UCSF Older Americans Independence Center

项目概要摘要-整体UCSF老年美国人独立中心（OAIC） UCSF OAIC的主题是“预测，结果和改善晚年残疾：重点是 弱势群体。"晚年残疾将影响80%的美国老年人，对 患者和护理人员的生活质量，并带来巨大的成本。这些挑战对老年人有特别的影响。 脆弱的成年人，我们将其概念化为医疗脆弱性（如 复杂多发性硬化症患者的癌症）和社会脆弱性（如社会孤立或贫困）。 我们坚定地致力于推进预防和改善老年人残疾的科学， 这些脆弱性，在很大程度上是通过指导和支持未来的老龄化科学领导者，他们将 发展这个主题。在我们的头9年，UCSF OAIC支持和指导了一个跨学科的 研究者社区，他们的范式转变研究改变了临床实践和政策， 在我们对残疾问题的理解方面取得了重大进展，包括阐明了 医疗和社会脆弱性。我们一直是UCSF的一股激励力量，将衰老科学注入到一个 广泛的专业和学科。我们致力于培养下一代研究人员， 在最具影响力的期刊上发表文章，R01奖，前所未有的GEMSSTAR数量， Beeson奖和OAIC领导人导师奖。 在下一个周期，我们将在成功的基础上，在新的领域发展和创新， 以应对新出现的机遇。我们的两个资源核心-数据和分析核心（DAC） 和脆弱老龄化研究核心（VARC）-将促进广泛的临床和结果 research.我们的研究和教育部分（REC）学者和试点和探索性研究（PESC） 将为学者提供资源、指导和社区，以建立长期研究平台 在主题领域取得成功。我们的领导和行政核心（LAC）将指导中心的活动 和使命，并确保我们所有的核心和活动之间的紧密集成。我们将共同推进我们的 该中心的5个目标是：（1）作为一个中心， 汇集学者和利用资源，以推进老龄残疾科学和职业发展; (2)提供对数据资源的核心访问、统计支持以及招募和留住弱势群体的专业知识 老年学科，以刺激新的研究残疾;（3）确定未来的领导人，老年医学 研究并通过职业发展资助和特殊辅导促进他们的发展;（4） 支持试点研究，加速老龄化科学，并导致晚年残疾的研究资金;和（5） 发展一个促进跨学科合作的领导和行政结构，使OAIC 大于各部分的总和。

PROJECT SUMMARY ABSTRACT – Overall UCSF Older Americans Independence Center (OAIC) The UCSF OAIC theme is "Predictors, Outcomes, and Amelioration of Late-life Disability: A Focus on Vulnerable Populations." Late-life disability will affect 80% of older Americans, has a profound impact on patient and caregiver quality of life, and carries large costs. These challenges have special resonance for older adults who are vulnerable, which we conceptualize as a complex interplay of both medical vulnerability (such as cancer in persons with complex multimorbidity) and social vulnerability (such as social isolation or poverty). We are deeply committed to advancing the science of preventing and ameliorating disability in older adults with these vulnerabilities, in large part by mentoring and supporting the future leaders of aging science who will develop this theme. During our first 9 years, the UCSF OAIC has supported and mentored an interdisciplinary community of investigators whose paradigm-shifting research that has changed clinical practice and policy and yielded major advances in our understanding of disability, including elucidating inextricable linkages between medical and social vulnerabilities. We have been a galvanizing force at UCSF, infusing aging science into a wide array of specialties and disciplines. Our dedication to developing the next generation of researchers has led to publications in the highest impact journals, R01 awards, an unprecedented number of GEMSSTAR and Beeson Awards, and mentorship awards for OAIC Leaders. During the next cycle, we will build on our track record of success while growing and innovating in new directions to respond to emerging opportunities. Our two resource cores – the Data and Analysis Core (DAC) and the Vulnerable Aging Research Core (VARC) - will catalyze a wide spectrum of clinical and outcomes research. Our Research and Education Component (REC) Scholars and Pilot and Exploratory Studies (PESC) Scholars will be provided the resources, mentorship, and community to build a platform for long-term research success in our theme area. Our Leadership and Administration Core (LAC) will guide the Center's activities and mission and ensure tight integration between all of our Cores and activities. Together, we will advance our center's 5 aims: to (1) Catalyze research on disability in vulnerable older persons by serving as a hub that brings together scholars and leverages resources to advance aging disability science and career development; (2) Provide core access to data resources, statistical support, and expertise enrolling and retaining vulnerable older subjects in order to stimulate new research on disability; (3) Identify the future leaders of geriatrics research and catalyze their development with career development funding and exceptional mentoring; (4) Support pilot studies that accelerate aging science and lead to research funding in late life disability; and (5) Develop a leadership and administrative structure that spurs interdisciplinary collaboration, making the OAIC greater than the sum of its parts.