CLINICAL CORE (AND SMP)

临床核心是ADC研究主题的中心来源。其主要功能是提供ADC相关的研究项目和试点研究，以及诊断良好的受试者和临床材料（例如，血液、CSF等）。临床核心包括一个卫星多元文化计划（SMP），重点是少数民族的招聘。核心人群目前包括超过4，900例病例，包括AD、其他痴呆和轻度认知障碍患者以及正常成人受试者。核心课程每年新增约150至200个科目。对人口进行纵向重新评估 并追踪到尸检现场所有数据都包含在由数据管理核心维护的中央数据库中。 在过去的五年里，临床核心已经超过实现其具体目标。从2005年1月1日至2009年3月20日，完成了732例新患者和1，797例随访评价。自2005年10月以来，国家阿尔茨海默氏症协调中心（NACC）统一数据集（UDS）的措施已完成临床核心受试者，导致任何ADC的最大UDS人群，包括1,167名受试者，其中708次随访。大多数核心受试者参与各种研究方案。自2005年以来，超过38个单独的联邦资助的研究赠款已利用临床核心资源。该中心帮助支持一个临床试验单位，该单位参加了多中心的NIA-Alzheimer病合作研究（ADCS），自2005年以来，该中心参加了26项NIH ADCS和行业赞助的药理学试验。核心还维护CSF库和血清/DNA库，并与所有其他ADC核心密切相互作用。随着更新，我们建议继续将临床核心集中在正常认知和轻度认知障碍之间的过渡上。我们会继续跟进 登记的患者。这样的努力将支持我们目前的NIH赠款组合，NIH NACC UDS受试者贡献，ADCS研究和药物试验，以及其他合作和研究，并使我们能够针对治疗预防试验。

The Clinical Core serves as the central source of research subjects for the ADC. Its primary function is to provide ADC associated research projects and pilot studies with well-diagnosed subjects and with clinical materials (e.g., blood, CSF, etc.). The Clinical Core includes a Satellite Multicultural Program (SMP), which focuses on minority recruitment. The Core population currently includes more than 4,900 cases consisting of patients with AD, other dementias, and mild cognitive impairment, as well as normal adult subjects. About 150 to 200 new subjects have been added to the Core annually. The population is reassessed longitudinally and tracked to autopsy. All data are included in a central database maintained by the Data Management Core. During the past five years the Clinical Core has more than achieved its specific aims. From 1/1/2005 to 3/20/2009, 732 new patients and 1,797 follow-up evaluations were completed. Since October, 2005, National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) measures have been completed in Clinical Core subjects resulting in the largest UDS population of any ADC, comprising 1,167 subjects on whom 708 follow-ups have been conducted. Most Core subjects participate in various research protocols. Since 2005, more than 38 separate federally funded research grants have utilized Clinical Core resources. The Core helps support a Clinical Trials Unit which participates in the multicenter NIA-Alzheimer's Disease Cooperative Study (ADCS) and since 2005, the Core has participated in 26 NIH ADCS and industry sponsored pharmacologic trials. The Core also maintains a CSF bank and a serum/DNA bank and has close interactions with all of the other ADC Cores. With renewal, we propose to continue to focus the Clinical Core on the transition between normal cognition and mild cognitive impairments. We will continue to follow-up enrolled patients. Such an effort will support our current portfolio of NIH grants, NIH NACC UDS subject contributions, ADCS studies and medication trials, as well as other collaborations and studies, and enable us to target therapeutic prevention trials.