Further expansion of the Southwest National Primate Research Center Specific Pathogen Free Rhesus Macaque Resource

摘要 西南国家灵长类动物研究中心（SNPRC）饲养了一只无特定病原体（SPF）的恒河猴。 印度猕猴群（Ind RM），由NIH SPF恒河猴育种计划（U42 OD 010442）支持， 和较小的SPF P51支持的菌落。我们目前饲养了约1000只恒河猴，其中U42群 大约800只动物支持艾滋病相关的研究，无论是在SNPRC还是通过出售给艾滋病 其他机构的调查员。然而，研究非人灵长类动物的国家严重短缺， （NHP），特别是SPF Ind RM。这严重影响了我们支持国家和 艾滋病毒/艾滋病以及非艾滋病/其他传染病领域的国际研究使命， 共同感染，疟疾，结核病，COVID-19等。NIH已经认识到扩大SPF恒河猴的必要性 生产，并强烈建议增加IndRM育种能力。SNPRC处于有利地位， 扩大其SPF工业RM生产作为一个中心，位于一个气候好客，主要是户外住房， 具有扩展能力的机构。我们的主办机构Texas Biomed筹集了资金，目前正在建设 新的NHP设施将容纳约600名NHP。Texas Biomed/SNPRC也得到了NIH/ORIP的资助。 通过其他机制将我们的生产能力在现有能力的基础上扩大30%。最后通过 德克萨斯生物医学的支持，我们已经采购了约150个传统的创始人/育种者工业RM。这个创始人殖民地 增加了SNPRC猕猴群体管理团队可以产生的繁殖对的数量， 预计在即将到来的出生季节，将有约200 RM的活产，是上一个出生季节的两倍。 几年因此，SNPRC Ind RM人口在未来五年内可能增加到1500多人。资助 部分由这个C 06，我们寻求建立一个额外的动物住房/繁殖设施附近的两个新的 目前正在建设的饲养/繁殖设施，作为4500万美元长期动物护理计划的一部分 复杂的项目。这将进一步使我们能够容纳，繁殖和维持额外的供应约300个IndRM， 艾滋病/新发传染病研究。

Abstract The Southwest National Primate Research Center (SNPRC) houses a Specific Pathogen Free (SPF) rhesus macaque colony of Indian origin (Ind RM), supported by the NIH SPF rhesus breeding program (U42OD010442), and a smaller SPF P51 supported colony. We currently house ~1000 rhesus macaques, of which the U42 colony of approximately 800 animals supports AIDS-related research both at SNPRC and through sales to AIDS investigators at other institutions. However, there is a major national shortage of research nonhuman primates (NHPs), and particularly of SPF Ind RM. This has severely impacted our ability to support the national and international research mission of HIV/AIDS as well as in the area of non-AIDS/other infectious diseases, AIDS co-infections, malaria, TB, COVID-19, etc. The NIH has recognized this need for expansion of SPF rhesus production and strongly recommends increasing Ind RM breeding capacity. The SNPRC is well positioned to expand its SPF Ind RM production as a center located in a climate hospitable to largely outdoor housing, at an institution with capacity for expansion. Our host institution, Texas Biomed, raised funds and is currently building new NHP facilities which will house ~600 NHPs. Texas Biomed/SNPRC has also been funded by the NIH/ORIP to expand our production capacity by 30% over our existing capacity via other mechanisms. Finally, through Texas Biomed support, we have procured ~150 conventional founder/breeder Ind RM. This founder colony has increased the number of breeding pairs the SNPRC macaque colony management team can generate, and it is expected that in the upcoming birthing season, ~200 RM live births will occur, double that of each of the last several years. As such the SNPRC Ind RM population can increase to 1500+ in the next five years. Funded partially by this C06, we seek to construct an additional animal housing/breeding facility adjacent the two new holding/breeding facilities currently under construction, as part of the overall $45M long term Animal Care Complex project. This will further allow us to house, breed and maintain an additional supply of ~300 Ind RM for AIDS/emerging infectious diseases research.