CORE-001 - OPERATIONS CORE

CORE-001 - 运营核心

• 批准号: 10728896
• 负责人: Lauren Ferrante
• 金额: $ 30.02万
• 依托单位: YALE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10728896
• 关键词: Aging; American; Award; Biometry; Biostatistics Core; Budgets; Capsicum; Caring; Clinical Informatics; Collaborations; Communities; Computer software; Consultations; Data; Data Collection; Data Mart; Data Reporting; Development; Education; Elderly; Ensure; Equipment; Extramural Activities; Fostering; Funding; Funding Agency; Future; Goals; Grant; Health system; Informatics; Infrastructure; Institution; Investigation; Mentors; Methodology; Mission; Monitor; Peer Review; Policies; Population; Publications; Reporting; Research; Research Personnel; Research Project Grants; Research Support; Resources; Services; Silver; Software Design; Software Tools; System; Training; United States National Institutes of Health; Veterans Health Administration; Work; data management; data sharing; database design; design; electronic data; electronic data capture system; improved; informatics infrastructure; innovation; next generation; novel; operation; participant safety; programs; recruit; skills; software development; technological innovation; tool

The Operations Core (OC) supports research on multifactorial geriatric conditions by recruiting older adults who are diverse and representative, engaging older adults from the community as stakeholders, monitoring the safety of participants, offering resources to support aging research, designing electronic data collection sys- tems that result in high-quality data, developing software applications to support study workflow and analysis, and collecting, preparing and reporting data that account for the complexity of multifactorial aging research. The overall goal of the OC (RC1) is to ensure the successful implementation of multifactorial aging research. This goal will be accomplished by leading coordinated efforts with OAIC investigators and research staff. The Specific Aims of the OC are to: (1) provide services to achieve the aims of OAIC-funded and other aging-fo- cused research projects and the infrastructure to support investigators leading these projects; (2) collaborate to improve field, data management and informatics methodologies needed to advance aging-focused research on multifactorial geriatric conditions and to foster the development of the next generation of aging-focused investi- gators; and (3) conduct innovative Development Projects that advance the mission of the Yale OAIC. During the current funding cycle (2018-present), the OC provided research support for 16 OAIC-funded projects and 35 External Projects, consulted with 116 Yale investigators on field and data management plans for projects and grant submissions, was awarded NIH supplemental funding to build an innovative suite of soft- ware tools called the Yale Study Support Suite, and collaborated with other Pepper Centers and NIA-spon- sored programs on research projects, delivery of educational seminars, and software dissemination. These OC efforts have resulted in 129 publications and more than 30 extramurally funded grants totaling over $150 mil- lion. During the next funding cycle, the OC will: (1) collaborate on 5 of the 6 proposed REC and PESC projects and 34 of the 40 funded External Projects; (2) mentor new research staff in the OC; (3) refine and adapt ser- vices to meet program needs; (4) advise and support investigators on study operations, reporting, and compli- ance with NIH requirements; (5) broaden the impact of the core by disseminating innovative software products; and (6) enhance our research informatics infrastructure by working with the OAIC Coordinating Center to iden- tify funding sources that will permit the further expansion of the Yale Study Support Suite (YES3). The YES3 software will serve as an integral part of study operations support for OAIC projects, and with continued expan- sion through the proposed Development Project (DP-1), will provide additional tools for analysis, reporting, and monitoring. The goal of DP-1 is to build the YES3 Datamart REDCap External Module (EM), innovative soft- ware that will integrate with the YES3 Exporter, an EM developed during the current funding cycle. The new Datamart EM will further support analysis, monitoring, and reporting of OAIC studies and will be designed to be compatible with future YES3 components that share data with sponsor and regulatory agencies.

运营核心（OC）通过招募老年人来支持多因素老年疾病的研究 他们是多样化的和有代表性的，让社区的老年人作为利益攸关方参与进来，监测 参与者的安全，提供支持老龄化研究的资源，设计电子数据收集系统， 产生高质量数据的项目，开发软件应用程序以支持研究工作流程和分析， 收集，准备和报告数据，说明多因素老龄化研究的复杂性。 OC（RC 1）的总体目标是确保多因素老龄化研究的成功实施。 这一目标将通过与审调处调查员和研究人员协调努力来实现。的 具体目标是：（1）提供服务，以实现OAIC资助的目标和其他老龄化问题， （2）支持领导这些项目的研究人员的基础设施;（2）合作， 需要改进实地、数据管理和信息学方法，以推进以老龄问题为重点研究， 多因素老年病，并促进下一代以老龄化为重点的投资的发展， （3）开展创新的发展项目，推进耶鲁OAIC的使命。 在当前的资助周期（2018年至今），OC为16个OAIC资助的项目提供了研究支持。 项目和35个外部项目，就实地和数据管理计划与116名耶鲁研究人员进行了磋商 为项目和赠款提交，被授予NIH补充资金，以建立一个创新的软件套件， 软件工具称为耶鲁大学研究支持套件，并与其他胡椒中心和NIA-spon- 在研究项目、提供教育研讨会和软件传播方面提供服务。这些OC 这些努力已经产生了129种出版物和30多个额外资助的赠款，总额超过1.5亿美元- 狮子.在下一个资助周期内，法团将：（1）就6个建议的资源环境中心和公共教育服务中心项目中的5个项目进行合作 和40个资助的外部项目中的34个;（2）指导OC的新研究人员;（3）改进和调整服务， 满足项目需求的服务;（4）就研究操作、报告和投诉向研究者提供建议和支持， （5）通过传播创新的软件产品扩大核心的影响; 和（6）通过与OAIC协调中心合作，加强我们的研究信息基础设施， 确定资金来源，这将使耶鲁大学研究支持套件（YES 3）的进一步扩大。YES3 软件将作为OAIC项目研究操作支持的一个组成部分，并将继续扩展， 通过拟议的发展项目（DP-1），将提供额外的分析，报告和 监测. DP-1的目标是构建YES 3 Datamart REDCap外部模块（EM），这是一种创新的软 该软件将与YES 3 Exporter集成，YES 3 Exporter是在当前融资周期中开发的EM。新 Datamart EM将进一步支持OAIC研究的分析、监测和报告， 与将来与申办者和监管机构共享数据的YES 3组件兼容。