Genetics of Chronic Kidney Disease

慢性肾脏疾病（CKD）困扰着11%的美国成年人口。CKD的易感性各不相同 这表明遗传因素的作用。了解CKD的遗传预测因子可能会导致 采取更好的方法，查明和治疗有风险的个人，以防止艾滋病毒/艾滋病发病率和流行率上升 终末期肾病 动脉病遗传流行病学网络（GENOA）进行了全基因组连锁， 关联研究，以确定影响血压和脑动脉，心脏， 和高血压的外周血管并发症。拟议中的调查将扩大这些努力 通过在以前特征明确的欧洲白人和非洲人中确定CKD的遗传预测因子， 有两个或更多高血压成员的美洲兄弟姐妹。我们建议确定CKD的遗传预测因子 在这些种族多样的高风险群体中，通过实现以下具体目标： 目的1：确定动脉硬化的传统或新风险因素（已通过 GENOA）预测1000名欧洲白人和1000名非洲裔美国人的肾小球滤过率或蛋白尿 兄妹 目的2：确定是否在>250个高血压候选基因的双等位基因多态性或其 脑动脉、心脏和外周血管并发症（已通过 GENOA）预测1000名欧洲白人和1000名非洲裔美国人的肾小球滤过率或蛋白尿 兄妹 目的3：确定跨越基因组的387个高度多态性串联重复序列标记位点中是否有任何一个 （已经通过GENOA测量）与影响肾小球滤过率或白蛋白尿的基因有关， 超过1000对欧洲白人和1000对非洲裔美国人的兄弟姐妹。

Chronic kidney disease (CKD) afflicts 11% of the adult US population. Susceptibility to CKD varies considerably, suggesting a role for genetic factors. Knowledge of genetic predictors of CKD may lead to better methods of identifying and treating individuals at risk to prevent the rising incidence and prevalence of endstage renal disease. The Genetic Epidemiology Network of Arteriopathy (GENOA) has conducted genomewide linkage and association studies to identify genes influencing blood pressure and the arteriosclerotic cerebral, cardiac, and peripheral vascular complications of hypertension. The proposed investigation will extend those efforts by identifying genetic predictors of CKD in previously well-characterized European-white and African- American sibships with 2 or more hypertensive members. We propose to identify genetic predictors of CKD in these ethnically diverse, high-risk cohorts by accomplishing the following specific aims: Aim 1: Determine whether conventional or novel risk factors for arteriosclerosis (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000 African-American siblings. Aim 2: Determine whether diallelic polymorphisms in >250 candidate genes for hypertension or its arteriosclerotic cerebral, cardiac, and peripheral vascular vascular complications (already measured by GENOA) predict glomerular filtration rate or albuminuria in 1000 European-white and 1000African-American siblings. Aim 3: Determine whether any of 387 highly polymorphic tandem repeat marker loci spanning the genome (already measured by GENOA) are linked to genes influencing glomerular filtration rate or albuminuria in more than 1000 European-white and 1000 African-Americansibling pairs.