Mwanza-Tanzania Research Training Program in HIV Clinical Investigation

姆万扎-坦桑尼亚艾滋病毒临床研究研究培训项目

• 批准号: 10374941
• 负责人: Daniel W Fitzgerald
• 金额: $ 30万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2026-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374941
• 关键词: AIDS prevention; Africa; Appointment; Area; Behavioral Research; Cardiovascular Diseases; Caring; Clinical Investigator; Clinical Trials; Collaborations; Doctor of Pharmacy; Doctor of Philosophy; Funding; Goals; HIV; HIV Infections; Human immunodeficiency virus test; Hygiene; Institutes; Institution; Intervention Studies; Intervention Trial; Investigation; London; Medical Research; Outcome; Patients; Phase; Physicians; Postdoctoral Fellow; Preparation; Prevention Research; Research; Research Project Grants; Research Training; Schools; Scientist; Tanzania; Training; Training Programs; Tropical Medicine; United States National Institutes of Health; Vaccine Research; Women' s Health; clinical investigation; co-infection; epidemiology study; improved; individual patient; institutional capacity; medical schools; patient oriented; patient oriented research; pragmatic trial; prevent; programs

The program will strengthen patient-oriented HIV clinical investigation training of physician-scientists and other exceptional clinicians in Mwanza, in northwestern Tanzania. The program builds upon two decades of collaboration and capacity building by the partner institutions. The primary research institution in Tanzania will be the Mwanza Intervention Trials Unit (MITU), which is a unit of Tanzania’s National Institute for Medical Research (NIMR). MITU was established in 2006 as a collaboration between NIMR and the London School of Hygiene and Tropical Medicine (LSHTM) to strengthen HIV interventional research in Tanzania. MITU collaborates closely with the Weill Bugando School of Medicine, which is also located in Mwanza. Weill Bugando was established in 2003 to train physicians for northwestern Tanzania. MITU and Weill Bugando have collaborated with Weill Cornell Medical College since their founding. This research training program aims to fill a critical gap in Mwanza: the need for Tanzanian physicians with rigorous training in patient-oriented HIV clinical investigation. We use the NIH definition of clinical investigation as research which directly interacts with individual patients or clusters of patients in Phase I, II, or III clinical trials, pragmatic trials, or formative epidemiologic or behavioral research in preparation for clinical trials. The goals of the proposed training program are: 1.To increase the number of clinical investigators at MITU and thereby increase institutional capacity for HIV clinical investigation 2. Establish Weill Bugando/MITU as a sustainable training center for HIV clinical investigation. The ultimate goal is to prevent new HIV infections, provide effective HIV care, and improve HIV outcomes in Tanzania and East Africa. We will provide long-term training to fifteen outstanding clinician scientists to conduct patient-oriented HIV clinical investigation. We will primarily train physicians but will also train exceptional other clinicians (PharmD, DMD). We will train 10 PhDs, and 5 MS degree candidates. Tanzanian trainees will benefit from participation in 17 active research projects in five synergistic areas of HIV investigation including HIV prevention and vaccine research, implementation of HIV testing and treatment, women’s health, HIV related co-infections, and HIV and cardiovascular disease. We will also strengthen the PhD program in clinical investigation at Weill Bugando by introducing 4 new graduate courses in clinical investigation. Weill Cornell is committing institutional funds so that 4 of the best PhD graduates can have 2-year post-doctoral appointments as MITU research scientists after their Fogarty training. At the end of the 5-year training program, MITU will have a cadre of clinical investigators and a greater depth and breadth of externally funded HIV patient-oriented research. MITU/Weill Bugando will be a training hub for HIV clinical investigators in East Africa.

该计划将加强以患者为导向的医师科学家和艾滋病毒临床调查培训 坦桑尼亚西北部姆万扎的其他杰出临床医生。该计划建立在二十年的基础上 伙伴机构的合作和能力建设。坦桑尼亚的主要研究机构将 姆万扎干预试验组 (MITU)，隶属于坦桑尼亚国家医学研究所 研究（NIMR）。 MITU 成立于 2006 年，由 NIMR 和伦敦学派合作成立 卫生和热带医学学院（LSHTM）加强坦桑尼亚的艾滋病毒干预研究。米图 与同样位于姆万扎的威尔·布甘多医学院密切合作。威尔 Bugando 成立于 2003 年，旨在为坦桑尼亚西北部培训医生。 MITU 和 Weill Bugando 自威尔康奈尔医学院成立以来一直与该学院合作。 该研究培训计划旨在填补姆万扎的一个关键空白：坦桑尼亚医生需要 以患者为导向的艾滋病毒临床调查方面的严格培训。我们使用 NIH 的临床定义 调查是直接与 I 期、II 期或 II 期个体患者或患者群体相互作用的研究 III 临床试验、实用试验或形成性流行病学或行为研究，为临床做准备 试验。拟议培训计划的目标是： 1. 增加临床研究人员的数量 MITU，从而提高艾滋病毒临床研究的机构能力 2. 建立 Weill Bugando/MITU 作为艾滋病毒临床调查的可持续培训中心。最终目标是预防新的艾滋病毒 感染，提供有效的艾滋病毒护理，并改善坦桑尼亚和东非的艾滋病毒结果。 我们将为十五名优秀的临床科学家提供长期培训，以患者为中心进行艾滋病毒治疗 临床调查。我们将主要培训医生，但也会培训杰出的其他临床医生（药学博士、 DMD）。培养博士生10名，硕士生5名。坦桑尼亚学员将从参与中受益 参与艾滋病毒调查五个协同领域的 17 个活跃研究项目，包括艾滋病毒预防和 疫苗研究、艾滋病毒检测和治疗的实施、妇女健康、艾滋病毒相关的合并感染以及 艾滋病毒和心血管疾病。我们还将加强威尔临床研究的博士课程 Bugando 引入了 4 门新的临床研究研究生课程。威尔康奈尔承诺 机构基金，以便 4 名最优秀的博士毕业生能够获得为期 2 年的博士后任命 经过福格蒂培训的 MITU 研究科学家。 5年培训计划结束后，MITU将拥有 一支临床研究骨干队伍以及更深入、更广度的外部资助的以艾滋病患者为导向的研究 研究。 MITU/Weill Bugando 将成为东非艾滋病毒临床研究人员的培训中心。