Core 1: Facility Management, Maintenance and Operations Core

核心 1：设施管理、维护和运营核心

• 批准号: 10791948
• 负责人: Colin S. Duckett
• 金额: $ 93.32万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10791948
• 关键词: 2019-nCoV; Alphavirus; Animal Model; Applied Research; Area; Basic Science; Biological; Biological Assay; Cellular Assay; Certification; Communicable Diseases; Containment; Contractor; Coronavirus; Cytomegalovirus; Dedications; Diagnostic; Disease Outbreaks; Ebola; Elements; Ensure; Equipment; Equipment and supply inventories; Event; Failure; Fee-for-Service Plans; Ferrets; Flavivirus; Funding; Goals; HIV; Hamsters; Hemagglutination; Home; Human; Immune response; Immunology; In Vitro; Infection; Infectious Diseases Research; Influenza; Laboratories; Leadership; Longevity; Maintenance; Malaria; Microbiology; Mission; Molecular; Mus; Mycobacterium tuberculosis; National Institute of Allergy and Infectious Disease; Oryctolagus cuniculus; Pharmaceutical Preparations; Poxviridae; Process; Proteins; Protocols documentation; Publications; Readiness; Research; Research Design; Research Personnel; Research Support; Resource Development; Safety; Schedule; Secure; Serology; Services; Societies; System; Therapeutic; Time; Training; Training Support; Translational Research; Trust; Tuberculosis; United States National Institutes of Health; Universities; Vaccines; Vendor; Viral Load result; Virus; Workforce Development; Yersinia pestis; ZIKA; animal imaging; biodefense; biosecurity; design; experience; future pandemic; global health; immune reconstitution; improved; in vivo; influenzavirus; instrumentation; laboratory facility; multiplex assay; novel vaccines; operation; pathogen; programs; repaired; risk minimization; square foot; virology

ABSTRACT- Facility Management, Maintenance and Operations Core (Core 1) To serve the primary mission of the Duke RBL, it is imperative that the facility itself operates to the highest operational standards. The overall goal of this Aim is to ensure that we can maintain reliable and uninterrupted facility functionality. To achieve this goal, we focus on several critical elements: the facility must be safely and effectively operated through a functional and seamless management process, inculcating a culture of safety that permeates throughout the entire organization; the systems that are vital to the operation of the facility must be well-maintained, and where appropriate the scheduled replacement of key systems must be planned prior to any likely systems failure (i.e. before the end of the lifespan of the system or equipment). Finally, and consistent with the aforementioned culture of safety, it is essential that facility meets or exceeds all of the regulatory standards that are required for all of our systems and equipment. The goals of this Facility Management, Maintenance and Operations Core (Core 1) are to 1) provide expert management and oversight of the BSL-3 space; 2) ensure proper preventative maintenance of all critical systems; and 3) ensure continuous compliance with all applicable regulatory standards. This Core is foundational to the safe and effective operation of the Duke RBL core, and as with all programs dedicated to managing and minimizing risk, embodies a culture of iterative improvement and the highest of operating standards.

摘要-设施管理、维护和运营核心（核心1） 为了服务于杜克RBL的主要使命，该设施本身必须以最高的标准运行 业务标准。这个目标的总体目标是确保我们能够保持可靠和不间断的 设施功能。为了实现这一目标，我们关注几个关键要素：设施必须安全， 通过有效和无缝的管理流程有效运作，灌输安全文化 渗透到整个组织;对设施运行至关重要的系统必须 维护良好，并且在适当情况下，必须提前计划关键系统的定期更换 任何可能的系统故障（即在系统或设备的使用寿命结束之前）。最后也是 与上述安全文化相一致，设施必须满足或超过 我们所有系统和设备所需的监管标准。本基金的目标 管理、维护和运营核心（核心1）将1）提供专家管理和监督 BSL-3空间; 2）确保所有关键系统的适当预防性维护;以及3）确保 持续遵守所有适用的监管标准。此核心是安全的基础， 杜克RBL核心的有效运作，以及与所有致力于管理和最小化风险的计划一样， 体现了迭代改进的文化和最高的操作标准。