Neurocognitive Aging, Health Disparities Research and Education

神经认知衰老、健康差异研究与教育

• 批准号: 10792119
• 负责人: Meredith Nicole Braskie
• 金额: $ 20.72万
• 依托单位: CALIFORNIA STATE UNIVERSITY FULLERTON
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-06-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10792119
• 关键词: Address; African American population; Aging; Alaska Native; Alcohol consumption; Alleles; Alzheimer' s Disease; Alzheimer' s disease related dementia; Alzheimer' s disease risk; American Indians; Amyloid beta-Protein; Apolipoprotein E; Asian; Biological; Biological Factors; Black Populations; Brain; Cohort Studies; Data; Data Coordinating Center; Data Set; Dementia; Diabetes Mellitus; Disparity; Education; Educational Curriculum; Educational workshop; Environment; Epigenetic Process; Ethnic Origin; Ethnic Population; Evaluation; Family; Feedback; Genetic; Genetic Risk; Goals; Growth; Health; Health Disparities Research; Hispanic; Hispanic Populations; Hypertension; Image; Impaired cognition; Incidence; Individual; Investigation; Knowledge; Life Style; Machine Learning; Mentorship; Meta-Analysis; Metabolic; Mexican Americans; Minority Groups; Modernization; Neurocognitive; Not Hispanic or Latino; Obesity; Outcome; Pacific Islander; Persons; Physical activity; Population; Population Heterogeneity; Program Accessibility; Proteins; Race; Recommendation; Research; Risk; Risk Factors; Series; Societies; Source; Structure; Students; Techniques; Testing; Time; Tobacco use; Training; United States; big-data science; brain health; cloud based; comorbidity; complex data; data access; dementia risk; disorder prevention; education research; equity, diversity, and inclusion; ethnic difference; ethnic diversity; gene environment interaction; health disparity; health equity; hormone related cancer; lifestyle factors; mild cognitive impairment; modifiable risk; racial difference; racial population; social; socioeconomics; sound; student training; tau Proteins; tool; usability

Abstract. The stark disparities in Alzheimer’s Disease and Related Dementia (ADRD) incidence and outcomes across racial and ethnic groups are urgent issues necessitating further research. We also need further investigation in identifying and deciphering both modifiable risk factors, including obesity, physical activity, socioeconomic environments, as well as genetics and/or the combined effect of gene-environment interactions associated with neurocognitive aging deficits in diverse populations. The availability of open-access data allows us the opportunity to more readily address multiple variables and factors associated with neurocognitive aging across various ethnic/racial groups. Therefore, this supplement aims to examine ADRD health disparities within and between racial/ethnic groups via leveraging large open-access datasets, as well as develop corresponding curricula workshops. (1). Research Aims: To examine the association between modifiable risk factors, ADRD markers (genetic, protein and imaging), gene-by-environment interactions, and co-morbid conditions with neurocognitive aging and ADRD outcomes across racial/ethnic groups in three large open-access data: the National Alzheimer’s Coordinating Center (NACC), the Global Alzheimer’s Association Interactive Network (GAAIN) and All of Us. 1a. To investigate, via the NACC dataset, the relationship between co-morbid conditions, such as diabetes, hypertension, hormone-related cancers with mild cognitive impairment (MCI) and dementia (specifically AD) within and between NHW, Hispanic and Black groups. Hypothesis: Co- morbid conditions are associated with MCI and AD dementia, and that the relationship varies between racial/ethnic groups. 1b. To investigate, via GAAIN, the association between obesity and APOE4, ADRD markers (beta-amyloid (Aß), tau and brain structure) and respective epigenetic risk factors with ADRD outcomes across the Hispanic diaspora. Hypothesis: Obesity and APOE4, ADRD markers [beta-amyloid (Aß), tau and brain structure] are associated with ADRD, and varies across the Hispanic diaspora globally. 1c. To explore, via All of Us, the association between obesity, physical activity and socioeconomic risk factors with dementia and dementia across NHW, Hispanics and Blacks. Hypothesis: Obesity, physical activity and socioeconomic risk factors are associated with dementia and will vary by race/ethnicity. Where feasible, all hypotheses will be tested and compared across all three datasets. In addition, we will apply both traditional and modern machine learning techniques to these datasets. (2). Training Aim: To develop curricula for utilization, access, data content, and exploratory analyses of the three open-access datasets/platforms. The curricula will be offered and evaluated via workshops for diverse CSUF students (n = 10 per three workshop series). Diversity, Equity, Inclusion and Accessibility (DEIA) program and mentorship components will be evaluated as well.

抽象的。阿尔茨海默病和相关痴呆（ADRD）发病率和结局的明显差异 种族和族裔群体之间的差异是需要进一步研究的紧迫问题。我们还需要进一步 在确定和破译两个可改变的风险因素，包括肥胖，体育活动， 社会经济环境，以及遗传学和/或基因-环境相互作用的综合效应 与不同人群的神经认知老化缺陷有关。开放获取数据的可用性 使我们有机会更容易地解决与神经认知相关的多个变量和因素， 不同种族/民族群体的老龄化。因此，本补充旨在检查ADRD健康 通过利用大型开放获取数据集， 制定相应的课程讲习班。（一）.研究目的：研究 可改变的风险因素、ADRD标志物（遗传、蛋白质和成像）、基因与环境的相互作用，以及 在三个大型研究中，不同种族/民族的神经认知老化和ADRD结局的共病情况 开放获取数据：国家阿尔茨海默病协调中心（NACC），全球阿尔茨海默病协会 互动网络（GAAIN）和我们所有人。1a.通过NACC数据集调查 合并症，如糖尿病、高血压、与轻度认知障碍相关的癌症 (MCI)以及NHW、西班牙裔和黑人群体内部和之间的痴呆症（特别是AD）。假设：Co- 病态与MCI和AD痴呆相关，并且这种关系在 种族/民族团体。1b.通过GAAIN研究肥胖与APOE 4、ADRD之间的关系 标记物（β-淀粉样蛋白（AAPs）、tau蛋白和脑结构）和ADRD的相应表观遗传风险因素 在西班牙裔移民中的影响假设：肥胖与APOE 4、ADRD标志物[β-淀粉样蛋白（AAPOE）， tau蛋白和脑结构]与ADRD相关，并且在全球西班牙裔散居地之间变化。1c.到 通过All of Us探索肥胖，体育活动和社会经济风险因素之间的联系， NHW、西班牙裔和黑人的痴呆症和痴呆症。假设：肥胖、体力活动和 社会经济风险因素与痴呆症有关，并因种族/民族而异。在可行的情况下， 将对所有三个数据集的假设进行测试和比较。此外，我们将采用传统的 和现代机器学习技术来处理这些数据集。（二）、培训目标：开发课程 三个开放获取数据集/平台的利用、访问、数据内容和探索性分析。的 课程将通过讲习班为不同的CSUF学生提供和评估（每三个讲习班n = 10 系列）。多样性，公平，包容性和可访问性（DEIA）计划和导师组成部分将 也评价。