Discovering deep sleep genes and determining their roles for preserving cognitive functions

发现深度睡眠基因并确定它们在保护认知功能中的作用

• 批准号: nhmrc : 1065713
• 负责人: A/Pr Bruno Van Swinderen
• 金额: $ 32.33万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/discovering-deep-sleep-cognitive-functions/455191
• 关键词: Discovering; deep; sleep; genes; determining

Our mental well-being is largely tied to our sleep quality, and most cognitive disorders are also associated with poor sleep processes. Yet, we still do not know how sleep quality safeguards cognitive function. We will uncover genes that play a restorative role during deep sleep, and determine how genetic control of these deep sleep genes modulates selective attention in an animal model. Our results will suggest novel therapies for treating sleep disorders and associated diseases of the brain.

我们的心理健康很大程度上与睡眠质量有关，大多数认知障碍也与睡眠过程不佳有关。然而，我们仍然不知道睡眠质量如何保障认知功能。我们将发现在深度睡眠期间发挥恢复作用的基因，并确定这些深度睡眠基因的遗传控制如何调节动物模型中的选择性注意力。我们的研究结果将为治疗睡眠障碍和相关大脑疾病提出新的疗法。