Regenerative Engineering Training Program (RE-Training)

再生工程培训计划（RE-Training）

• 批准号: 10424463
• 负责人: Guillermo Antonio Ameer
• 金额: $ 21.28万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10424463
• 关键词: Regenerative engineering; Training; Training Programs

Summary for the Regenerative Engineering Training Program A major health challenge that our society faces is premature death and morbidity associated with the shortage of healthy donor tissues or organs for transplantation and the limited regenerative capacity of our body due to serious injury or disease. Research that entails the convergence of disparate disciplines to create new frameworks, tools, and a new common language is positioned to better enable solutions to complex problems such as the aforementioned one. Regenerative engineering is the convergence of advanced materials science, stem cell and developmental biology, physical sciences, and translational medicine to reconstruct or regenerate complex tissues and organs. The objective of this training program is to offer the curriculum and environment needed to train the next generation of convergence researchers that are versed in the development and use of regenerative engineering solutions. Specifically, program graduates will have the capacity to develop scientific, technical, and clinical knowledge and skills that will enable them to recognize and solve challenges associated with the restoration of tissue and organ function. Core innovative elements of the program include: 1) clinical immersion rotations to gain direct insight into organ failure and tissue reconstruction challenges that afflict patients and physicians; 2) a 3-member mentorship team that includes 1 clinical, 1 life/physical sciences, and 1 engineering faculty member; 3) internships at companies with product development expertise involving regenerative engineering; and 4) experiential courses to learn essential experimental techniques. The program, housed in the Center for Advanced Regenerative Engineering at Northwestern University, will be a joint effort involving diverse faculty from the schools of engineering, arts and sciences, and medicine. Northwestern University has a long history of transdisciplinary collaborations and has the resources and pedagogical tools to establish a unique national program to train new leaders. Trainees will be mentored by preceptors working in molecular and stem cell biology, nanotechnology, additive manufacturing, regenerative engineering, molecular biophysics, biomaterials, bioelectronics, surgery, and translational medicine. Examples of ongoing collaborations include programs for the regeneration of bladder, bone, blood vessels, pancreas, liver, kidney, skin, muscle, the immune system, and nerves. We propose to train 3 pre-doctoral trainees in year 1 and 6 trainees for each of years 2-5. Trainees will be selected from applicants in the department of Biomedical Engineering, including those from the medical scientist training program. We expect to produce the next generation of regenerative engineering thought leaders that are competent in convergence research aimed at tackling the aforementioned societal health challenges and improving patient outcomes.

再生工程培训计划总结 我们社会面临的一个主要健康挑战是过早死亡和与疾病相关的发病率。 缺乏用于移植的健康供体组织或器官， 我们的身体由于严重的伤害或疾病。需要融合不同学科的研究 创建新的框架、工具和新的通用语言，以更好地实现解决方案 解决上述复杂问题。再生工程是一种 先进的材料科学，干细胞和发育生物学，物理科学， 转化医学用于重建或再生复杂的组织和器官。的目的 培训计划是提供培训下一代所需的课程和环境， 精通再生工程开发和使用的融合研究人员 解决方案具体而言，计划毕业生将有能力发展科学，技术和 临床知识和技能，使他们能够认识和解决与 组织和器官功能的恢复。该计划的核心创新要素包括：1）临床 浸泡旋转，以获得对器官衰竭和组织重建挑战的直接洞察， 折磨病人和医生; 2）一个由3名成员组成的导师团队，包括1名临床，1名生活/物理 科学，和1名工程教员; 3）在产品开发公司实习 涉及再生工程的专业知识;和4）体验课程，学习基本的 实验技术该项目位于高级再生工程中心， 在西北大学，将是一个共同的努力，涉及来自工程学院， 艺术、科学和医学。西北大学具有悠久的跨学科历史 合作，并拥有资源和教学工具，以建立一个独特的国家计划， 培养新的领导者。学员将由分子和干细胞生物学方面的导师指导， 纳米技术，增材制造，再生工程，分子生物物理学，生物材料， 生物电子学、外科手术和转化医学。正在进行的合作包括 膀胱，骨骼，血管，胰腺，肝脏，肾脏，皮肤，肌肉， 免疫系统和神经我们建议在第一年培训3名博士预科学员和6名学员 每年2-5。学员将从生物医学系的申请者中挑选 工程，包括那些从医学科学家培训计划。我们希望生产出 下一代再生工程思想领袖，能够胜任融合 研究旨在解决上述社会健康挑战，并改善患者 结果。