Midbrain Circuits for Perceptual Decision-Making
用于感知决策的中脑回路
基本信息
- 批准号:10792130
- 负责人:
- 金额:$ 5.55万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2023
- 资助国家:美国
- 起止时间:2023-07-01 至 2024-04-30
- 项目状态:已结题
- 来源:
- 关键词:AgingAlzheimer&aposs DiseaseArbitrationAttention deficit hyperactivity disorderBehavioralBrainBrain regionCalciumCellsComputer ModelsDataDecision MakingDecision TheoryDevelopmentDiseaseDissectionDorsalExperimental DesignsFoundationsFutureGoalsHumanImageImpairmentKnowledgeLabelLinkMeasuresMidbrain structureModelingMotorMusNeurodevelopmental DisorderNeuronsParkinson DiseasePeroxidasesPhysiologicalPhysiologyPrimatesPsychophysicsResearchResearch PersonnelRoleSchizophreniaSeriesSliceSynapsesTechniquesTupaiidaeViralVisualautism spectrum disorderbehavior measurementcell typecognitive abilitycognitive functiondaily functioningexperimental studymild cognitive impairmentneuralnoveloptogeneticssuperior colliculus Corpora quadrigeminatwo-photon
项目摘要
ABSTRACT
Perceptual decision-making is a fundamental cognitive ability that is vital to healthy, daily functioning and is
impaired in many diseases. Although many brain regions are known to be involved, there is no clear brain-wide
model of how perceptual decisions are formed and executed and the underlying circuit mechanisms are still
largely unknown. Here, a team of investigators propose a series of experiments that will use behavioral
measures, imaging, physiology, circuit dissection, and computational modeling to study how the midbrain
superior colliculus (SC) participates in visual decision-making. Specifically, this new team of investigators will
probe the contribution of two SC neuronal cell types, wide field vertical (WFV) cells in the visuosensory layers
and predorsal bundle (PDB) cells in the motor layers. These experiments will be done in mice and tree shrews,
to reveal the underlying circuits and computational principles across species and to lay the foundation for future
experiments designed to dissect decision-making circuits in primates. In Aim 1, the investigators will establish
and perform psychophysical experiments to assess perceptual decision-making in both species. The behavioral
data will be fitted with computational models to arbitrate between different theories of decision-making. In Aim 2,
two photon calcium imaging and/or physiological recording will be performed in mice and tree shrews to
determine the activity of WFV and PDB neurons during the psychophysical measures established in Aim 1. In
addition, WFV and PDB neurons will be silenced optogenetically during the behavioral tasks to reveal their
specific roles in decision-making. In Aim 3, the investigators will use intersectional monosynaptic viral tracing
techniques, multiplexed peroxidase labeling for confocal and ultrastructural analysis of synaptic connections and
and optogenetics-assisted brain slice recording to investigate the intrinsic and extrinsic circuits that link WFV
and PDB cells. Together, these experiments will generate novel knowledge of the synapse to circuit mechanisms
underlying perceptual decision-making, and provide technical and theoretical foundations for future mechanistic
studies of cognitive function in higher mammalian species directly relevant to humans.
摘要
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
3D electron microscopy and volume-based bouton sorting reveal the selectivity of inputs onto geniculate relay cell and interneuron dendrite segments.
- DOI:10.3389/fnana.2023.1150747
- 发表时间:2023
- 期刊:
- 影响因子:2.9
- 作者:
- 通讯作者:
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MARTHA E BICKFORD其他文献
MARTHA E BICKFORD的其他文献
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{{ truncateString('MARTHA E BICKFORD', 18)}}的其他基金
The Influence of the Pretectum on the Visual Thalamus
前顶盖对视觉丘脑的影响
- 批准号:
10748541 - 财政年份:2023
- 资助金额:
$ 5.55万 - 项目类别:
KY INBRE Admin Supplement: The Role of Platinum Leaving Ligands in Chemo-immunotherapeutic Resistance in Lung Cancer Models
KY INBRE 管理补充:铂离去配体在肺癌模型化疗免疫治疗耐药中的作用
- 批准号:
10399834 - 财政年份:2021
- 资助金额:
$ 5.55万 - 项目类别:
GABAergic circuit interactions within the behaving mouse dLGN
行为小鼠 dLGN 内 GABA 能电路的相互作用
- 批准号:
9449526 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别:
GABAergic circuit interactions within the behaving mouse dLGN
行为小鼠 dLGN 内 GABA 能电路的相互作用
- 批准号:
9568835 - 财政年份:2017
- 资助金额:
$ 5.55万 - 项目类别: