The Effect of Age on Neuromorphology and its Cognitive Consequences

年龄对神经形态的影响及其认知后果

• 批准号: 7617224
• 负责人: ADAM M BRICKMAN
• 金额: $ 15.6万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-15 至 2012-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7617224
• 关键词: Accounting; Address; African American; Age; Aging; Alzheimer' s Disease; Anterior; Attenuated; Blood Vessels; Brain; Brain region; Caucasians; Caucasoid Race; Clinical; Cognition; Cognitive; Cognitive aging; Cohort Studies; Communities; Data; Dementia; Development; Diabetes Mellitus; Diffuse; Elderly; Epidemiologic Methods; Epidemiologic Studies; Epidemiology; Ethnic Origin; Ethnic group; Etiology; Funding; Goals; Gray unit of radiation dose; Height; Hispanics; Hyperlipidemia; Hypertension; Individual; Individual Differences; Instruction; Insulin Resistance; Investigation; Knowledge; Longitudinal Studies; Magnetic Resonance Imaging; Measurement; Measures; Mediating; Mediator of activation protein; Memory; Mentored Patient-Oriented Research Career Development Award; Mentors; Methodology; Modeling; Neurobiology; Neurologic; Neuropsychological Tests; Obesity; Pattern; Performance; Population; Population Study; Recruitment Activity; Research; Research Personnel; Risk; Risk Factors; Sampling; System; Techniques; Testing; Time; Training; United States; Universities; Washington; age effect; age related; base; brain volume; career; cerebral atrophy; cerebrovascular; cognitive function; cohort; design; ethnic minority population; executive function; experience; hypercholesterolemia; neurobiological mechanism; neuroimaging; normal aging; novel; patient oriented research; performance tests; population based; programs; research and development; responsible research conduct; skill acquisition; skills; white matter

DESCRIPTION (provided by applicant): This is an application for a Mentored Patient-Oriented Research Development Award (K23). The goal of the proposed project is to provide the Applicant with advanced skills needed to establish an independent program of research in cognitive aging using neuroimaging and epidemiological methodologies. The Applicant proposes a comprehensive training plan, combining didactic instruction with established researchers; formal coursework; participation in ongoing seminars at Columbia University; and applied training experiences with individual advisors. Specific training goals include advanced knowledge and skill acquisition in the neurobiological mechanisms of cognitive aging; potential mediators and moderators of cognitive aging, including cerebrovascular risk factors and cross-cultural issues; design, implementation, and statistical analysis of epidemiological studies; principles of magnetic resonance imaging (MRI) and advanced neuromorphometric analysis; and the responsible conduct of research. The training plan will be executed in coordination with a proposed study that utilizes data from the Washington Heights Inwood Columbia Aging Project (WHICAP), an ongoing NIA funded study (P01AG007232) of risk factors for dementia in a multiethnic population of older adults residing in northern Manhattan. Although the main goal of WHICAP is to elucidate risk factors of Alzheimer's disease, it does not explicitly characterize neuromorphology or cognition in individuals who do not develop dementia. The proposed study will address the determinants of neuromorphology and related cognitive profiles among approximately 700 older individuals in the WHICAP cohort with "normal" age-related cognitive function. The project will examine the association between chronological age and several measures of neuromorphology, including regional volumes, white matter hyperintensity burden, and a new multivariate approach for the characterization of age-associated patterns of gray and white matter. These measures will be related to baseline performance on neuropsychological tests and change in cognition following an 18-month period. A secondary goal will be to examine the mediating effect of cerebrovascular risk factors (i.e., hypertension, insulin resistance, obesity, and hypercholesterolemia) and ethnic group differences on neuromorphology. The proposed project aims will therefore elucidate neurobiological changes associated with aging and will serve as a bridge for the Applicant to establish an independent investigator career in conducting large- scale neuromorphometry studies on clinical populations.

描述（由申请人提供）：这是一个指导患者为导向的研究开发奖（K23）的申请。该项目的目标是为申请人提供先进的技能，以建立一个独立的研究计划，在认知老化使用神经影像学和流行病学方法。申请人提出了一个全面的培训计划，结合教学指导与既定的研究人员;正式的课程;在哥伦比亚大学正在进行的研讨会的参与;和应用与个人顾问的培训经验。具体的培训目标包括认知老化的神经生物学机制方面的先进知识和技能获取;认知老化的潜在介导者和调节者，包括脑血管风险因素和跨文化问题;流行病学研究的设计，实施和统计分析;磁共振成像（MRI）和高级神经形态测量分析的原则;以及负责任的研究行为。该培训计划将与一项利用华盛顿高地Inwood哥伦比亚老龄化项目（WHICAP）数据的拟议研究协调执行，该项目是一项正在进行的NIA资助的研究（P01 AG 007232），研究居住在曼哈顿北方的多种族老年人人群中痴呆症的风险因素。虽然WHICAP的主要目标是阐明阿尔茨海默病的危险因素，但它并没有明确描述没有发展成痴呆症的个体的神经形态学或认知。这项拟议的研究将讨论在WHICAP队列中约700名具有“正常”年龄相关认知功能的老年人中神经形态学和相关认知特征的决定因素。该项目将研究实足年龄和神经形态学的几个措施，包括区域体积，白色物质高密度负荷，和一个新的多变量的方法来表征与年龄相关的模式的灰色和白色物质之间的关联。这些指标将与神经心理学测试的基线表现和18个月后的认知变化相关。第二个目标是检查脑血管危险因素的介导作用（即，高血压、胰岛素抵抗、肥胖和高胆固醇血症）和种族群体在神经形态学上的差异。因此，拟议的项目目标将阐明神经生物学变化 与衰老相关，并将作为申请人建立独立研究者职业生涯的桥梁，在临床人群中进行大规模神经形态计量学研究。