High Performance Computing for Biomedical Research

描述（由申请人提供）：国家生物医学超级计算资源（NRBSC）将基于高性能计算和通信进行并实现领先的生物医学研究，培训和传播。为了实现这一目标，我们将：-在核心和合作研究中发挥主导作用，重点是：- 基于蒙特卡罗算法的空间真实细胞建模-基于可极化力场和混合量子力学/分子力学算法的分子建模-共享可视化，操纵，和分析大量的体积数据集-通过以下方式促进国家生物医学研究界的多学科生物学和计算专业知识：- 一个经过验证的优秀培训计划，专注于我们的主要研究领域-国家的最先进的网络网关NRBSC和主要的软件包正在开发中的NRBSC（MCell，DReAMM，PSC-VB，PSCIO）-一种最先进的开放式软件许可和分发机制，专为复杂的科学代码和在学术环境中工作的开发人员的需求量身定制-创新的集成教育工具，专为广泛的受众设计，基于最先进的Web开发工具NRBSC由匹兹堡超级计算中心托管，学术超级计算的领先国家资源。因此，NRBSC是唯一有资格通过高性能计算来推动国家在生物医学研究方面的进步。

DESCRIPTION (provided by applicant): The National Resource for Biomedical Supercomputing (NRBSC) will perform and enable leading edge biomedical research, training, and dissemination based on high performance computing and communications. To achieve this goal we will: -Play a leading role in Core and Collaborative research focused on: -spatially realistic cell modeling based on Monte Carlo algorithms -molecular modeling based on polarizable force fields and hybrid quantum mechanical/molecular mechanical algorithms -shared visualization, manipulation, and analysis of massive volumetric datasets -Promote multidisciplinary biological and computational expertise in the nation's biomedical research community through: -a proven outstanding training program focused on our primary research areas -state-of-the-art web gateways to the NRBSC and primary software packages under development at the NRBSC (MCell, DReAMM, PSC-VB, DYNAMO) -a state-of-the-art open software licensing and distribution mechanism tailored to the needs of complex scientific codes and developers working in an academic setting -innovative, integrated educational tools designed for broad audiences and based on state-of-the-art web development tools The NRBSC is hosted by the Pittsburgh Supercomputing Center, a leading national resource for academic supercomputing. The NRBSC thus is uniquely qualified to advance the nation's progress in biomedical research through high performance computing.