SIDE-VIEWING RAMAN OPTICAL FIBER PROBE FOR BIOMEDICAL SPECTROSCOPY

用于生物医学光谱学的侧视拉曼光纤探头

• 批准号: 8364148
• 负责人: NARAHARA CHARI DINGARI
• 金额: $ 2.97万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364148
• 关键词: Biomedical Research; Breast; Breast Microcalcification; Calcium; Clinical Research; Core Biopsy; Deposition; Devices; Fiber; Fiber Optics; Funding; Grant; Lasers; Light; Mammary Gland Parenchyma; Mammography; Minerals; National Center for Research Resources; Needle biopsy procedure; Needles; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Resources; Salts; Screening procedure; Side; Signal Transduction; Source; Spectrum Analysis; Time; United States National Institutes of Health; clinically significant; cost; design; in vivo; optical fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We are investigating the usage of Raman spectroscopy to guide stereotactic core needle biopsies of the breast for suspicious microcalcifications discovered at screening mammography. Microcalcifications are deposits of calcium mineral salts within breast tissue that mammographically localize the most clinically significant abnormality and are, therefore, a target for subsequent needle biopsy. Raman spectroscopy is exquisitely sensitive to the presence of calcium-containing minerals, and thus can be used to detect and localize microcalcifications in the breast. This can be done in vivo, in real-time, in a non-destructive manner, via optical fiber probes that are compatible with existing needle biopsy devices. The side-viewing Raman fiber optic probe provides capability of utilizing the excitation light from Raman source and delivering to and collecting the light from the breast tissue while the probe inserted into needle device. The probe is designed to fit into 9 gauge needle device most commonly used during stereotactic core needle biopsies. Similar to the front-viewing Raman probe that has been successfully used in the in vivo and ex vivo clinical studies, the side-viewing probe incorporate excitation and emission filters with coatings to suppress fiber background and enable efficient extraction of the Raman signal.

该子项目是利用资源的众多研究子项目之一 由 NIH/NCRR 资助的中心拨款提供。子项目的主要支持 并且子项目的主要研究者可能是由其他来源提供的， 包括其他 NIH 来源。 子项目可能列出的总成本 代表子项目使用的中心基础设施的估计数量， NCRR 赠款不直接向子项目或子项目工作人员提供资金。 我们正在研究使用拉曼光谱来指导乳房立体定向芯针活检，以发现筛查乳房 X 光检查中发现的可疑微钙化。微钙化是乳腺组织内钙矿物盐的沉积物，通过乳房 X 线摄影定位临床上最显着的异常，因此是后续针吸活检的目标。 拉曼光谱对含钙矿物质的存在非常敏感，因此可用于检测和定位乳房中的微钙化。这可以通过与现有针吸活检设备兼容的光纤探针以非破坏性的方式在体内实时完成。侧视拉曼光纤探头能够利用来自拉曼源的激发光，并在探头插入针装置时将光传送到乳腺组织并收集来自乳腺组织的光。该探头设计用于安装在立体定向核心针活检过程中最常用的 9 号针装置。与已成功用于体内和离体临床研究的前视拉曼探头类似，侧视探头将激发和发射滤光片与涂层结合在一起，以抑制纤维背景并能够有效提取拉曼信号。