Wearable Sweat Sensor for Non-invasive Wireless Monitoring of Heart Failure

用于心力衰竭无创无线监测的可穿戴汗液传感器

基本信息

  • 批准号:
    10022517
  • 负责人:
  • 金额:
    $ 18.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2019
  • 资助国家:
    美国
  • 起止时间:
    2019-09-23 至 2022-07-31
  • 项目状态:
    已结题

项目摘要

Project Summary Heart failure (HF) is a very common, costly and potentially fatal health condition which affects over 40 million people globally. The role of mHealth technologies in improving the outpatient management of HF is emerging. However, the majority of the current mHealth based HF monitoring systems, which measure blood pressure, weight, and electrocardiographic recordings, did not show a reduction in all-cause mortality. Human sweat is a key body fluid that contains a wealth of analytes, including electrolytes that are closely monitored in HF patients (e.g., potassium) and key HF biomarkers (e.g., brain natriuretic peptide (BNP)). Thus, sweat could serve as a perfect candidate for developing mHealth tools toward non-invasive and dynamic HF monitoring. In this proposal, we aim to develop an integrated wearable sweat sensor patch for non-invasive, personalized, and dynamic monitoring of heart failure. The proposed wearable sweat sensor platform can perform autonomous sweat induction through an integrated iontophoresis module, efficient sweat sampling through microfluidic channels, and continuous analysis of sweat electrolytes (i.e. potassium) as well as other clinically relevant biomarkers for heart failure (i.e. BNP). The in vivo sensor validation and dynamic correlation study of serum and sweat electrolytes and biomarkers using the wearable sweat sensor will be performed in healthy subjects. Further human trials will be implemented to determine whether sweat analysis in patients with HF can reliably assess electrolyte and biomarker levels, and incorporate a wearable sweat sensor into an integrated mHealth platform to monitor physiological parameters in chronic HF. Harnessing the strengths of our team’s interdisciplinary educational and research background, spanning across chemistry, engineering, and cardiovascular medicine, the following proposal will allow our team to develop a wearable sweat sensor patch to explore the novel method of monitoring clinically relevant biomarkers in patients with HF. The success of this project will unify mobile health management, monitoring and feedback into a single wearable platform. This platform has the potential to not only revolutionize the management of chronic heart failure, but also to significantly impact the healthcare industry by discovering a meaningful way to incorporate the use of wearable electronics into a chronic disease model.
项目摘要 心力衰竭(HF)是一种非常常见、昂贵且可能致命的健康状况,影响超过4000万人 全球的人。移动医疗技术在改善HF门诊管理方面的作用正在显现。 然而,目前大多数基于mHealth的HF监测系统,其测量血压, 体重和心电图记录并没有显示全因死亡率的降低。人类的汗水 一种含有大量分析物的关键体液,包括HF中密切监测的电解质 患者(例如,钾)和关键的HF生物标志物(例如,脑利钠肽(BNP))。因此,汗水可以 作为一个完美的候选人开发mHealth工具对非侵入性和动态HF监测。 在这项提案中,我们的目标是开发一种集成的可穿戴汗液传感器贴片,用于非侵入性,个性化, 和心力衰竭的动态监测。所提出的可穿戴汗液传感器平台可以执行 通过集成的离子电渗模块进行自主汗液感应, 微流控通道和汗液电解质(即钾)的连续分析以及其他临床应用。 心力衰竭的相关生物标志物(即BNP)。体内传感器验证和动态相关性研究 使用可穿戴汗液传感器的血清和汗液电解质和生物标志物的检测将在健康人群中进行。 科目将进行进一步的人体试验,以确定HF患者的汗液分析是否 可以可靠地评估电解质和生物标志物水平,并将可穿戴汗液传感器纳入 集成mHealth平台,用于监测慢性HF的生理参数。利用 我们团队的跨学科教育和研究背景,跨越化学,工程, 和心血管医学,以下建议将允许我们的团队开发一种可穿戴的汗液传感器, 探索监测HF患者临床相关生物标志物的新方法。成功 将把移动的健康管理、监测和反馈统一到一个可穿戴平台上。 该平台不仅有可能彻底改变慢性心力衰竭的管理, 通过发现一种有意义的方式来整合使用 可穿戴电子设备到慢性疾病模型中。

项目成果

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Wei Gao其他文献

Wei Gao的其他文献

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{{ truncateString('Wei Gao', 18)}}的其他基金

1/24 Healthy Brain and Child Development National Consortium
1/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10494206
  • 财政年份:
    2021
  • 资助金额:
    $ 18.87万
  • 项目类别:
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease
用于检测和监测心脏代谢疾病的激光雕刻可穿戴汗液传感器
  • 批准号:
    10297703
  • 财政年份:
    2021
  • 资助金额:
    $ 18.87万
  • 项目类别:
1/24 Healthy Brain and Child Development National Consortium
1/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10378875
  • 财政年份:
    2021
  • 资助金额:
    $ 18.87万
  • 项目类别:
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease
用于检测和监测心脏代谢疾病的激光雕刻可穿戴汗液传感器
  • 批准号:
    10680422
  • 财政年份:
    2021
  • 资助金额:
    $ 18.87万
  • 项目类别:
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease
用于检测和监测心脏代谢疾病的激光雕刻可穿戴汗液传感器
  • 批准号:
    10473756
  • 财政年份:
    2021
  • 资助金额:
    $ 18.87万
  • 项目类别:
Planning Phase for the Healthy Brain and Child Development Study (HEALthy BCD) in Los Angeles County Area
洛杉矶县地区健康大脑和儿童发展研究 (HEALthy BCD) 的规划阶段
  • 批准号:
    9900529
  • 财政年份:
    2019
  • 资助金额:
    $ 18.87万
  • 项目类别:
Planning Phase for the Healthy Brain and Child Development Study (HEALthy BCD) in Los Angeles County Area
洛杉矶县地区健康大脑和儿童发展研究 (HEALthy BCD) 的规划阶段
  • 批准号:
    10017557
  • 财政年份:
    2019
  • 资助金额:
    $ 18.87万
  • 项目类别:
Effects of Prenatal Opiates on Infant Brain and Neurobehavioral Development
产前阿片类药物对婴儿大脑和神经行为发育的影响
  • 批准号:
    10197069
  • 财政年份:
    2018
  • 资助金额:
    $ 18.87万
  • 项目类别:
Effects of Prenatal Opiates on Infant Brain and Neurobehavioral Development
产前阿片类药物对婴儿大脑和神经行为发育的影响
  • 批准号:
    10619361
  • 财政年份:
    2018
  • 资助金额:
    $ 18.87万
  • 项目类别:
Effects of Prenatal Opiates on Infant Brain and Neurobehavioral Development
产前阿片类药物对婴儿大脑和神经行为发育的影响
  • 批准号:
    10436297
  • 财政年份:
    2018
  • 资助金额:
    $ 18.87万
  • 项目类别:

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