CHOICES-TEEN: Efficacy of a Bundled Risk Reduction Intervention for Juvenile Justice Females

CHOICES-TEEN：针对青少年司法女性的捆绑风险降低干预措施的功效

• 批准号: 10796649
• 负责人: Danielle Elizabeth Parrish
• 金额: $ 9.92万
• 依托单位: BAYLOR UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-05-15 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10796649
• 关键词: Adolescent; Affect; Alcohols; Behavior; Collection; Complex; Data; Data Analyses; Equation; Evidence based intervention; Exposure to; Female; Goals; Growth; HIV/STD; Health; Imprisonment; Intervention; Intervention Studies; Interview; Justice; Life Experience; Logistic Regressions; Manuscripts; Marijuana; Mediating; Mentorship; Modeling; Population; Pregnancy; Preparation; Prevention Research; Qualitative Research; Regression Analysis; Research; Research Personnel; Risk; Risk Behaviors; Risk Reduction; Suggestion; Teenagers; Testing; United States National Institutes of Health; clinical trial analysis; efficacy evaluation; efficacy testing; ethnic minority; experience; high risk; high risk sexual behavior; juvenile justice system; novel; parent grant; sexual risk behavior; skills; substance use; treatment arm; treatment effect; young woman

Project Summary/Abstract Parent Grant: Adolescent young women involved with juvenile justice settings engage in multiple health risk behaviors that place them at risk for HIV/STIs and pregnancy affected by alcohol and marijuana. This study aims to test the efficacy of CHOICES-TEEN (CT) in reducing the risks of substance-exposed pregnancy (SEP) and HIV/STIs among juvenile justice-involved young women. Proposed Diversity Supplement: While a substantive portion of justice- involved adolescent young women have been exposed to parental incarceration, and these adolescents were at higher risk of substance use and sexual risk behaviors, extant interventions for at-risk adolescents demonstrate limited effects on those with parental incarceration experiences. This diversity supplement aims to determine the efficacy of CT for adolescent young women with parental incarceration experiences by additional quantitative analyses of data collected by the parent grant and collection and analysis of qualitative interview data from a subsample with parental incarceration experiences following completion of the final 9-month assessment. Specifically, Aim 1 will utilize multilevel logistic regression analyses and latent growth curve modeling to determine the potential differential efficacy of CT in reducing the risks of SEP and HIV/STIs among adolescent young women who have experienced parental incarceration. In Aim 2, multilevel Bayesian structural equation modeling will be employed to evaluate the mediating treatment effects of the mechanisms of action for CT by parental incarceration. In Aim 3, qualitative interviews will be conducted with 20 adolescent young women in the intervention arm to explore their lived experiences of parental incarceration that may impact the efficacy and acceptability of CT and collect their suggestions for adaptations. The proposed diversity supplement research serves as a natural extension of the parent grant while offering a novel opportunity for a promising new investigator to initiate a new line of prevention research focused on adolescents with parental incarceration experiences and receive mentorship from a strong team of experienced researchers. This diversity supplement will help the candidate gain skills and experience in intervention research, complex quantitative analysis of clinical trial data, qualitative research, and manuscript preparation. Moreover, data from this study will inform a K01 application on developing new or adapted interventions (such as CT) for adolescents with parental incarceration experiences, with the long-term goal of testing its efficacy in a larger R01 study. This diversity supplement will significantly contribute to the candidate’s trajectory to becoming an independent NIH researcher.

项目总结/摘要 家长补助金：青少年司法环境中的青少年年轻女性参与 多种健康风险行为，使她们面临感染艾滋病毒/性传播感染和怀孕的风险， 酒精和大麻本研究旨在测试CHOICES-TEEN（CT）在减少 青少年司法所涉及的物质暴露怀孕（SEP）和艾滋病毒/性传播感染的风险 年轻女性。拟议的多样性补充：虽然司法的实质性部分- 参与的青少年女性已经暴露在父母监禁，这些 青少年物质使用和性风险行为的风险较高，现有的干预措施 对那些父母被监禁的青少年的影响有限 经验这种多样性补充旨在确定CT对青少年的疗效 通过对有父母监禁经历的年轻女性进行额外的定量分析 通过父母补助金收集的数据以及从一个 完成最后9个月后，有父母监禁经历的子样本 考核具体而言，目标1将利用多层次逻辑回归分析和潜在的 生长曲线建模，以确定CT在降低风险方面的潜在差异疗效 有过父母教育经历的青少年妇女中， 监禁。在目标2中，将采用多层贝叶斯结构方程模型， 评估父母对CT作用机制的介导治疗效果 监禁。在目标3中，将对20名青少年进行定性访谈， 干预组的妇女探索她们父母被监禁的生活经历， 可能影响CT的有效性和可接受性，并收集他们的适应性建议。 拟议的多样性补充研究是家长补助金的自然延伸 同时为有前途的新研究者提供了一个新的机会， 预防研究侧重于有父母监禁经历的青少年， 接受来自经验丰富的研究人员组成的强大团队的指导。这种多样性补充 将帮助候选人获得干预研究，复杂的定量研究， 临床试验数据分析、定性研究和手稿准备。此外，数据 将为K01应用提供关于开发新的或适应性干预措施（例如 作为CT）的青少年与父母监禁的经验，与长期目标， 在更大的R01研究中测试其功效。这种多样性补充将大大有助于 候选人成为独立NIH研究员的轨迹。