our Specific Aims are to 1) Build a dynamic infrastructure, and provide scientific expertise and resources to enhance the diversity of the ADRD research workforce; 2) Recruit and mentor promising NAD-RCMAR Scientists, especially those of AI/AN, NHPI, and other URM backgrounds, to conduct Pilot Studies in the social, behavioral, epidemiological, and clinical sciences on ADRD; and 3) Promote advances in ADRD research and increase the number of independent AI/AN, NHPI and other URM researchers who can address the health and well-being of AI/AN and NHPI elders. The leadership, resources, and experience of our team offer an unprecedented opportunity to address NIA’s research priorities for ADRD among URMs with themes articulated in the 2019 NIA BSR Report. Our Center directly responds to NIA’s interest in diversifying the scientific workforce.