Parallel Pulvinar Pathways

平行的枕小路

基本信息

  • 批准号:
    10621175
  • 负责人:
  • 金额:
    $ 49.21万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY / ABSTRACT The concept of parallel pathways that code different aspects of the visual scene has led to many key insights regarding the functional organization of the visual system. Inspired by this concept, the proposed studies focus on parallel visual pathways from the retina to the superior colliculus (SC) through the pulvinar nucleus (PUL). Projections from the SC to the PUL originate from motion-detecting widefield vertical (WFV) cells, and their synaptic organization defines two distinct PUL subdivisions: one that receives ipsilateral topographic WFV projections (“specific”), and one that is innervated by bilateral convergent WFV projections (“diffuse”). These two WFV innervation patterns are correlated with distinct cortical and subcortical connections, as well a variety of histochemical criteria, suggesting that the tectorecipient PUL may be organized into separate visual movement processing streams. However, we currently lack a functional framework that allows us to test this hypothesis and decipher the modular organization of the PUL. We plan to address this gap in knowledge by defining PUL cell types and synaptic inputs in the context of their functional properties. Our guiding hypothesis is that the PUL is composed of two distinct modules that coordinate visual perception with body movements or motivational state to initiate appropriate motor commands. To begin to test this theory, with mice as our animal model, we will use anatomical intersectional viral vector approaches and in vitro whole cell recordings coupled with dual optogenetic activation of cortical and WFV synaptic inputs to define circuit mechanisms that can alter firing properties within each PUL module (Aim 1). We will use in vivo extracellular recordings coupled with optogenetic activation and silencing of synaptic inputs to determine how circuit interactions within each PUL module adjusts receptive field properties (Aim 2). A key innovation of our experiments is the ability to identify PUL neuron subtypes by their unique frequency-dependent responses to optogenetic activation of WFV inputs (“neuron identification via single input dynamics”). This new method will allow us to link detailed in vitro circuit dissection techniques with in vivo recording of visual response properties, providing a framework of PUL function that has thus far been elusive. By comparing two parallel PUL modules, our goal is to understand how visual motion signals are parsed to initiate appropriate behavioral responses.
项目摘要/摘要

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

数据更新时间:{{ journalArticles.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ monograph.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ sciAawards.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ conferencePapers.updateTime }}

{{ item.title }}
  • 作者:
    {{ item.author }}

数据更新时间:{{ patent.updateTime }}

MARTHA E BICKFORD其他文献

MARTHA E BICKFORD的其他文献

{{ item.title }}
{{ item.translation_title }}
  • DOI:
    {{ item.doi }}
  • 发表时间:
    {{ item.publish_year }}
  • 期刊:
  • 影响因子:
    {{ item.factor }}
  • 作者:
    {{ item.authors }}
  • 通讯作者:
    {{ item.author }}

{{ truncateString('MARTHA E BICKFORD', 18)}}的其他基金

The Influence of the Pretectum on the Visual Thalamus
前顶盖对视觉丘脑的影响
  • 批准号:
    10748541
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
Midbrain Circuits for Perceptual Decision-Making
用于感知决策的中脑回路
  • 批准号:
    10792130
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
Midbrain circuits for perceptual decision-making
用于感知决策的中脑回路
  • 批准号:
    10216482
  • 财政年份:
    2021
  • 资助金额:
    $ 49.21万
  • 项目类别:
KY INBRE Admin Supplement: The Role of Platinum Leaving Ligands in Chemo-immunotherapeutic Resistance in Lung Cancer Models
KY INBRE 管理补充:铂离去配体在肺癌模型化疗免疫治疗耐药中的作用
  • 批准号:
    10399834
  • 财政年份:
    2021
  • 资助金额:
    $ 49.21万
  • 项目类别:
Parallel Pulvinar Pathways
平行的枕小路
  • 批准号:
    10393516
  • 财政年份:
    2020
  • 资助金额:
    $ 49.21万
  • 项目类别:
GABAergic circuit interactions within the behaving mouse dLGN
行为小鼠 dLGN 内 GABA 能电路的相互作用
  • 批准号:
    9449526
  • 财政年份:
    2017
  • 资助金额:
    $ 49.21万
  • 项目类别:
GABAergic circuit interactions within the behaving mouse dLGN
行为小鼠 dLGN 内 GABA 能电路的相互作用
  • 批准号:
    9568835
  • 财政年份:
    2017
  • 资助金额:
    $ 49.21万
  • 项目类别:
Parallel Tectothalamic Pathways
平行的顶盖丘脑通路
  • 批准号:
    9816337
  • 财政年份:
    2014
  • 资助金额:
    $ 49.21万
  • 项目类别:
Parallel Tectothalamic Pathways
平行的顶盖丘脑通路
  • 批准号:
    8759227
  • 财政年份:
    2014
  • 资助金额:
    $ 49.21万
  • 项目类别:
Parallel Tectothalamic Pathways
平行的顶盖丘脑通路
  • 批准号:
    9129777
  • 财政年份:
    2014
  • 资助金额:
    $ 49.21万
  • 项目类别:

相似海外基金

Linking Epidermis and Mesophyll Signalling. Anatomy and Impact in Photosynthesis.
连接表皮和叶肉信号传导。
  • 批准号:
    EP/Z000882/1
  • 财政年份:
    2024
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Fellowship
Digging Deeper with AI: Canada-UK-US Partnership for Next-generation Plant Root Anatomy Segmentation
利用人工智能进行更深入的挖掘:加拿大、英国、美国合作开发下一代植物根部解剖分割
  • 批准号:
    BB/Y513908/1
  • 财政年份:
    2024
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Research Grant
Simultaneous development of direct-view and video laryngoscopes based on the anatomy and physiology of the newborn
根据新生儿解剖生理同步开发直视喉镜和视频喉镜
  • 批准号:
    23K11917
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Grant-in-Aid for Scientific Research (C)
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
OSA 极端表型的遗传学及相关上呼吸道解剖学
  • 批准号:
    10555809
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
computational models and analysis of the retinal anatomy and potentially physiology
视网膜解剖学和潜在生理学的计算模型和分析
  • 批准号:
    2825967
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Studentship
Computational comparative anatomy: Translating between species in neuroscience
计算比较解剖学:神经科学中物种之间的翻译
  • 批准号:
    BB/X013227/1
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Research Grant
Doctoral Dissertation Research: Social and ecological influences on brain anatomy
博士论文研究:社会和生态对大脑解剖学的影响
  • 批准号:
    2235348
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Standard Grant
Development of a novel visualization, labeling, communication and tracking engine for human anatomy.
开发一种新颖的人体解剖学可视化、标签、通信和跟踪引擎。
  • 批准号:
    10761060
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
Understanding the functional anatomy of nociceptive spinal output neurons
了解伤害性脊髓输出神经元的功能解剖结构
  • 批准号:
    10751126
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
Anatomy and functions of LTP interactomes and their relationship to small RNA signals in systemic acquired resistance
LTP相互作用组的解剖和功能及其与系统获得性耐药中小RNA信号的关系
  • 批准号:
    BB/X013049/1
  • 财政年份:
    2023
  • 资助金额:
    $ 49.21万
  • 项目类别:
    Research Grant
{{ showInfoDetail.title }}

作者:{{ showInfoDetail.author }}

知道了