Upgrading infectious disease research facilities at University of Louisville RBL

升级路易斯维尔大学 RBL 传染病研究设施

• 批准号: 10631406
• 负责人: KENNETH E PALMER
• 金额: $ 121.97万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-08-22 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631406
• 关键词: Administrative Supplement; Air; Communicable Diseases; Emerging Communicable Diseases; Equipment; Goals; Infectious Diseases Research; Kentucky; Laboratories; Laboratory Animal Production and Facilities; Laboratory Research; Link; Medicine; Modernization; National Institute of Allergy and Infectious Disease; PET/CT scan; Positron-Emission Tomography; Research; Research Infrastructure; Research Personnel; Research Subjects; Security; System; Therapeutic; Treatment Efficacy; Universities; biodefense; biothreat; data acquisition; end of life; improved; in vivo; infectious disease model; repaired; research facility; vaccine discovery

PROJECT SUMMARY The University of Louisville Regional Biocontainment Laboratory (RBL) is an operational unit of the University’s Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases (CPM). The CPM operates the only Biosafety Level 3 laboratories and animal research facilities available to researchers in the Commonwealth of Kentucky. We request support from NIAID through this proposal for additional facility related upgrades and modernization of research equipment. In this administrative supplement we are not proposing any new specific aims. First, we shall repair, renovate and modernize specific RBL building systems to enhance functions of the research facilities. In this administrative supplement we shall replace the end of life Continuum building access controls system with a Lenel system that meets our layered security access controls requirements. The building chillers, necessary for maintaining appropriately conditioned air to the laboratories and vivaria will have critical components that are near end of life replaced. The building air compressors are critical to the facility’s HVAC controls systems, and must be replaced. Secondly, we propose to enhance and modernize the CPM in vivo research facilities. In this administrative supplement we shall achieve our second aim by augmenting our in vivo research capabilities with new CT/PET imaging equipment that will allow fine granularity of data acquisition, improving our understanding of infectious disease, and assisting in discovery of vaccines and therapeutics against biothreats and emerging infectious diseases. This equipment achieves major goals of humane in vivo research: more comprehensive and detailed information about the infectious disease model and effect of therapy, closely linked with reduction in the number of research subjects necessary for comprehensive assessment of the treatment efficacy. The facility and equipment upgrades will modernize our research infrastructure, enhancing the CPM RBL capabilities to rapidly develop and assist in deployment of countermeasures to mitigate the effects of biothreats and emerging infectious diseases.

项目摘要 路易斯维尔大学区域生物防护实验室（RBL）是该大学的一个运营单位， 生物防御和新发传染病预测医学中心（CPM）。CPM操作 只有生物安全3级实验室和动物研究设施可供英联邦的研究人员使用 来自肯塔基州。我们请求NIAID通过本提案提供额外设施相关升级的支持， 研究设备的现代化。在这份行政补充文件中，我们没有提出任何新的具体建议。 目标。首先，我们将修复，翻新和现代化特定的RBL建筑系统，以增强 研究设施。在本行政补充文件中，我们将替换使用寿命结束的Continuum建筑入口 控制系统与Lenel系统，满足我们的分层安全访问控制要求。建筑 冷却器，必要的保持适当的空调空气的实验室和动物园将有关键的 更换接近使用寿命结束的组件。建筑空气压缩机对设施的HVAC至关重要 控制系统，必须更换。其次，我们建议在体内增强CPM并使其现代化 研究设施。在这个行政补充，我们将实现我们的第二个目标，通过增加我们的体内 研究能力与新的CT/PET成像设备，将允许细粒度的数据采集， 提高我们对传染病的理解，并协助发现疫苗和治疗方法 对抗生物威胁和新出现的传染病。该设备实现了人体内的主要目标 研究：更全面和详细的信息，传染病的模式和影响， 治疗，密切相关的研究课题的数量减少，需要全面 评估治疗效果。设施和设备的升级将使我们的研究现代化 基础设施，增强CPM RBL能力，以快速开发和协助部署 减轻生物威胁和新出现的传染病影响的对策。