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The Effects of Diet on the Gut Microbiome and Short Chain Fatty Acids

饮食对肠道微生物组和短链脂肪酸的影响

基本信息

批准号：
10891964
负责人：
NOEL T MUELLER
金额：
$ 11.25万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2018
资助国家：
美国
起止时间：
2018-05-01 至 2024-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/10891964
关键词：
Effects Diet Gut Microbiome Short

项目摘要

PROJECT ABSTRACT Noel Theodore Mueller, PhD, MPH, is an Assistant Professor of Epidemiology at the Johns Hopkins Bloomberg School of Public Health (JHSPH). He seeks a K01 Award to obtain the skill set, knowledge and mentored research experience critical for his transition from an early career scientist adept in conducting secondary data analyses in observational epidemiologic cohorts to an independent scientist who analyzes and conducts trials designed to intervene on microbial communities that contribute to cardiometabolic disease. Two essential components of his transition into research independence are hands-on mentored training in 1) the conduct and design of clinical trials and translational microbiome experiments and 2) the analysis and interpretation of high-dimensional microbiome data. The proposed K01 Career Development plan will accomplish these goals. One of the most exciting areas of investigation related to prevention of cardiometabolic disease pertains to the etiologic role of the diet-gut microbiome relationship. Research on the gut microbiome as a target for prevention and therapy is an intriguing arena for public health because unlike the human genome, the gut microbiome is modifiable. Observational studies, murine models and small trials suggest dietary factors may exert many of their health effects in the host through modification of the gut microbiota. However, large rigorous trials in humans are needed to determine the effect of diet interventions on the gut microbiota, and whether changes to the gut microbiota associate with treatment-related improvements in cardiometabolic health. The overall objective of this application is to examine the effects of dietary interventions on the gut microbiota and their short chain fatty acid metabolites in racially-diverse participants in randomized trial settings. A secondary objective is to explore if diet-induced changes in the gut microbiota and their metabolites are associated with changes in blood pressure. Dr. Mueller will carry out this research in the rich training environment of the Johns Hopkins Welch Center for Prevention, Epidemiology and Clinical Research and the JHSPH Department of Epidemiology, under the collaborative and supportive mentorship of Dr. Lawrence Appel, MD, MPH, Director of the Welch Center and Professor of Medicine and Epidemiology at the JHSOM and JHSPH; and co-mentor Dr. Cynthia Sears, MD, Professor of Medicine in the Division of Infectious Disease and Gastroenterology. With the support of Dr. Mueller’s mentor, co-mentor and advisors, he is well positioned to complete the proposed activities. In addition to leading this research, Dr. Mueller will attend courses, workshops, seminars, scientific meetings, and participate in weekly study activities with his mentors. This mentored training will enable Dr. Mueller to grow into an independent researcher, with expertise in the design, conduct and analysis of microbiome studies, focused on understanding the intersecting role of nutrition and the microbiome in cardiometabolic diseases.

项目摘要 Noel Theodore Mueller 博士、公共卫生硕士是约翰霍普金斯大学彭博公共卫生学院 (JHSPH) 流行病学助理教授。他寻求获得 K01 奖，以获得技能、知识和受指导的研究经验，这对于他从一名擅长在观察流行病学队列中进行二次数据分析的早期职业科学家转变为一名独立科学家来说至关重要，该科学家分析和开展旨在干预导致心脏代谢疾病的微生物群落的试验。他过渡到研究独立性的两个重要组成部分是实践指导培训，1）临床试验和转化微生物组实验的进行和设计，2）高维微生物组数据的分析和解释。拟议的 K01 职业发展计划将实现这些目标。与预防心脏代谢疾病相关的最令人兴奋的研究领域之一涉及饮食与肠道微生物组关系的病因作用。将肠道微生物组作为预防和治疗目标的研究对于公共卫生来说是一个有趣的领域，因为与人类基因组不同，肠道微生物组是可修改的。观察性研究、小鼠模型和小型试验表明，饮食因素可能通过改变肠道微生物群对宿主产生许多健康影响。然而，需要对人类进行大规模严格的试验来确定饮食干预对肠道微生物群的影响，以及肠道微生物群的变化是否与治疗相关的心脏代谢健康改善相关。本申请的总体目标是在随机试验环境中检查饮食干预对不同种族参与者的肠道微生物群及其短链脂肪酸代谢物的影响。第二个目标是探索饮食引起的肠道微生物群及其代谢物的变化是否与血压变化相关。 Mueller 博士将在约翰·霍普金斯韦尔奇预防、流行病学和临床研究中心以及 JHSPH 流行病学系丰富的培训环境中，在韦尔奇中心主任、JHSOM 和 JHSPH 医学和流行病学教授 Lawrence Appel 博士（医学博士、公共卫生硕士）的协作和支持指导下开展这项研究；共同导师 Cynthia Sears 博士（医学博士、传染病和胃肠病学系医学教授）。在穆勒博士的导师、共同导师和顾问的支持下，他完全有能力完成拟议的活动。除了领导这项研究之外，穆勒博士还将参加课程、讲习班、研讨会、科学会议，并与导师一起参加每周的学习活动。这项指导培训将使 Mueller 博士成长为一名独立研究人员，拥有微生物组研究的设计、实施和分析方面的专业知识，重点是了解营养和微生物组在心脏代谢疾病中的交叉作用。

项目成果

期刊论文数量（19）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Bacterial Baptism: Scientific, Medical, and Regulatory Issues Raised by Vaginal Seeding of C-Section-Born Babies.

DOI：
10.1177/1073110519897732
发表时间：
2019-12
期刊：
The Journal of law, medicine & ethics : a journal of the American Society of Law, Medicine & Ethics
影响因子：
0
作者：
Mueller NT;Hourigan SK;Hoffmann DE;Levy L;von Rosenvinge EC;Chou B;Dominguez-Bello MG
通讯作者：
Dominguez-Bello MG

Absence of the Association of Blood Pressure With Age in a Remote Venezuelan Population Renews the Call for Population-Wide Interventions-Reply.

委内瑞拉偏远地区人口血压与年龄之间缺乏关联，再次呼吁进行全民干预-答复。