CLINICAL RAMAN INSTRUMENT

这个子项目是利用资源的许多研究子项目之一。 由NIH/NCRR资助的中心拨款提供。对子项目的主要支持 子项目的首席调查员可能是由其他来源提供的， 包括美国国立卫生研究院的其他来源。为子项目列出的总成本可能 表示该子项目使用的中心基础设施的估计数量， 不是由NCRR赠款提供给次级项目或次级项目工作人员的直接资金。 我们研究了拉曼光谱技术在动脉粥样硬化和乳腺癌诊断中的应用。多年来，我们成功地进行了多项体内和体外临床研究。我们能够利用拉曼光纤探头将我们基于显微镜的实验室系统最小化为临床拉曼系统。目前，我们正在开发一种迷你拉曼临床仪器，将向LBRC以外的用户提供。这个项目的目的是促进光学光谱学的临床转化研究；并使年轻/新的研究人员熟悉诊断光谱学的方法。LBRC将提供拉曼光谱仪器，能够在指纹范围(600-1800厘米-1)内收集生物组织的拉曼光谱。

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. Primary support for the subproject and the subproject's principal investigator may have been provided by other sources, including other NIH sources. The Total Cost listed for the subproject likely represents the estimated amount of Center infrastructure utilized by the subproject, not direct funding provided by the NCRR grant to the subproject or subproject staff. We have investigated the usage of Raman spectroscopy to diagnose atherosclerosis and breast cancer. Over the years, we have successfully conducted several in vivo and ex vivo clinical studies. We were able to minimize our microscopy-based laboratory system into a clinical Raman system utilizing a Raman fiber optical probe. Currently, we are developing a mini-Raman clinical instrument that will be available for users outside of the LBRC. The purposes of this project are to foster clinical translational research in optical spectroscopy; and to familiarize young/new investigators with the methods of diagnostic spectroscopy. The LBRC will provide Raman spectroscopy instrument capable of collecting Raman spectra from biological tissues over the fingerprint range (600-1800cm-1).