Effect of Acamprosate on CNS hyperexcitability in alcoho

临床和临床前研究表明，酒精依赖的发展过程涉及高谷氨酸状态，这被认为是情绪放松导致渴望和复发的信号，以及神经毒性导致认知障碍和大脑灰质丢失。临床前数据表明，氨基己酸酯可能是一种有用的药物，可以针对在戒断反复发作期间形成的高谷氨酸状态。该方案的主要目的是使用随机对照试验，评估氨基己酸酯在戒断期间和戒断后早期对中枢谷氨酸/谷氨酰胺浓度的影响(由磁共振波谱确定)。此外，正在为二次分析获得探索性的生物学和临床措施。

Clinical as well as preclinical studies indicate that the process for developing alcohol dependence involves a hyperglutamatergic state, which is thought to be a signal for emotional deregulations leading to craving and relapse, as well as neurotoxicity leading to cognitive impairment and loss of brain grey matter in alcoholic patients. Preclinical data indicate that acamprosate might be a useful agent to target the hyperglutamatergic state that develops during recurring episodes of withdrawal The primary aim of the protocol is to evaluate, using a randomized controlled trial, the effects of acamprosate on central glutamate/glutamine concentrations (as determined by MR spectroscopy) during withdrawal and the early post withdrawal period. In addition, exploratory biological and clinical measures are being obtained for secondary analyses.