Diversity Supplement-Massoudi
Diversity Supplement-Massoudi
批准号:
10787059
负责人:
Myriam Marianne Chaumeil
金额:
$10.68万
依托单位国家:
美国
项目类别:
财政年份:
2019
资助国家:
美国
项目状态:
已结题
起止时间:
2019-09-18 至 2024-08-31
关键词:
AccelerationAddressAgeAge MonthsAlzheimer&aposs DiseaseAlzheimer&aposs disease related dementiaAnimal ModelAscorbic AcidAssociation LearningBehaviorBehavioralBiological AssayBiological MarkersBlood VesselsCADASILCalciumCell Surface ReceptorsCerebral small vessel diseaseCerebrumCharacteristicsClinicalCognitiveCognitive deficitsCountryDataDedicationsDementiaDevelopmentDiseaseDisease PathwayElectrophysiology (science)ElementsEnsureEtiologyEvaluationExperimental ModelsFemaleFunctional disorderGenesGeneticGenetic ModelsGoalsHumanImageImpaired cognitionInterventionKnowledgeLearningLesionMagnetic Resonance ImagingMediatingMemoryMeta-AnalysisMicroRNAsMicrocirculationMicrovascular DysfunctionModelingMolecularMusMutant Strains MiceMutationMyographyOutcomePathogenesisPathologyPathway interactionsPhasePhysiologicalPopulationPost-Transcriptional RegulationPre-Clinical ModelPreclinical TestingPrevention strategyProcessRadiology SpecialtyResearchStrokeSubgroupSyndromeTherapeutic InterventionValidationVascular Diseasesage relatedagedarterial tortuositybehavior testbrain circulationcerebral microbleedscerebrovascular pathologycognitive changecognitive functioncohortcomparativedesigneffective interventiongenetic resourcegenome wide association studygenome-wide analysishuman diseaseimaging modalityimaging studyimprovedinnovationinsightmalemouse modelneuropathologynovelpatch clamppressurepreventprospective testreceptor bindingvascular cognitive impairment and dementiawhite matter
中文摘要
项目摘要
血管性认知障碍和痴呆(VCID)是可归因于以下因素的任何水平的认知改变:
脑血管病VCID是仅次于阿尔茨海默病的痴呆症的第二大病因,
大约15-30%的痴呆病例。脑小血管疾病(cSVD)是一组影响脑血管疾病的病理学,
大脑的微循环,总共占所有中风的20%,是最常见的
VCID的病理学基础cSVD和VCID的影响预计将迅速增加,
美国和其他国家的年龄。重要的是,cSVD的发病机制尚未完全了解,
这是制定预防和治疗战略的一个主要障碍。本文中描述的研究
该提案将开发和验证五种新的cSVD小鼠模型,这些模型基于以下基因和突变:
被证明是导致人类疾病的原因。我们组建了一个跨学科的专家团队,
整合独特遗传资源、血管压力肌电描记术、膜片钳电生理学、钙
成像、专门的磁共振成像模式以及学习和记忆行为测定,
开发和表征cSVD的多种新型遗传模型,使用导致疾病的基因,
人类我们的长期目标是开发和采用遗传模型,忠实地概括重要的
人类cSVD和VCID的标志。
英文摘要
PROJECT SUMMARY
Vascular cognitive impairment and dementia (VCID) is any level of cognitive alteration that is attributable to
cerebrovascular pathologies. VCID is second only to Alzheimer’s disease as a cause of dementia and accounts
for ~15-30% of all dementia cases. Cerebral small vessel diseases (cSVDs) are group of pathologies afflicting
the microcirculation of the brain that collectively account for up to 20% of all strokes and is the most common
pathology underlying VCID. The impact of cSVD and VCID is expected to increase rapidly as the population of
the US and other countries ages. Importantly, the pathogeneses of cSVDs are incompletely understood which
represents a major barrier in developing strategies for prevention and treatment. Research described in this
proposal will develop and validate five novel mouse models of cSVD based on genes and mutations that are
demonstrated to contribute to human disease. We have assembled an interdisciplinary team of experts that will
integrate unique genetic resources, vascular pressure myography, patch-clamp electrophysiology, calcium
imaging, specialized magnetic resonance imaging modalities and learning and memory behavior assays to
develop and characterize multiple novel genetic models of cSVD using genes that contribute to disease in
humans. Our long-term objective is to develop and employ genetic models that faithfully recapitulate important
hallmarks of human cSVD and VCID.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Theranostic Metabolic Imaging of Oxidative Stress in Multiple Sclerosis.
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批准号:10666890
-
项目类别:
-
资助金额:$24.23万
-
财政年份:2023
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Imaging cerebral metabolic impairment in AD using Deuterium MRI
-
批准号:10608908
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项目类别:
-
资助金额:$71.92万
-
财政年份:2023
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Imaging innate and adaptive immune response in MS using using [18F]F-AraG PET and hyperpolarized 13C MRSI
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批准号:10040874
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项目类别:
-
资助金额:$28.25万
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财政年份:2020
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS Lymphoma
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批准号:10177970
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项目类别:
-
资助金额:$61.34万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS Lymphoma
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批准号:10437739
-
项目类别:
-
资助金额:$58.41万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
-
批准号:10471562
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项目类别:
-
资助金额:$79.66万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
-
批准号:10684902
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项目类别:
-
资助金额:$78.37万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
-
批准号:9894276
-
项目类别:
-
资助金额:$50.5万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Application of Hyperpolarized 13C Magnetic Resonance Imaging to Detect Target Inhibition of NF-kB Activation and Response in Primary CNS Lymphoma
-
批准号:10651730
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项目类别:
-
资助金额:$57.15万
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财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Understand and probing disrupted glucose metabolism in Alzheimer's disease
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批准号:9802793
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项目类别:
-
资助金额:$359.73万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
-
批准号:10021037
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项目类别:
-
资助金额:$56.07万
-
财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
Development and validation of novel models for cerebral small vessel disease and vascular cognitive impairment
-
批准号:10929709
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项目类别:
-
资助金额:$15.55万
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财政年份:2019
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
MR metabolic Imaging of Multiple Sclerosis
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批准号:9354640
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项目类别:
-
资助金额:$34.67万
-
财政年份:2017
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负责人:Myriam Marianne Chaumeil
-
依托单位:
MR metabolic Imaging of Multiple Sclerosis
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批准号:10162675
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项目类别:
-
资助金额:$34.67万
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财政年份:2017
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
MR metabolic Imaging of Multiple Sclerosis
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批准号:9927691
-
项目类别:
-
资助金额:$34.67万
-
财政年份:2017
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
MR Metabolic Imaging of Multiple Sclerosis
-
批准号:10736049
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项目类别:
-
资助金额:$64.54万
-
财政年份:2017
-
负责人:Myriam Marianne Chaumeil
-
依托单位:
In vivo metabolic imaging of neuroinflammation after TBI
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批准号:9107653
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项目类别:
-
资助金额:$23.78万
-
财政年份:2016
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负责人:Myriam Marianne Chaumeil
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依托单位:
海外基金