Clinical Studies Investigating Aggressive Behaviors And
调查攻击行为和
基本信息
- 批准号:7317742
- 负责人:
- 金额:--
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:
- 资助国家:美国
- 起止时间:至
- 项目状态:未结题
- 来源:
- 关键词:
项目摘要
Preliminary results from a double blind study, comparing the effects of fluoxetine with placebo in a carefully selected group of 67 perpetrators of domestic violence, show that both abstinence from alcohol and the administration of fluoxetine decrease the likelihood that perpetrators will be aggressive. During the past year accrual for the protocol has been completed and we are in the process of performing the data analysis. In this analysis we will be examining the effect of fluoxetine on aggression, alcohol consumption, mood, emotional expressions during interactions with their spouse/significant others, and response to emotional stimuli using functional MRI (fMRI). It is hoped that the results from this study will: 1) help us to better understand the interaction between alcohol and aggression, and 2) lead to new forms of treatment for alcohol dependent individuals who have a history of domestic violence.
一项双盲研究的初步结果显示,在一组精心挑选的67名家庭暴力施暴者中,氟西汀与安慰剂的效果相比,戒酒和氟西汀的使用都降低了施暴者的攻击性。在过去的一年中,方案的累积已经完成,我们正在进行数据分析。在这项分析中,我们将使用功能性MRI(fMRI)检查氟西汀对攻击性、饮酒、情绪、与配偶/重要他人互动时的情绪表达以及对情绪刺激的反应的影响。希望这项研究的结果将:1)帮助我们更好地了解酒精和攻击之间的相互作用,2)为有家庭暴力史的酒精依赖者提供新的治疗形式。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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David T George其他文献
The CRF1 Antagonist Verucerfont in Anxious Alcohol-Dependent Women: Translation of Neuroendocrine, But not of Anti-Craving Effects
焦虑型酒精依赖女性中的 CRF1 拮抗剂 Verucerfont:神经内分泌的翻译,但不是抗渴望效应的翻译
- DOI:
10.1038/npp.2016.61 - 发表时间:
2016-04-25 - 期刊:
- 影响因子:7.100
- 作者:
Melanie L Schwandt;Carlos R Cortes;Laura E Kwako;David T George;Reza Momenan;Rajita Sinha;Dimitri E Grigoriadis;Emilio Merlo Pich;Lorenzo Leggio;Markus Heilig - 通讯作者:
Markus Heilig
David T George的其他文献
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{{ truncateString('David T George', 18)}}的其他基金
Clinical trial of SR141716, Rimonabant, to reduce volunt
SR141716、利莫那班的临床试验,以减少自愿
- 批准号:
6983095 - 财政年份:
- 资助金额:
-- - 项目类别:
Assessment,Treatment, and Pharmacological Interventions in Alcoholic Patients
酗酒患者的评估、治疗和药理学干预
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8156730 - 财政年份:
- 资助金额:
-- - 项目类别:
YOHIMBINE CHALLENGE TO STUDY NORADRENERGIC FUNCTION IN INDIVIDUALS
育亨宾挑战研究个体去甲肾上腺素能功能
- 批准号:
6097574 - 财政年份:
- 资助金额:
-- - 项目类别:
NK1 receptor antagonism for treatment of alcohol-dependent patients
NK1受体拮抗剂治疗酒精依赖患者
- 批准号:
7732104 - 财政年份:
- 资助金额:
-- - 项目类别:
Clinical Assessment and Treatment Evaluation of Alcohol Dependent Patients
酒精依赖患者的临床评估和治疗评价
- 批准号:
7963833 - 财政年份:
- 资助金额:
-- - 项目类别:
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