CLINICAL CORE (AND SMP)

临床核心（和 SMP）

• 批准号: 8672570
• 负责人: James E Galvin
• 金额: $ 54.67万
• 依托单位: NEW YORK UNIVERSITY SCHOOL OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-05-01 至 2015-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8672570
• 关键词: Address; Adult; African American; Alzheimer' s Disease; American; Area; Autopsy; Behavioral Symptoms; Biological Markers; Blood; Blood specimen; Brain; Caribbean region; Categories; Clinical; Clinical Research; Clinical Trials; Clinical Trials Unit; Clinical assessments; Cognition; Collaborations; DNA; DNA Library; Data; Data Set; Databases; Dementia; Development; Diagnosis; Diagnostic; Early Diagnosis; Elderly; Enrollment; Ethnic Origin; Evaluation; Exclusion Criteria; FDA approved; Family Study; Funding; Future; Goals; Grant; Impaired cognition; Industry; Measures; Methods; Minority; Participant; Patients; Pharmaceutical Preparations; Pilot Projects; Population; Postdoctoral Fellow; Prevention; Prevention Research; Protocols documentation; Psychosocial Assessment and Care; Race; Recruitment Activity; Research; Research Personnel; Research Project Grants; Research Subjects; Research Support; Resources; Scientist; Serum; Severities; Socioeconomic Factors; Source; Staging; Underserved Population; United States National Institutes of Health; Work; aging brain; biobank; clinical material; cooperative study; data management; follow-up; improved; inclusion criteria; interest; mild cognitive impairment; minority subjects; motor impairment; neuroimaging; neuropathology; older patient; programs; psychosocial; research study; success; therapeutic target; tool

The Clinical Core serves as the central source of research subjects for the ADC. Its primary function is to provide ADC associated research projects and pilot studies with well-diagnosed subjects and with clinical materials (e.g., blood, CSF, etc.). The Clinical Core includes a Satellite Multicultural Program (SMP), which focuses on minority recruitment. The Core population currently includes more than 4,900 cases consisting of patients with AD, other dementias, and mild cognitive impairment, as well as normal adult subjects. About 150 to 200 new subjects have been added to the Core annually. The population is reassessed longitudinally and tracked to autopsy. All data are included in a central database maintained by the Data Management Core. During the past five years the Clinical Core has more than achieved its specific aims. From 1/1/2005 to 3/20/2009, 732 new patients and 1,797 follow-up evaluations were completed. Since October, 2005, National Alzheimer's Coordinating Center (NACC) Uniform Data Set (UDS) measures have been completed in Clinical Core subjects resulting in the largest UDS population of any ADC, comprising 1,167 subjects on whom 708 follow-ups have been conducted. Most Core subjects participate in various research protocols. Since 2005, more than 38 separate federally funded research grants have utilized Clinical Core resources. The Core helps support a Clinical Trials Unit which participates in the multicenter NIA-Alzheimer's Disease Cooperative Study (ADCS) and since 2005, the Core has participated in 26 NIH ADCS and industry sponsored pharmacologic trials. The Core also maintains a CSF bank and a serum/DNA bank and has close interactions with all of the other ADC Cores. With renewal, we propose to continue to focus the Clinical Core on the transition between normal cognition and mild cognitive impairments. We will continue to follow-up enrolled patients. Such an effort will support our current portfolio of NIH grants, NIH NACC UDS subject contributions, ADCS studies and medication trials, as well as other collaborations and studies, and enable us to target therapeutic prevention trials.

临床核心是ADC研究对象的核心来源。它的主要功能是为ADC相关的研究项目和试点研究提供诊断良好的受试者以及临床材料（例如，血液，CSF等）。临床核心包括卫星多元文化计划（SMP），该计划的重点是少数族裔招募。目前的核心人群包括4,900多例病例，包括AD，其他痴呆症和轻度认知障碍以及正常成人受试者。每年已将约150至200个新主题添加到核心。人口纵向重新评估 并追踪到尸检。所有数据都包含在数据管理核心维护的中央数据库中。 在过去的五年中，临床核心超出了其具体目标。从2005年1月1日到2009年3月20日，完成了732名新患者和1,797例随访评估。自2005年10月以来，国家阿尔茨海默氏症协调中心（NACC）统一数据集（UDS）措施已在临床核心受试者中完成，导致任何ADC中最大的UDS人群，其中1,167名受试者已进行了708个随访。大多数核心主题都参与了各种研究方案。自2005年以来，有38多个联邦资助的研究补助金已经利用了临床核心资源。核心帮助支持一个临床试验单元，该单元参加了多中心Nia-Alzheimer疾病合作研究（ADCS），自2005年以来，核心已参加了26个NIH ADC和行业赞助的药理试验。该核心还维护了CSF银行和血清/DNA库，并与所有其他ADC核心进行了密切的互动。随着续约，我们建议继续将临床核心集中在正常认知和轻度认知障碍之间的过渡上。我们将继续跟进 注册患者。这样的努力将支持我们当前的NIH赠款，NIH NACC UDS主题贡献，ADCS研究和药物试验以及其他合作和研究，并使我们能够针对预防治疗性预防试验。