FEASIBILITY STUDY OF DETECTION OF CERVICAL DYSPLYSIA

宫颈发育不良检测的可行性研究

• 批准号: 8364146
• 负责人: Dax Fu
• 金额: $ 0.74万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364146
• 关键词: Biomedical Research; Cervical; Cervix Uteri; Colposcopy; Detection; Dysplasia; Feasibility Studies; Fluorescence; Funding; Generations; Grant; Image; Lasers; Malignant neoplasm of cervix uteri; Measures; National Center for Research Resources; Principal Investigator; Research; Research Infrastructure; Resources; Site; Source; Spectrum Analysis; Squamous intraepithelial lesion; System; Tissues; United States National Institutes of Health; absorption; cancer diagnosis; cost; in vivo; instrument; interest

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are using Quantitative Spectroscopy (QS) to detect dysplasia in the uterine cervix in vivo. We have developed the Quantitative Spectroscopy Imaging (QSI) system to collect reflectance and fluorescence spectra in vivo from the site of interest. Measured scattering, absorption, and fluorescence from each tissue site are used to identify high-grade squamous intraepithelial lesions (HSIL) in the cervix. We have demonstrated that quantitative spectroscopy has much better accuracy in comparison to traditional colposcopy for cervical cancer diagnosis using our previous generation tri-modal spectroscopy instrument.

该子项目是利用资源的许多研究子项目之一 由NIH/NCRR资助的中心赠款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其他NIH来源。 列出的子项目总成本可能 表示子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们正在使用定量光谱（QS）来检测子宫颈的体内发育不良。我们已经开发了定量光谱成像（QSI）系统，以收集在体内的反射光谱和荧光光谱从感兴趣的网站。从每个组织部位测量的散射、吸收和荧光用于识别宫颈中的高度鳞状上皮内病变（HSIL）。我们已经证明，定量光谱具有更好的准确性相比，传统的阴道镜宫颈癌诊断使用我们的上一代三模式光谱仪器。