Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease

用于检测和监测心脏代谢疾病的激光雕刻可穿戴汗液传感器

基本信息

  • 批准号:
    10680422
  • 负责人:
  • 金额:
    $ 39.87万
  • 依托单位:
  • 依托单位国家:
    美国
  • 项目类别:
  • 财政年份:
    2021
  • 资助国家:
    美国
  • 起止时间:
    2021-08-23 至 2026-07-31
  • 项目状态:
    未结题

项目摘要

PROJECT SUMMARY Metabolic syndrome is on the rise as the leading cause of morbidity and mortality, affecting more than a third of all U.S. adults. If untreated, patients who develop type 2 diabetes mellitus (T2D) are at high-risk for major adverse cardiovascular events, including stroke, myocardial infarction, and cardiovascular related deaths. Despite chronic screening and monitoring for patient-specific prediction and prevention for cardiometabolic disease, there remains a bottleneck to detect and monitor the metabolic risk factors underlying the rising epidemic of obesity-associated with hyperlipidemia, hypertension, and diabetes. For these reasons, developing wearable molecular sensors, which allow for seamless screening, monitoring, and potentially enables timely intervention, is clinically significant to confront the rising endemic of cardiometabolic disorders. In this project, we propose to continuously monitor a panel of key metabolic biomarkers including glucose, uric acid, branched-chain amino acids (BCAAs: leucine, isoleucine, and valine), and insulin using an integrated Molecular Sensing System (iMSS). We hypothesize that seamless detection of cardiometabolic biomarkers accelerates our capacity to identify metabolic risk factors in our prediabetic patients with obesity for early nutrition intervention to reduce health disparities in the U.S. In addition to integrating with our existing glucose and uric acid sensors, we propose to develop novel laser-engraved wearable sensors for continuous monitoring of BCAAs and insulin based on a novel nanobiosensing approach that combines high-throughput laser-fabricated graphene, molecular imprinting based ‘artificial antibody’, and in situ sensor regeneration technique. This approach will enable large-scale, low-cost fabrication of highly sensitive and selective sensors for continuous monitoring of clinical meaningful cardiometabolic analytes in human sweat at ultralow concentrations (such as BCAAs). The use of laser-induced microfluidics and numerical simulation-guided design optimization enables efficient fluid sampling with minimized effects from the sensing delay and fluid evaporation. Harnessing the power of concurrent multiplexed cardiometabolic sensing, adjusted electrochemical measurements based on pH, electrolytes, temperature, and sweat rate calibration minimize the systematic uncertainties persisted in the current generation of wearable sensing systems. We will validate the correlation of the sweat/blood biomarkers in healthy subjects using the iMSS and deploy these epidermal sensors to the high-risk patients. We envision that the iMSS system will provide an entry point to identify pre- diabetes and obesity at risk for conversion to T2D, and will have translational significance to mitigate clinical manifestation of major adverse cardiovascular events.
项目总结

