MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
批准号:
7923973
负责人:
Elaine W Raines
金额:
$58.06万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2005
资助国家:
美国
项目状态:
已结题
起止时间:
2005-09-01 至 2012-08-31
关键词:
Animal ModelApolipoprotein EArterial Fatty StreakAtherosclerosisBindingCell Surface ReceptorsCellsClinicalCoagulation ProcessDepositionDevicesDisease ProgressionDrug FormulationsEnzymesExperimental ModelsExtracellular MatrixFibrinFrequenciesFundingGelatinase BGrantHeterogeneityHumanImmune responseIn VitroInflammationInflammatoryInflammatory ResponseIntegrinsLesionLinkMediatingMethodologyModelingMolecularMusMyocardial InfarctionPathway interactionsPeptide HydrolasesPlasminogenPlayProcessProteomicsRegulationResolutionRetroviral VectorRoleRuptureShoulderSignal TransductionSiteStrokeTFPITestingThromboplastinTimeatherogenesischemokinehuman diseasehypercholesterolemiain vivomacrophagemouse modelnovelprevent
中文摘要
该项目的目的是验证这一假设,即基质金属蛋白酶-9导致促进斑块破裂的凝血和炎症关键调节因子的蛋白分解,并比较人类和小鼠破裂损伤中的蛋白分解靶点。
英文摘要
The goa/ of this project is to test the hypothesis that MMP-9 leads to proteolytic cleavage of key regulators of coagulation and inflammation that promote plaque rupture and to compare proteolytic targets in ruptured human and mouse lesions.
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会议论文
Proteolytic control of local inflammatory macrophage proliferation
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批准号:9038435
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项目类别:
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资助金额:$49.42万
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财政年份:2015
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负责人:Elaine W Raines
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依托单位:
Proteolytic control of local inflammatory macrophage proliferation
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批准号:8892773
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项目类别:
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资助金额:$49.42万
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财政年份:2015
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负责人:Elaine W Raines
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依托单位:
Cloaking Key MMP-9 Substrates to Probe the role of Their Cleavage in Plaque Ruptu
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批准号:8055931
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项目类别:
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资助金额:$27.3万
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财政年份:2010
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负责人:Elaine W Raines
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依托单位:
Cloaking Key MMP-9 Substrates to Probe the role of Their Cleavage in Plaque Ruptu
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批准号:7872152
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项目类别:
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资助金额:$15.6万
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财政年份:2010
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负责人:Elaine W Raines
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依托单位:
Core--Mouse Atherosclerosis and Analysis
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批准号:7140041
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项目类别:
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资助金额:$48.31万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
MACROPHAGE CELL-SURFACE PROTEOLYSIS IN ATHEROGENESIS
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批准号:6861526
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项目类别:
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资助金额:$37.9万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
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批准号:7729741
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项目类别:
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资助金额:$56.37万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
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批准号:7074635
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项目类别:
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资助金额:$37.01万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
Macrophage Cell-Surface Proteolysis and Inflammation
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批准号:7140029
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项目类别:
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资助金额:$24.16万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
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批准号:7236746
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项目类别:
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资助金额:$35.94万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
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批准号:7431723
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项目类别:
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资助金额:$35.94万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
MMP-9 AS A PROINFLAMMATORY REGULATOR IN ATHEROGENESIS
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批准号:6964780
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项目类别:
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资助金额:$37.9万
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财政年份:2005
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负责人:Elaine W Raines
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依托单位:
COORDINATE REGULATION OF SMOOTH MUSCLE BY PDGF & MATRIX
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批准号:6654171
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项目类别:
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资助金额:$26.64万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
ADAM-mediated Shedding in Endothelial Inflammatory Responses
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批准号:8650298
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项目类别:
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资助金额:$43.86万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
ADAM-mediated Shedding in Endothelial Inflammatory Responses
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批准号:8449106
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项目类别:
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资助金额:$42.61万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
CORE--TISSUE/CELL CULTURE
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批准号:6654170
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项目类别:
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资助金额:$26.64万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
ADAM17 - Mediated Shedding in Endothelial Inflammatory Responses
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批准号:7466979
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项目类别:
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资助金额:$43.49万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
Role of ADAMs in Endothelial Inflammatory Response
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批准号:6877719
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项目类别:
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资助金额:$34.11万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
ADAM-mediated Shedding in Endothelial Inflammatory Responses
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批准号:8321151
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项目类别:
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资助金额:$44.61万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
Role of ADAMs in Endothelial Inflammatory Response
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批准号:6623833
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项目类别:
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资助金额:$30.32万
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财政年份:2002
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负责人:Elaine W Raines
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依托单位:
海外基金