Wearable Sweat Sensor for Non-invasive Wireless Monitoring of Heart Failure

项目摘要 心力衰竭(HF)是一种非常常见、代价高昂、具有潜在致命性的健康疾病，影响着4000多万人 全球各地的人。移动健康技术在改善心力衰竭门诊管理方面的作用正在显现。 然而，目前大多数基于mHealth的心力衰竭监测系统，测量血压， 体重和心电图记录并没有显示全因死亡率的下降。人类的汗水是 一种关键的体液，含有丰富的分析物，包括在HF中被密切监测的电解质 患者(如钾)和关键心力衰竭生物标志物(如脑利钠肽(BNP))。因此，汗水可能 作为开发非侵入性和动态心力衰竭监测的mHealth工具的完美候选者。 在这个方案中，我们的目标是开发一种集成的可穿戴汗液传感器贴片，用于非侵入性、个性化、 和心力衰竭的动态监测。建议的可穿戴汗液传感器平台可以执行 通过集成的离子导入模块自动感应汗液，通过 微流体通道，汗液电解质(即钾)的连续分析以及临床上的其他 心力衰竭的相关生物标志物(即BNP)。传感器的体内验证及动态相关性研究 将使用可穿戴汗液传感器对健康人群进行血清和汗液电解质和生物标记物的检测 研究对象。将进行进一步的人体试验，以确定心力衰竭患者的汗液分析是否 可以可靠地评估电解质和生物标记物水平，并将可穿戴汗液传感器集成到 整合mHealth平台，监测慢性心力衰竭患者的生理参数。充分利用 我们团队的跨学科教育和研究背景，横跨化学、工程、 和心血管医学，下面的提案将允许我们的团队开发可穿戴汗液传感器 探索监测心力衰竭患者临床相关生物标志物的新方法。成功之路 该项目的实施将把移动健康管理、监测和反馈统一到一个可穿戴平台中。 这一平台不仅有可能彻底改变慢性心力衰竭的管理，而且还将 通过发现一种有意义的方式整合使用 将可穿戴电子设备转化为慢性病模型。

Project Summary Heart failure (HF) is a very common, costly and potentially fatal health condition which affects over 40 million people globally. The role of mHealth technologies in improving the outpatient management of HF is emerging. However, the majority of the current mHealth based HF monitoring systems, which measure blood pressure, weight, and electrocardiographic recordings, did not show a reduction in all-cause mortality. Human sweat is a key body fluid that contains a wealth of analytes, including electrolytes that are closely monitored in HF patients (e.g., potassium) and key HF biomarkers (e.g., brain natriuretic peptide (BNP)). Thus, sweat could serve as a perfect candidate for developing mHealth tools toward non-invasive and dynamic HF monitoring. In this proposal, we aim to develop an integrated wearable sweat sensor patch for non-invasive, personalized, and dynamic monitoring of heart failure. The proposed wearable sweat sensor platform can perform autonomous sweat induction through an integrated iontophoresis module, efficient sweat sampling through microfluidic channels, and continuous analysis of sweat electrolytes (i.e. potassium) as well as other clinically relevant biomarkers for heart failure (i.e. BNP). The in vivo sensor validation and dynamic correlation study of serum and sweat electrolytes and biomarkers using the wearable sweat sensor will be performed in healthy subjects. Further human trials will be implemented to determine whether sweat analysis in patients with HF can reliably assess electrolyte and biomarker levels, and incorporate a wearable sweat sensor into an integrated mHealth platform to monitor physiological parameters in chronic HF. Harnessing the strengths of our team’s interdisciplinary educational and research background, spanning across chemistry, engineering, and cardiovascular medicine, the following proposal will allow our team to develop a wearable sweat sensor patch to explore the novel method of monitoring clinically relevant biomarkers in patients with HF. The success of this project will unify mobile health management, monitoring and feedback into a single wearable platform. This platform has the potential to not only revolutionize the management of chronic heart failure, but also to significantly impact the healthcare industry by discovering a meaningful way to incorporate the use of wearable electronics into a chronic disease model.