Investigating the Cell Division Machinery

总结 细胞分裂是一个复杂的，特别是精心策划的一系列事件， 姐妹染色单体分离成两个细胞。它依赖于大量的蛋白质复合物，蛋白质- 蛋白质相互作用，以及由翻译后活动驱动的调节机制， 修饰酶托雷斯实验室使用多学科方法来研究酶 以及高保真地进行人类细胞分裂所必需的调节机制， 在癌症等疾病中经常失调。这种动态的研究环境提供了 学生一个独特的机会，获得广泛的基础培训，在现代细胞和分子 生物学这种行政补充将允许一个有才华的本科生沉浸在一个 在2023年夏季进行为期十周的综合研究和职业培训。 托雷斯实验室将提供一个充满活力、包容、协作和支持的环境， 学生将获得技术，操作和专业技能，这将为他们准备一个 生物医学事业学生将进行一组新的相关蛋白质的研究， 微管为基础的结构和重要的功能，包括有丝分裂纺锤体 组装，这是在原来的MIRA项目的范围内。学生将获得严格的 实验设计技能;数据分析的统计和定量技能;分析和批判 思维能力;口头和书面沟通能力;以及如何进行安全的理解 和伦理研究。学生的研究经验将与接触到 广泛的细胞和分子生物学领域，涉及细胞周期和细胞骨架， 发展专业技能。这将包括学生出勤率和研究报告， 托雷斯实验室会议，加州大学洛杉矶分校细胞骨架超群会议，加州大学洛杉矶分校本科生 研究研讨会和分子生物学研究所研究研讨会。此外，学生将 接受PI和员工研究助理的一对一指导和实践培训， 定期.总之，这种全面的以学生为中心的指导，研究培训， 职业发展计划将使学生成功地为生物医学职业做好准备。

SUMMARY Cell division is a complex and specifically orchestrated set of events that culminates in the equal segregation of sister chromatids into two cells. It relies on a multitude of protein complexes, protein- protein interactions, and regulatory mechanisms driven by the activities of posttranslational modification enzymes. The Torres lab uses multidisciplinary approaches to investigate the enzymes and regulatory mechanisms that are necessary to carry out human cell division with high fidelity, which are often dysregulated in diseases like cancer. This dynamic research environment provides students a unique opportunity to obtain broad foundational training in modern cell and molecular biology. This administrative supplement will allow one talented undergraduate student to immerse in a comprehensive research and career training experience for ten weeks during the summer of 2023. The Torres lab will provide a dynamic, inclusive, collaborative, and supportive environment, where the student will acquire technical, operational, and professional skills that will prepare them for a biomedical career. The student will carry out research on a novel set of related proteins that localize to microtubule-based structures and that are important for their function, including mitotic spindle assembly, which lies within the scope of the original MIRA project. The student will gain rigorous experimental design skills; statistical and quantitative skills for data analysis; analytical and critical thinking skills; oral and written communication skills; and an understanding of how to conduct safe and ethical research studies. The student’s research experience will be coupled with exposure to broad areas of cell and molecular biology related to the cell cycle and cytoskeleton and the development of professional skills. This will include student attendance and research presentations at Torres lab meetings, the UCLA cytoskeleton supergroup meetings, the UCLA undergraduate research symposium, and molecular biology institute research seminars. Additionally, the student will receive one-on-one mentoring and hands on training from the PI and a staff research associate on a regular basis. Together, this comprehensive student-centered mentoring, research training, and career development plan will enable the student to successfully prepare for a biomedical career.