UCSF Older Americans Independence Center

项目摘要-加州大学旧金山分校老年美国人独立中心(OAIC) 加州大学旧金山分校OAIC的主题是“老年残疾的预测因素、结果和改善：关注 老年残疾将影响80%的老年美国人，对 患者和照顾者的生活质量，并承担着巨大的成本。这些挑战对老年人有特别的共鸣 易受伤害的成年人，我们将其概念化为医疗脆弱性(如 如患有复杂多发病的人患上癌症)和社会脆弱性(如社会孤立或贫困)。 我们致力于推进预防和改善老年人残疾的科学 这些脆弱性在很大程度上是通过指导和支持老龄化科学的未来领导者来实现的 发展这一主题。在我们的头9年里，加州大学旧金山分校的OAIC支持和指导了一个跨学科的 研究人员社区，他们的范式转换研究改变了临床实践和政策， 在我们对残疾的理解方面取得了重大进展，包括阐明了 医疗和社会脆弱性。我们一直是加州大学旧金山分校的一股激励力量，将老龄化科学注入到 专业和学科种类繁多。我们致力于培养下一代研究人员 导致在影响最大的期刊上发表文章，R01奖，空前数量的GEMSSTAR和 比森奖和OAIC领导人导师奖。 在下一个周期中，我们将在我们的成功记录的基础上，同时在新的 应对新兴机遇的方向。我们的两个资源核心-数据和分析核心(DAC) 和脆弱老龄化研究核心(VARC)-将催化广泛的临床和结果 研究。我们的研究和教育部分(REC)学者以及试点和探索性研究(PESC) 将为学者提供资源、指导和社区，以建立长期研究的平台 在我们的主题领域取得成功。我们的领导和行政核心(LAC)将指导中心的活动 并确保我们所有核心和活动之间的紧密结合。共同努力，我们将推进我们的 中心的5个目标：(1)通过充当以下中心，促进对弱势老年人残疾的研究 将学者聚集在一起，利用资源推动老龄残疾科学和职业发展； (2)提供对数据资源的核心访问、统计支持以及招收和留住弱势群体的专业知识 更年长的研究对象，以刺激对残疾的新研究；(3)确定老年医学的未来领导者 通过职业发展资助和特殊指导，研究和促进他们的发展；(4) 支持加速衰老科学的先导研究，并为晚年残疾研究提供资金；以及(5) 建立一个促进跨学科合作的领导和管理结构，使OAIC 大于其各部分之和。

PROJECT SUMMARY ABSTRACT – Overall UCSF Older Americans Independence Center (OAIC) The UCSF OAIC theme is "Predictors, Outcomes, and Amelioration of Late-life Disability: A Focus on Vulnerable Populations." Late-life disability will affect 80% of older Americans, has a profound impact on patient and caregiver quality of life, and carries large costs. These challenges have special resonance for older adults who are vulnerable, which we conceptualize as a complex interplay of both medical vulnerability (such as cancer in persons with complex multimorbidity) and social vulnerability (such as social isolation or poverty). We are deeply committed to advancing the science of preventing and ameliorating disability in older adults with these vulnerabilities, in large part by mentoring and supporting the future leaders of aging science who will develop this theme. During our first 9 years, the UCSF OAIC has supported and mentored an interdisciplinary community of investigators whose paradigm-shifting research that has changed clinical practice and policy and yielded major advances in our understanding of disability, including elucidating inextricable linkages between medical and social vulnerabilities. We have been a galvanizing force at UCSF, infusing aging science into a wide array of specialties and disciplines. Our dedication to developing the next generation of researchers has led to publications in the highest impact journals, R01 awards, an unprecedented number of GEMSSTAR and Beeson Awards, and mentorship awards for OAIC Leaders. During the next cycle, we will build on our track record of success while growing and innovating in new directions to respond to emerging opportunities. Our two resource cores – the Data and Analysis Core (DAC) and the Vulnerable Aging Research Core (VARC) - will catalyze a wide spectrum of clinical and outcomes research. Our Research and Education Component (REC) Scholars and Pilot and Exploratory Studies (PESC) Scholars will be provided the resources, mentorship, and community to build a platform for long-term research success in our theme area. Our Leadership and Administration Core (LAC) will guide the Center's activities and mission and ensure tight integration between all of our Cores and activities. Together, we will advance our center's 5 aims: to (1) Catalyze research on disability in vulnerable older persons by serving as a hub that brings together scholars and leverages resources to advance aging disability science and career development; (2) Provide core access to data resources, statistical support, and expertise enrolling and retaining vulnerable older subjects in order to stimulate new research on disability; (3) Identify the future leaders of geriatrics research and catalyze their development with career development funding and exceptional mentoring; (4) Support pilot studies that accelerate aging science and lead to research funding in late life disability; and (5) Develop a leadership and administrative structure that spurs interdisciplinary collaboration, making the OAIC greater than the sum of its parts.