Animal Research and Immunology Core

五大湖生物防御和新发传染病区域中心的使命 动物研究与免疫学中心（ARIC）是为动物免疫学研究提供专业研究服务的机构。 针对NIAID A、B和C类因子的疫苗、诊断和治疗的开发，以及 在紧急情况下支持GLRCE，组织湿实验室基础设施和生物防御 RCE网络的专业知识。在上一个供资期间，叙利亚红新月会在 芝加哥大学和霍华德Taylor里基茨实验室（位于阿贡国家 实验室）、最先进的BSL-2/3和ABSL-2/3研究空间，支持工作和科学培训 根据NIAID A-C类药剂的标准化、安全实验室操作规程。获得的GLRCE ARIC CDC注册和认证，以维持蓬勃发展的精选代理计划，该计划已经涵盖 几种不同的A-C试剂：Y. pestis（pestis）、B.炭疽菌（anthracis），R.伤寒R.立克次氏体（洛基 山斑热），R. conori（地中海斑点热）和MRSA（耐药链球菌）。 aureus)具有良好的抗菌活性。 ARIC使用基于Web的门户网站（www.glrce.org）向用户宣传和提供研究服务 在研究界，包括动物模型、疫苗和免疫 应答研究、攻毒实验、对免疫接种的免疫应答表征或 感染、免疫试剂和测定的制备、药物抗性和治疗研究， 体外和体内微生物复制的测量，以及动物病理学研究。为下一 在资助期内，GLRCE ARIC计划提供标准化、高质量的动物模型系统，以 开发和维持有氧系统，开发免疫测试、试剂和相关的 开发和维持小分子抑制剂在体外的抗生素活性测试 NIAID A-C类药剂。

The mission of the Great Lakes Regional Center for Biodefense and Emerging Infectious Diseases (GLRCE) Animal Research and Immunology Core (ARIC) is to provide professional research services in support of the development of vaccines, diagnostics and therapeutics against NIAID Category A, B and C agents and to support GLRCE under emergency situations, marshalling wet laboratory infrastructures and biodefense expertise for the RCE network. During the previous funding period, SARC established infrastructures at the University of Chicago and at the Howard Taylor Ricketts Laboratory (located at Argonne National Laboratory), state-of-the-art BSL-2/3 and ABSL-2/3 research space, enabling work and scientific training under standardized, safe laboratory practices on NIAID Category A-C agents. The GLRCE ARIC acquired CDC registration and certification to sustain a flourishing select agent program that already encompasses several different A-C agents: Y. pestis (plague), B. anthracis (anthrax), R. typhi (typhus), R. rickettsii (Rocky Mountain Spotted Fever), R. conori (Mediterranean Spotted Fever), and MRSA (drug resistant S. aureus). ARIC uses a web-based portal (www.glrce.org) to advertise and make research services available to users in the research community, which includes virulence studies in animal models, vaccine and immune responses studies, challenge experiments, characterization of immune responses to immunization or infection, preparation of immunological reagents and assays, drug resistance and therapy studies, measurements of microbial replication in vitro and in vivo, and animal pathology studies. For the next funding period, GLRCE ARIC proposes to provide standardized, high quality animal model systems, to develop and sustain aerobiology systems, to develop immunological tests, reagents and correlates of immunity, and to develop and sustain in vitro testing of small molecule inhibitors for antibiotic activity on NIAID category A-C agents.