MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS

MMP-9 作为动脉粥样硬化形成中的促炎调节剂

• 批准号: 7729741
• 负责人: Elaine W Raines
• 金额: $ 56.37万
• 依托单位: UNIVERSITY OF WASHINGTON
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7729741
• 关键词: Animal Model; Apolipoprotein E; Arterial Fatty Streak; Atherosclerosis; Binding; Cell Surface Receptors; Cells; Clinical; Coagulation Process; Deposition; Devices; Disease Progression; Drug Formulations; Enzymes; Experimental Models; Extracellular Matrix; Fibrin; Frequencies; Funding; Gelatinase B; Grant; Heterogeneity; Human; Immune response; In Vitro; Inflammation; Inflammatory; Inflammatory Response; Integrins; Lesion; Link; Mediating; Methodology; Modeling; Molecular; Mus; Myocardial Infarction; Pathway interactions; Peptide Hydrolases; Plasminogen; Play; Process; Proteomics; Regulation; Resolution; Retroviral Vector; Role; Rupture; Shoulder; Signal Transduction; Site; Stroke; TFPI; Testing; Thromboplastin; Time; atherogenesis; chemokine; human disease; hypercholesterolemia; in vivo; macrophage; mouse model; novel; prevent

The goa/ of this project is to test the hypothesis that MMP-9 leads to proteolytic cleavage of key regulators of coagulation and inflammation that promote plaque rupture and to compare proteolytic targets in ruptured human and mouse lesions.

该项目的目的是验证MMP-9导致凝血和炎症关键调节因子的蛋白水解裂解的假设，从而促进斑块破裂，并比较破裂的人和小鼠病变中的蛋白水解靶点。