Alabama Clinical Trials Unit

描述（由申请人提供）：亚拉巴马和亚拉巴马伯明翰大学（UAB）是一个日益增长的艾滋病毒/艾滋病流行病的核心，不成比例地影响最脆弱的人群UAB艾滋病研究中心（CFAR）一直处于艾滋病毒预防和治疗调查的最前沿超过25年。 七年前，UAB CFAR成立了UAB临床试验单位（A-CTU）：UAB研究人员的合作伙伴关系，致力于在美国资源贫乏的地区进行高影响力的艾滋病毒相关研究。 A-CTU一直在进行由艾滋病毒疫苗试验网络（HVTN），杀微生物剂试验 网络（MTN）和成人临床试验组（ACTG），并共享资源在一个单一的建筑物CTU已经招募了900多名参与者进入45个独立的临床试验。此应用程序提供了添加HIV预防试验网络（HPTN）以创建单个临床研究中心（CRS）的计划。这个单一的，协调的CTU解决艾滋病毒临床研究的优先领域，并利用与患者/参与者社区建立的伙伴关系，在NIAID和行业资助的临床试验中的经验，以及与UAB CFAR研究人员的合作。 相关性：该申请寻求批准继续进行临床试验，以促进我们对艾滋病毒和相关疾病的治疗和预防的理解。亚拉巴马临床试验单位计划在伯明翰的亚拉巴马大学为几个不同的NIH赞助的网络（包括HVTN、HPTN、MTN和ACTG）进行这些试验。

DESCRIPTION (provided by applicant): Alabama and the University of Alabama Birmingham (UAB) are in the heart of a growing HIV/AIDS epidemic that disproportionately afflicts the most vulnerable populations The UAB Center for AIDS Research (CFAR) has been at the forefront of HIV prevention and therapeutic investigation for over 25 years. Seven years ago, the UAB CFAR formed the Alabama-Clinical Trials Unit (A-CTU): A partnership of UAB Investigators dedicated to conducting high-impact HIV-related studies in a resource poor region of the United States. The A-CTU has been conducting clinical studies sponsored by the HIV Vaccine Trials Network (HVTN), the Microbicide Trials Network (MTN), and the Adult Clinical Trials Group (ACTG) and shares resources In a single building The CTU has enrolled over 900 participants Into 45 separate clinical trials. This application provides plans to add the HIV Prevention Trials Network (HPTN) to create a single Clinical Research Site (CRS). This single, coordinated CTU addresses priority areas in HIV clinical research and utilizes established partnerships with the patient/participant community, experience In NIAID- and Industry-funded clinical trials, and collaborations with UAB CFAR investigators. RELEVANCE: This application seeks approval to continue conducting clinical trials to advance our understanding of the treatment and prevention of HIV and related diseases. The Alabama Clinical Trials Unit plans to conduct these trials for several different NIH-sponsored networks Including the HVTN, HPTN, MTN, and ACTG at a the University of Alabama at Birmingham.