New Proteomic and Genome Engineering Approaches to Decipher Astrocyte Function at Synapses
破译星形胶质细胞突触功能的新蛋白质组学和基因组工程方法
基本信息
- 批准号:9789247
- 负责人:
- 金额:$ 70.53万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2018
- 资助国家:美国
- 起止时间:2018-09-30 至 2021-06-30
- 项目状态:已结题
- 来源:
- 关键词:AffectAgeAstrocytesBiochemicalBrainBrain DiseasesBrain regionC-terminalCRISPR/Cas technologyCell Adhesion MoleculesCell surfaceChimeric ProteinsCognitionComplementComplexDataDevelopmentDiseaseDisease modelEvolutionFunctional disorderFutureGene ExpressionGenome engineeringGoalsHomeostasisHumanImpairmentIndividualKnock-outKnowledgeLabelLeadLinkMass Spectrum AnalysisMediatingMembraneMethodsMolecularMolecular ProfilingMonitorMusMutationN-terminalNervous System PhysiologyNeurogliaNeuronsNeurosciencesPathologyPathway interactionsProblem SolvingProcessPropertyProteinsProteomeProteomicsReactionRegulationResourcesRoleScienceSpecific qualifier valueStructureSurfaceSynapsesSynaptic TransmissionSynaptosomesTechniquesTestingThinnessTouch sensationViralWorkbaseblindbrain cellcell typeextracellulargenome editingin vivoinnovationinsightmouse modelnervous system disorderneuroregulationnovelpostsynapticprotein complexreconstitutionsynaptic functionsynaptogenesistool
项目摘要
ABSTRACT
Astrocytes are the most abundant glial cells in the human brain. Interactions of astrocytes with synapses via thin
perisynaptic astrocytic processes are critical for proper synaptic connectivity and function. Each mouse astrocyte
sends out an extensive array of processes that are estimated to contact over 100,000 synapses. The number of
astrocytes and the extent of their interactions with synapses have increased throughout evolution, indicating a
close link between astrocytes and cognition. Moreover, emerging evidence suggests that dysfunction of
astrocyte-synapse interactions contributes to a variety of brain disorders. In contrast to neuronal synaptic
structures, however, we are largely blind to the molecular composition and mechanisms of the astrocytic
perisynaptic structures. Moreover, there is currently very little understanding of how mutations that disrupt
astrocyte-synapse interactions lead to synaptic pathologies. This is in large part because, unlike neuronal
synaptic structures, it has not been possible to purify and identify proteins enriched at subcellular regions of
astrocytes. In this project, we will develop and utilize innovative proteomic and genome editing approaches to
solve these problems, revealing the proteins and inner workings of astrocyte processes that associate with and
modulate synapses. We anticipate these data will provide a new and unparalleled molecular framework for future
studies on astrocyte- neuron interactions.
摘要
项目成果
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{{ truncateString('Cagla Eroglu', 18)}}的其他基金
Astrocyte Modulation of Neural Circuit Function and Behavior
星形胶质细胞对神经回路功能和行为的调节
- 批准号:
10294800 - 财政年份:2021
- 资助金额:
$ 70.53万 - 项目类别:
Astrocyte Modulation of Neural Circuit Function and Behavior
星形胶质细胞对神经回路功能和行为的调节
- 批准号:
10461222 - 财政年份:2021
- 资助金额:
$ 70.53万 - 项目类别:
Linking Neuron-Astrocyte Communication to Long-Term Changes in Neural Circuit Function and Behavior
将神经元-星形胶质细胞通讯与神经回路功能和行为的长期变化联系起来
- 批准号:
10294805 - 财政年份:2021
- 资助金额:
$ 70.53万 - 项目类别:
Linking Neuron-Astrocyte Communication to Long-Term Changes in Neural Circuit Function and Behavior
将神经元-星形胶质细胞通讯与神经回路功能和行为的长期变化联系起来
- 批准号:
10461227 - 财政年份:2021
- 资助金额:
$ 70.53万 - 项目类别:
Linking Neuron-Astrocyte Communication to Long-Term Changes in Neural Circuit Function and Behavior
将神经元-星形胶质细胞通讯与神经回路功能和行为的长期变化联系起来
- 批准号:
10693174 - 财政年份:2021
- 资助金额:
$ 70.53万 - 项目类别:
Astrocyte Modulation of Neural Circuit Function and Behavior
星形胶质细胞对神经回路功能和行为的调节
- 批准号:
10693161 - 财政年份:2021
- 资助金额:
$ 70.53万 - 项目类别:
Control of Astrocyte Development and Astrocyte-Synapse Interactions
星形胶质细胞发育和星形胶质细胞突触相互作用的控制
- 批准号:
9930268 - 财政年份:2019
- 资助金额:
$ 70.53万 - 项目类别:
Control of Astrocyte Development and Astrocyte-Synapse Interactions
星形胶质细胞发育和星形胶质细胞突触相互作用的控制
- 批准号:
9900048 - 财政年份:2018
- 资助金额:
$ 70.53万 - 项目类别:
Control of Astrocyte Development and Astrocyte-Synapse Interactions
星形胶质细胞发育和星形胶质细胞突触相互作用的控制
- 批准号:
10376297 - 财政年份:2018
- 资助金额:
$ 70.53万 - 项目类别:
The Regulation of Synaptic Connectivity and Homeostasis by Huntingtin
亨廷顿蛋白对突触连接和稳态的调节
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9083719 - 财政年份:2016
- 资助金额:
$ 70.53万 - 项目类别:
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