Wearable Sweat Sensor for Non-invasive Wireless Monitoring of Heart Failure

用于心力衰竭无创无线监测的可穿戴汗液传感器

• 批准号: 10022517
• 负责人: Wei Gao
• 金额: $ 18.87万
• 依托单位: CALIFORNIA INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-09-23 至 2022-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10022517
• 关键词: Affect; Biological; Biological Markers; Blood Pressure; Blood specimen; Body Fluids; Brain natriuretic peptide; Calibration; Cardiovascular system; Chemical Stimulation; Chemistry; Chronic Disease; Collection; Communication; Congestive Heart Failure; Correlation Studies; Disease model; Electrolytes; Electronics; Engineering; Feedback; Functional disorder; Goals; Health; Healthcare Industry; Heart failure; Human; Institutional Review Boards; Investigation; Iontophoresis; Measurement; Measures; Medical; Medicine; Methods; Microfluidics; Monitor; Morphologic artifacts; Outpatients; Patients; Physiologic Monitoring; Physiological; Potassium; Provider; Research; Role; Sampling; Scheme; Sensitivity and Specificity; Study of serum; Sweat test; System; Technology; Time; Transistors; Validation; Weight; Wireless Technology; base; clinically relevant; cost; design; electric impedance; flexibility; health management; improved; in vivo; mHealth; mortality; nanomaterials; novel; sensor; success; tool; wearable device; wearable sensor technology

Project Summary Heart failure (HF) is a very common, costly and potentially fatal health condition which affects over 40 million people globally. The role of mHealth technologies in improving the outpatient management of HF is emerging. However, the majority of the current mHealth based HF monitoring systems, which measure blood pressure, weight, and electrocardiographic recordings, did not show a reduction in all-cause mortality. Human sweat is a key body fluid that contains a wealth of analytes, including electrolytes that are closely monitored in HF patients (e.g., potassium) and key HF biomarkers (e.g., brain natriuretic peptide (BNP)). Thus, sweat could serve as a perfect candidate for developing mHealth tools toward non-invasive and dynamic HF monitoring. In this proposal, we aim to develop an integrated wearable sweat sensor patch for non-invasive, personalized, and dynamic monitoring of heart failure. The proposed wearable sweat sensor platform can perform autonomous sweat induction through an integrated iontophoresis module, efficient sweat sampling through microfluidic channels, and continuous analysis of sweat electrolytes (i.e. potassium) as well as other clinically relevant biomarkers for heart failure (i.e. BNP). The in vivo sensor validation and dynamic correlation study of serum and sweat electrolytes and biomarkers using the wearable sweat sensor will be performed in healthy subjects. Further human trials will be implemented to determine whether sweat analysis in patients with HF can reliably assess electrolyte and biomarker levels, and incorporate a wearable sweat sensor into an integrated mHealth platform to monitor physiological parameters in chronic HF. Harnessing the strengths of our team’s interdisciplinary educational and research background, spanning across chemistry, engineering, and cardiovascular medicine, the following proposal will allow our team to develop a wearable sweat sensor patch to explore the novel method of monitoring clinically relevant biomarkers in patients with HF. The success of this project will unify mobile health management, monitoring and feedback into a single wearable platform. This platform has the potential to not only revolutionize the management of chronic heart failure, but also to significantly impact the healthcare industry by discovering a meaningful way to incorporate the use of wearable electronics into a chronic disease model.

项目摘要 心力衰竭（HF）是一种非常普遍，昂贵且可能致命的健康状况，影响超过4000万 全球人。 MHealth技术在改善HF门诊管理中的作用正在出现。 但是，当前基于MHealth的HF监测系统的大多数，该系统测量血压， 体重和心电图记录并未显示出全因死亡率的降低。人汗是 包含大量分析物的关键体液，包括在HF中密切监测的电解质 患者（例如钾）和关键的HF生物标志物（例如脑脂肪肽（BNP））。那可以 作为开发MHealth工具进行非侵入性和动态HF监测的理想选择。 在此提案中，我们旨在开发一个集成的可穿戴汗液传感器补丁，以用于非侵入性，个性化， 和动态监测心力衰竭。拟议的可穿戴汗水传感器平台可以执行 通过集成的离子噬菌体模块的自主汗感应，通过 微流体通道以及汗液电解质（即钾）以及其他临床上的连续分析 心力衰竭的相关生物标志物（即BNP）。体内传感器验证和动态相关研究 使用可穿戴汗液传感器的血清和汗水电解质和生物标志物将在健康中进行 主题。将实施进一步的人类试验，以确定HF患者的汗水分析是否 可以可靠地评估电解质和生物标志物水平，并将可穿戴汗液传感器纳入 集成的MHealth平台以监测慢性HF中的生理参数。利用 我们团队的跨学科教育和研究背景跨越化学，工程， 和心血管医学，以下建议将使我们的团队能够开发可穿戴的汗水传感器 补丁以探索HF患者中临床相关生物标志物的新方法。成功 该项目将将移动健康管理，监视和反馈统一为一个可穿戴平台。 该平台不仅有可能彻底改变慢性心力衰竭的管理 通过发现一种有意义的方法来纳入使用 可穿戴电子产品成慢性病模型。