Acquisition of confocal scan to upgrade existing fluorescence microscope

获取共焦扫描以升级现有荧光显微镜

基本信息

  • 批准号:
    10796239
  • 负责人:
  • 金额:
    $ 23.45万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2020
  • 资助国家:
    美国
  • 起止时间:
    2020-05-01 至 2025-04-30
  • 项目状态:
    未结题

项目摘要

Project Summary This proposal is for an equipment administrative supplement to an existing MIRA R35 supporting the PI’s research addressing the molecular mechanisms of the extracellular signal-regulated kinases 1 and 2 (ERK1/2) signal transmission as guided by scaffold proteins. This research program focuses on understanding the mechanisms by which key regulators, such as the scaffold protein Shoc2, modify ERK1/2 signaling. These studies decipher and determine the mechanisms by which endosomal sorting regulates the ubiquitin-driven remodeling of Shoc2 complexes and signaling and illuminate the key steps that segregate Shoc2 into distinct intracellular sorting pathways. Preliminary studies have already yielded new insights into the molecular details of how Shoc2-activated ERK1/2 signals promote early developmental stages. For this work, zebrafish is used as a vertebrate model to investigate the in vivo effect of Shoc2 gene editing on the early stages of development since they offer distinct advantages for studies of development, including their transparency, as well as external and rapid development. Outcomes from this work are expected to produce an ambitious and comprehensive mechanistic understanding of how Shoc2 is involved in determining the specificity of ERK1/2 signaling outcomes. As such, this work is laying the groundwork for future studies on developmental disorders that will contribute to the advancement of novel therapeutic strategies and biomarkers. This administrative supplement application to acquire a confocal scanning disk as an ‘add-on’ to an existing 3i Marianas microscope platform will foster ongoing experiments in this research program. The advanced scanning capacities will significantly improve the quality of the imaging analysis to examine the distribution of Shoc2 signaling complexes in cells and will dramatically enhance these studies to examine the role of Shoc2- mediated signals in embryonic development.
项目总结

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Emilia Galperin其他文献

Emilia Galperin的其他文献

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{{ truncateString('Emilia Galperin', 18)}}的其他基金

Mechanisms and Functions of Shoc2-Transduced Cellular Signals
Shoc2 转导的细胞信号的机制和功能
  • 批准号:
    10387097
  • 财政年份:
    2020
  • 资助金额:
    $ 23.45万
  • 项目类别:
Mechanisms and functions of Shoc2-transduced cellular signals
Shoc2 转导的细胞信号的机制和功能
  • 批准号:
    10395494
  • 财政年份:
    2020
  • 资助金额:
    $ 23.45万
  • 项目类别:
Mechanisms and functions of Shoc2-transduced cellular signals
Shoc2 转导的细胞信号的机制和功能
  • 批准号:
    10613880
  • 财政年份:
    2020
  • 资助金额:
    $ 23.45万
  • 项目类别:
Diversity Supplement - Deciphering the Molecular Mechanisms Underlying Active Scaffolding
多样性补充 - 破译活性支架背后的分子机制
  • 批准号:
    9249209
  • 财政年份:
    2015
  • 资助金额:
    $ 23.45万
  • 项目类别:
Deciphering the molecular mechanisms underlying active scaffolding
破译活性支架背后的分子机制
  • 批准号:
    9279178
  • 财政年份:
    2015
  • 资助金额:
    $ 23.45万
  • 项目类别:
ROLE OF SHOC2 PROTEIN IN SPATIO-TEMPORAL REGULATION OF ERK KINASE CASCADE
SHOC2 蛋白在 ERK 激酶级联时空调控中的作用
  • 批准号:
    8360579
  • 财政年份:
    2011
  • 资助金额:
    $ 23.45万
  • 项目类别:
Regulation of MAPK Activity by EGFR Endocytosis
EGFR 内吞作用对 MAPK 活性的调节
  • 批准号:
    8137875
  • 财政年份:
    2010
  • 资助金额:
    $ 23.45万
  • 项目类别:
Regulation of MAPK Activity by EGFR Endocytosis
EGFR 内吞作用对 MAPK 活性的调节
  • 批准号:
    8114450
  • 财政年份:
    2010
  • 资助金额:
    $ 23.45万
  • 项目类别:
Regulation of MAPK Activity by EGFR Endocytosis
EGFR 内吞作用对 MAPK 活性的调节
  • 批准号:
    8322198
  • 财政年份:
    2010
  • 资助金额:
    $ 23.45万
  • 项目类别:
Regulation of MAP Activity by EGFR Endocytosis
EGFR 内吞作用对 MAP 活性的调节
  • 批准号:
    7683858
  • 财政年份:
    2008
  • 资助金额:
    $ 23.45万
  • 项目类别:

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