1/24 Healthy Brain and Child Development National Consortium

项目摘要/摘要 神经发育过程是由基因和环境之间的动态相互作用塑造的。 生命早期的不良适应经历会改变发育轨迹，导致有害和持久的 发育后遗症。出生前和出生后的危险包括母亲接触物质、毒物 孕期和早期接触、产妇健康状况、父母精神病、虐待、 结构性种族主义和过度的压力。阐明各种环境危害对儿童的影响 在发展方面，当务之急是制定一个关于#年头10年发展轨迹的标准模板 生活应该建立在足够大和人口结构多样化的美国人口样本基础上。至 为此，健康大脑和儿童发展国家联盟(HBCD-NC)已经成立 部署一套协调、优化和创新的神经成像(MRI、EEG)措施 通过广泛的行为学、生理学和心理学工具以及生物标本来理解 在24个地点登记的7500名母亲和婴儿的神经发育轨迹 美国(美国)。HBCD-NC将在HBCD的指导下执行一项共同的研究协议-- NC管理核心(HCAC)，并将汇集和分发一项全面和精心策划的研究 在HBCD-NC数据协调中心的指导下向整个科学界提供数据集 (HDCC)。HBCD-NC的总体目标是创建一个全面、协调和高质量的 将描述美国儿童典型神经发育轨迹的维度数据集 评估生物和环境暴露如何影响这些轨迹。特别强调的是 理解出生前和出生后接触阿片类药物、大麻、酒精、烟草的影响 和/或其他物质。为了实现这些广泛的目标，参加调查的妇女样本将包括：1)a) 代表美国人口的种族、民族和社会经济多元化群体；2) 使用目标物质(类阿片、大麻、酒精、烟草)的孕妇；和3) 在人口学和行为上相似的妇女，在怀孕期间没有使用药物以实现有效的因果关系 推论。此外，HBCD-NC将确定关键的发展窗口，在此期间，有害和 保护性环境对以后的神经发育结果影响最大。大型的，多个- 这项研究将首次产生的模式、纵向和可概化的数据集将提供 使用最先进的方法对儿童发展的新见解。HBCD-NC研究将向公众通报 改善全国儿童健康和发展的政策。

Project Summary/Abstract Neurodevelopmental processes are shaped by dynamic interactions between genes and environments. Maladaptive experiences early in life can alter developmental trajectories, leading to harmful and enduring developmental sequelae. Pre- and postnatal hazards include maternal substance exposure, toxicant exposures in pregnancy and early life, maternal health conditions, parental psychopathology, maltreatment, structural racism, and excessive stress. To elucidate how various environmental hazards impact child development, it is imperative that a normative template of developmental trajectories over the first 10 years of life be established based on a sufficiently large and demographically diverse sample of the US population. To accomplish this, the Healthy Brain and Child Development National Consortium (HBCD-NC) has been formed to deploy a harmonized, optimized, and innovative set of neuroimaging (MRI, EEG) measures complemented by an extensive battery of behavioral, physiological, and psychological tools, and biospecimens to understand neurodevelopmental trajectories in a sample of 7,500 mothers and infants enrolled at 24 sites across the United States (US). The HBCD-NC will carry out a common research protocol under direction of the HBCD- NC Administrative Core (HCAC) and will assemble and distribute a comprehensive and well-curated research dataset to the scientific community at large under the direction of the HBCD-NC Data Coordinating Center (HDCC). The overarching goal of the HBCD-NC is to create a comprehensive, harmonized, and high- dimensional dataset that will characterize typical neurodevelopmental trajectories in US children and that will assess how biological and environmental exposures affect those trajectories. A special emphasis will be placed on understanding the impact of pre- and postnatal exposure to opioids, marijuana, alcohol, tobacco and/or other substances. To address these broad objectives, the sample of women enrolled will include: 1) a racially, ethnically, and socioeconomically diverse cohort that is representative of the US population; 2) pregnant woman with use of targeted substances (opioids, marijuana, alcohol, tobacco); and 3) demographically and behaviorally similar women without substance use in pregnancy to enable valid causal inferences. In addition, the HBCD-NC will identify key developmental windows during which both harmful and protective environments have the most influence on later neurodevelopmental outcomes. The large, multi- modal, longitudinal, and generalizable dataset that will be produced for the first time by this study will provide novel insights into child development using state-of-the-art methods. The HBCD-NC study will inform public policy to improve the health and development of children across the nation.