项目成果

期刊论文数量(12)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
An autonomous wearable biosensor powered by a perovskite solar cell
  • DOI:
    10.1038/s41928-023-00996-y
  • 发表时间:
    2023-07-20
  • 期刊:
  • 影响因子:
    34.3
  • 作者:
    Min, Jihong;Demchyshyn, Stepan;Gao, Wei
  • 通讯作者:
    Gao, Wei
Artificial intelligence-powered electronic skin
  • DOI:
    10.1038/s42256-023-00760-z
  • 发表时间:
    2023-12
  • 期刊:
  • 影响因子:
    23.8
  • 作者:
    Changhao Xu;Samuel A. Solomon;Wei Gao
  • 通讯作者:
    Changhao Xu;Samuel A. Solomon;Wei Gao
Flexible Electronics and Devices as Human-Machine Interfaces for Medical Robotics.
  • DOI:
    10.1002/adma.202107902
  • 发表时间:
    2022-04
  • 期刊:
  • 影响因子:
    29.4
  • 作者:
    Heng, Wenzheng;Solomon, Samuel;Gao, Wei
  • 通讯作者:
    Gao, Wei
All-printed soft human-machine interface for robotic physicochemical sensing.
用于机器人理化传感的全印刷软人机界面。
  • DOI:
    10.1126/scirobotics.abn0495
  • 发表时间:
    2022-06
  • 期刊:
  • 影响因子:
    25
  • 作者:
  • 通讯作者:
A wearable electrochemical biosensor for the monitoring of metabolites and nutrients.
  • DOI:
    10.1038/s41551-022-00916-z
  • 发表时间:
    2022-11
  • 期刊:
  • 影响因子:
    28.1
  • 作者:
    Wang, Minqiang;Yang, Yiran;Min, Jihong;Song, Yu;Tu, Jiaobing;Mukasa, Daniel;Ye, Cui;Xu, Changhao;Heflin, Nicole;McCune, Jeannine S.;Hsiai, Tzung K.;Li, Zhaoping;Gao, Wei
  • 通讯作者:
    Gao, Wei
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Wei Gao其他文献

Wei Gao的其他文献

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{{ truncateString('Wei Gao', 18)}}的其他基金

1/24 Healthy Brain and Child Development National Consortium
1/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10494206
  • 财政年份:
    2021
  • 资助金额:
    $ 39.87万
  • 项目类别:
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease
用于检测和监测心脏代谢疾病的激光雕刻可穿戴汗液传感器
  • 批准号:
    10297703
  • 财政年份:
    2021
  • 资助金额:
    $ 39.87万
  • 项目类别:
1/24 Healthy Brain and Child Development National Consortium
1/24 健康大脑和儿童发展国家联盟
  • 批准号:
    10378875
  • 财政年份:
    2021
  • 资助金额:
    $ 39.87万
  • 项目类别:
Laser-Engraved Wearable Sweat Sensors to Detect and Monitor Cardiometabolic Disease
用于检测和监测心脏代谢疾病的激光雕刻可穿戴汗液传感器
  • 批准号:
    10473756
  • 财政年份:
    2021
  • 资助金额:
    $ 39.87万
  • 项目类别:
Planning Phase for the Healthy Brain and Child Development Study (HEALthy BCD) in Los Angeles County Area
洛杉矶县地区健康大脑和儿童发展研究 (HEALthy BCD) 的规划阶段
  • 批准号:
    9900529
  • 财政年份:
    2019
  • 资助金额:
    $ 39.87万
  • 项目类别:
Wearable Sweat Sensor for Non-invasive Wireless Monitoring of Heart Failure
用于心力衰竭无创无线监测的可穿戴汗液传感器
  • 批准号:
    10022517
  • 财政年份:
    2019
  • 资助金额:
    $ 39.87万
  • 项目类别:
Planning Phase for the Healthy Brain and Child Development Study (HEALthy BCD) in Los Angeles County Area
洛杉矶县地区健康大脑和儿童发展研究 (HEALthy BCD) 的规划阶段
  • 批准号:
    10017557
  • 财政年份:
    2019
  • 资助金额:
    $ 39.87万
  • 项目类别:
Effects of Prenatal Opiates on Infant Brain and Neurobehavioral Development
产前阿片类药物对婴儿大脑和神经行为发育的影响
  • 批准号:
    10197069
  • 财政年份:
    2018
  • 资助金额:
    $ 39.87万
  • 项目类别:
Effects of Prenatal Opiates on Infant Brain and Neurobehavioral Development
产前阿片类药物对婴儿大脑和神经行为发育的影响
  • 批准号:
    10619361
  • 财政年份:
    2018
  • 资助金额:
    $ 39.87万
  • 项目类别:
Effects of Prenatal Opiates on Infant Brain and Neurobehavioral Development
产前阿片类药物对婴儿大脑和神经行为发育的影响
  • 批准号:
    10436297
  • 财政年份:
    2018
  • 资助金额:
    $ 39.87万
  • 项目类别:

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