课题基金 / 基金详情

Identification of human genomic signatures of episodic memory

Identification of human genomic signatures of episodic memory
情景记忆的人类基因组特征的识别
批准号:
9789072
负责人:
Genevieve Konopka
金额:
$24.3万
依托单位国家:
美国
项目类别:
财政年份:
2018
资助国家:
美国
项目状态:
已结题
起止时间:
2018-09-20 至 2021-07-31

项目摘要

项目成果

Genevieve Konopka的其他基金

相似基金

相关文献

中文摘要
翻译
项目总结
英文摘要
PROJECT SUMMARY Our proposal seeks to unite two powerful tools in contemporary neuroscience: brain recordings from awake, behaving individuals and large-scale gene expression from human brain tissue. We hope to understand more about cognitive function in epilepsy and other disorders by studying gene expression profiles linked with brain oscillation information. The key innovation of this proposal is the collection of these two types of data from the same patients at different stages of their evaluation and treatment for epilepsy. In our first aim, we will build upon our recent findings examining gene/oscillation correlations through the generation of a proposed new large dataset of brain oscillations and by extending our analysis to include item retrieval during episodic memory. In our second aim, we will build an entirely new dataset by collecting intracranial EEG oscillatory data as subjects perform an episodic memory task and then also collect temporal lobe tissue specimens from the same patients. This is because the patients first undergo seizure mapping with intracranial electrodes, and then undergo resection of the temporal lobe. This offers the possibility of capturing oscillatory and gene expression data from the same tissue across subjects. In our third aim, we will generate gene expression data from surgical epilepsy patients and compare these profiles to datasets derived from cadaveric tissue samples. These comparisons will serve as a control to help interpret our correlation results and as a substantial contribution to the literature in its own right. Although this ambitious plan requires close integration between labs with expertise in gene expression analysis and signal processing, and requires a pipeline for processing tissue obtained in the operating room as well as specific surgical techniques to produce good specimens, the methodological groundwork we have established and preliminary data we show demonstrate that our plans have a high chance of success. The genes we identify as being highly correlated with mnemonic processing will be strong candidates for further animal experimentation and potential therapeutic targeting. We believe this line of investigation is a novel way to address the problem of cognitive decline in epilepsy and potentially other disorders such as mild cognitive impairment.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Foxp-regulated signaling pathways in brain development - Diversity
  • 批准号:
    10478320
  • 项目类别:
  • 资助金额:
    $8.02万
  • 财政年份:
    2022
  • 负责人:
    Genevieve Konopka
  • 依托单位:
Deciphering the genomic mechanisms underlying the physiology of human brain stimulation
  • 批准号:
    10559426
  • 项目类别:
  • 资助金额:
    $379.03万
  • 财政年份:
    2022
  • 负责人:
    Genevieve Konopka
  • 依托单位:
Foxp-regulated signaling pathways in brain development
  • 批准号:
    10425442
  • 项目类别:
  • 资助金额:
    $61.09万
  • 财政年份:
    2021
  • 负责人:
    Genevieve Konopka
  • 依托单位:
Comparative Epigenomics of Primate Brains
海外基金