Neurexin and Neuroligin: A Code for Synaptic Development

Neurexin 和 Neuroligin：突触发育的密码

• 批准号: nhmrc : 1008125
• 负责人: A/Pr Bruno Van Swinderen
• 金额: $ 23.31万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2011
• 资助国家: 澳大利亚
• 起止时间: 2011-01-01 至 2013-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/neurexin-neuroligin-code-synaptic-development/109282
• 关键词: Neurexin; Neuroligin; Code; Synaptic; Development

As soon as we are born, we interpret our world through our senses, learn new information and lay down memory. These processes require molecules that connect neurons together. Mutations in genes encoding these molecules result in incorrect wiring of the brain and lead to mental disorders such as autism and schizophrenia. Using simple insect models, our project aims to unravel the fundamental mechanisms of how these molecules function in the brain and how their interaction controls behaviour.

我们一出生，就通过感官解释世界，学习新信息并留下记忆。这些过程需要将神经元连接在一起的分子。编码这些分子的基因突变会导致大脑接线错误，并导致自闭症和精神分裂症等精神疾病。使用简单的昆虫模型，我们的项目旨在揭示这些分子如何在大脑中发挥作用以及它们的相互作用如何控制行为的基本机制。