Stanford/Salk MoTrPAC Site for Genomes, Epigenomes and Transcriptomes

斯坦福/索尔克 MoTrPAC 基因组、表观基因组和转录组网站

基本信息

  • 批准号:
    9518558
  • 负责人:
  • 金额:
    $ 15.8万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2016
  • 资助国家:
    美国
  • 起止时间:
    2016-12-13 至 2017-11-30
  • 项目状态:
    已结题

项目摘要

Lack of physical activity is central to numerous health problems. Despite this, we have limited understanding of the molecular components which confer the benefit of physical activity and their diverse impacts across tissues with respect to age, sex, genetics, environment and other objective physiologic, morphometric, and metabolic measures. Identifying these molecular signatures offers to provide new opportunities for treatment and therapeutics. The goal of the Molecular Transducers of Physical Activity in Humans Consortium (MoTrPAC) is to assemble a comprehensive map of the molecular changes that occur in response to physical activity and, when possible, relate these changes to the benefits of physical activity. This map will be greatly facilitated by the application of –omics technologies to identify exercise-responsive genes and to relate their benefits across multiple tissues and contexts. We propose to aid in the construction of this map as the Stanford/Salk MoTrPAC Genome, Epigenome and Transcriptome (GET) Chemical Analysis Center. We will leverage our production and analysis experience to engage in MoTrPAC study design, enable the production of high quality and low cost genomes, epigenomes and transcriptomes and facilitate and engage in bioinformatics analysis with the MoTrPAC Bioinformatics Center. Key activities will include coordination and collaboration with all the MoTrPAC sites from tissue management to data delivery. Through these activities we will sequence 3000 genomes and at least 40000 epigenomes and 40000 transcriptomes for samples collected at MoTrPAC animal and human study sites. Our site will engage in multiple levels of quality control from tissue collection to sequence mapping. Generated data in common data formats will be immediately available to MoTrPAC investigators and the Bioinformatics Center through the Google Cloud. In addition, as part of our proposed site, and in coordination with both the MoTrPAC Steering Committee and investigators, we will leverage our expertise in both studies of exosomes and chromatin accessibility sequencing with ATAC-seq to conduct two early pilots that aim to elucidate the systemic and molecular changes in response to physical activity. Additional features of our proposed site are analytical opportunities that include leveraging multiple exercise-related –omics data sets, such as the DGN study where we have genetic data, transcriptomes and exercise activity recorded for 922 people and have already identified multiple differentially expressed genes and gene-by-environment variants in response to exercise, and diverse and novel -omics methods for gene-by-environment, multi-omics and longitudinal data analysis. Our expectation is that this combination of production experience, exercise-relevant data and novel methods will support diverse and impact research outcomes in the MoTrPAC.
缺乏体育活动是许多健康问题的核心。尽管如此,我们有有限的

项目成果

期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)

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Stephen Montgomery其他文献

Stephen Montgomery的其他文献

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{{ truncateString('Stephen Montgomery', 18)}}的其他基金

Mapping Molecular and Phenotypic Interactions in Alzheimers Disease
绘制阿尔茨海默病的分子和表型相互作用图谱
  • 批准号:
    10574498
  • 财政年份:
    2020
  • 资助金额:
    $ 15.8万
  • 项目类别:
Mapping Molecular and Phenotypic Interactions in Alzheimers Disease
绘制阿尔茨海默病的分子和表型相互作用图谱
  • 批准号:
    10347286
  • 财政年份:
    2020
  • 资助金额:
    $ 15.8万
  • 项目类别:
Mapping Molecular and Phenotypic Interactions in Alzheimers Disease
绘制阿尔茨海默病的分子和表型相互作用图谱
  • 批准号:
    9917286
  • 财政年份:
    2020
  • 资助金额:
    $ 15.8万
  • 项目类别:
Stanford/Salk MoTrPAC Site for Genomes, Epigenomes and Transcriptomes
斯坦福/索尔克 MoTrPAC 基因组、表观基因组和转录组网站
  • 批准号:
    10318103
  • 财政年份:
    2016
  • 资助金额:
    $ 15.8万
  • 项目类别:
Predicting causal non-coding variants in a founder population
预测创始人群体中的因果非编码变异
  • 批准号:
    8792751
  • 财政年份:
    2015
  • 资助金额:
    $ 15.8万
  • 项目类别:
Predicting causal non-coding variants in a founder population
预测创始人群体中的因果非编码变异
  • 批准号:
    9306895
  • 财政年份:
    2015
  • 资助金额:
    $ 15.8万
  • 项目类别:
Predicting causal non-coding variants in a founder population
预测创始人群体中的因果非编码变异
  • 批准号:
    9116910
  • 财政年份:
    2015
  • 资助金额:
    $ 15.8万
  • 项目类别:

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