CLINICAL RAMAN INSTRUMENT

临床拉曼仪器

• 批准号: 8364149
• 负责人: NARAHARA CHARI DINGARI
• 金额: $ 2.97万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-06-01 至 2012-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8364149
• 关键词: Atherosclerosis; Biological; Biomedical Research; Clinical; Clinical Research; Diagnosis; Diagnostic Procedure; Fingerprint; Fostering; Funding; Grant; Laboratories; Lasers; Microscopy; National Center for Research Resources; Optics; Principal Investigator; Raman Spectrum Analysis; Research; Research Infrastructure; Research Personnel; Resources; Source; Spectrum Analysis; System; Tissues; Translational Research; United States National Institutes of Health; base; cost; in vivo; instrument; malignant breast neoplasm; optical fiber

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have investigated the usage of Raman spectroscopy to diagnose atherosclerosis and breast cancer. Over the years, we have successfully conducted several in vivo and ex vivo clinical studies. We were able to minimize our microscopy-based laboratory system into a clinical Raman system utilizing a Raman fiber optical probe. Currently, we are developing a mini-Raman clinical instrument that will be available for users outside of the LBRC. The purposes of this project are to foster clinical translational research in optical spectroscopy; and to familiarize young/new investigators with the methods of diagnostic spectroscopy. The LBRC will provide Raman spectroscopy instrument capable of collecting Raman spectra from biological tissues over the fingerprint range (600-1800cm-1).

这个子项目是许多利用资源的研究子项目之一 由NIH/NCRR资助的中心拨款提供。子项目的主要支持 而子项目的主要调查员可能是由其他来源提供的， 包括其它NIH来源。 列出的子项目总成本可能 代表子项目使用的中心基础设施的估计数量， 而不是由NCRR赠款提供给子项目或子项目工作人员的直接资金。 我们已经研究了拉曼光谱的使用，以诊断动脉粥样硬化和乳腺癌。多年来，我们成功进行了多项体内和体外临床研究。我们能够利用拉曼光纤探针将基于显微镜的实验室系统最小化为临床拉曼系统。目前，我们正在开发一种微型拉曼临床仪器，将提供给LBRC以外的用户。该项目的目的是促进光谱学的临床转化研究;并使年轻/新的研究人员熟悉诊断光谱学的方法。LBRC将提供拉曼光谱仪器，能够收集生物组织在指纹范围（600- 1800 cm-1）内的拉曼光谱。