Investigating the Cell Division Machinery

摘要 细胞分裂是一组复杂的、特别精心策划的事件，最终导致 姐妹染色单体分离成两个细胞。它依赖于大量的蛋白质复合体，蛋白质- 蛋白质相互作用和翻译后活动驱动的调节机制 修饰酶。托雷斯实验室使用多学科方法来研究这些酶 以及高保真地进行人类细胞分裂所必需的调控机制， 在癌症等疾病中，它们通常是不受调控的。这种动态的研究环境提供了 学生获得广泛的现代细胞和分子基础培训的独特机会 生物学。这一行政补充将允许一名有才华的本科生沉浸在 2023年暑假期间为期十周的全面研究和职业培训体验。 Torres实验室将提供一个动态、包容、协作和支持的环境，其中 学生将获得技术、操作和专业技能，为 生物医学生涯。该学生将对一组新的相关蛋白质进行研究，这些蛋白质可以定位 以微管为基础的结构，以及对其功能很重要的结构，包括有丝分裂纺锤体 组装，这属于最初的Mira项目的范围。学生将获得严格的 实验设计技能.数据分析的统计和定量技能.分析和关键 思维能力；口头和书面沟通能力；了解如何进行安全操作 和伦理研究。学生的研究经验将与接触到 与细胞周期和细胞骨架有关的细胞和分子生物学的广泛领域 专业技能的发展。这将包括学生出席和研究报告，在 托雷斯实验室会议，加州大学洛杉矶分校细胞骨架超级小组会议，加州大学洛杉矶分校本科生 研究研讨会、分子生物学研究所研究研讨会。此外，学生还将 接受PI和一名工作人员研究助理的一对一指导和动手培训 定期的。总而言之，这一以学生为中心的全面指导、研究培训和 职业发展计划将使学生能够成功地为生物医学职业生涯做准备。

SUMMARY Cell division is a complex and specifically orchestrated set of events that culminates in the equal segregation of sister chromatids into two cells. It relies on a multitude of protein complexes, protein- protein interactions, and regulatory mechanisms driven by the activities of posttranslational modification enzymes. The Torres lab uses multidisciplinary approaches to investigate the enzymes and regulatory mechanisms that are necessary to carry out human cell division with high fidelity, which are often dysregulated in diseases like cancer. This dynamic research environment provides students a unique opportunity to obtain broad foundational training in modern cell and molecular biology. This administrative supplement will allow one talented undergraduate student to immerse in a comprehensive research and career training experience for ten weeks during the summer of 2023. The Torres lab will provide a dynamic, inclusive, collaborative, and supportive environment, where the student will acquire technical, operational, and professional skills that will prepare them for a biomedical career. The student will carry out research on a novel set of related proteins that localize to microtubule-based structures and that are important for their function, including mitotic spindle assembly, which lies within the scope of the original MIRA project. The student will gain rigorous experimental design skills; statistical and quantitative skills for data analysis; analytical and critical thinking skills; oral and written communication skills; and an understanding of how to conduct safe and ethical research studies. The student’s research experience will be coupled with exposure to broad areas of cell and molecular biology related to the cell cycle and cytoskeleton and the development of professional skills. This will include student attendance and research presentations at Torres lab meetings, the UCLA cytoskeleton supergroup meetings, the UCLA undergraduate research symposium, and molecular biology institute research seminars. Additionally, the student will receive one-on-one mentoring and hands on training from the PI and a staff research associate on a regular basis. Together, this comprehensive student-centered mentoring, research training, and career development plan will enable the student to successfully prepare for a biomedical career.