Center for Interdisciplinary Study of Inflammatory Intestinal DIsorders (C-IID)

炎症性肠病跨学科研究中心 (C-IID)

• 批准号: 10374732
• 负责人: BANA JABRI
• 金额: $ 123万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10374732
• 关键词: Area; Automobile Driving; Basic Science; Biological Sciences; Biology; Biomedical Research; Chicago; Clinical; Clinical Sciences; Collaborations; Complex; Computational Science; Core Facility; Development; Digestive System Disorders; Direct Costs; Disease; Emerging Technologies; Environment; Environmental Risk Factor; Extramural Activities; Fostering; Foundations; Funding; Funding Opportunities; Genetic; Genomics; Goals; Health; Immune; Immunologic Factors; Immunology; Inflammation; Inflammatory; Inflammatory Bowel Diseases; Infrastructure; Interdisciplinary Study; Intestines; Investments; Lead; Life Cycle Stages; Metabolism; Midwestern United States; Mission; National Institute of Diabetes and Digestive and Kidney Diseases; Paper; Patient Care; Patients; Preventive treatment; Publications; Research; Research Infrastructure; Research Personnel; Resources; Science; Scientist; Services; Strategic vision; Structure; Sum; Talents; Technology; Technology Transfer; Therapeutic; Tissues; Training Programs; Translational Research; Translations; United States National Institutes of Health; Universities; analytical tool; base; biological development; career development; collaborative environment; cost effective; curative treatments; frontier; gut microbiome; high throughput technology; improved; innovation; interest; intestinal homeostasis; member; microbial; microbiome; microbiome research; multidisciplinary; new technology; next generation; novel diagnostics; patient oriented; patient oriented research; programs; response; therapeutic target; trend

PROJECT SUMMARY/ABSTRACT The main goal of the University of Chicago (UChicago) Digestive Diseases Research Core Center (DDRCC) for Interdisciplinary Study of Inflammatory Intestinal Disorders (C-IID) is to foster and facilitate interdisciplinary and innovative, patient-oriented, research in the field of complex inflammatory digestive diseases (DD), to understand and therapeutically exploit discoveries to improve the health of patients with DD. The UChicago C-IID is now in its 29th year, and, despite being a highly focused research program, has a multidisciplinary research base, with 46 full and 25 associate member investigators, and a total annual direct funding for DD that has increased by more than 40% since the last funding cycle, with $21.1 million of direct cost (not including funding from associate members). The ongoing CENTRAL HYPOTHESIS is that advances in care of patients with complex inflammatory diseases of the bowel requires a structure that empowers interdisciplinary clinical and discovery research investigating the mechanisms disrupting intestinal homeostasis and driving inflammation to identify therapeutic targets and foster translation of basic discoveries to development of new preventive and curative treatments. Taking-into-account the evolving scientific and technology advances and trends, and the interests of our members, we have re-aligned members around four C-IID cores that embrace four major interrelated research themes: Microbiome & Metabolism, Genetics, Genomics & Computation, Immune & Tissue response, and Translational & Clinical. Our OVERALL SPECIFIC AIMS are to: (i) build a highly collaborative, multidisciplinary team, (ii) identify and foster young investigators working in DD-related research, (iii) build a fully integrated translational research infrastructure with state-of-the-art core facilities and cutting-edge, high quality, and cost-effective services and resources, (iv) support a robust enrichment program, (v) promote interactions between the C-IID and other UChicago NIDDK centers and existing C-IID (especially with the Midwest DDRCC alliance). The C-IID has received tremendous institutional support as 1 of 5 priority areas designated for development by the Biological Sciences Division. The C-IID has successfully supported new investigators, but also drawn in talented scientists outside of the field of DD (8 now full members since 2015). Over the past two funding cycles, the P&F program has resulted in over $20.1M in extramural funds, or a 20 to 1 return- on-investment. Furthermore, 43% of the 322 publications acknowledging the C-IID for its support were coauthored by two or more C-IID members, indicating a high level of collaborative science. There was a 5-fold increase in the number of co-authored high impact papers (Impact factor>15) compared to the previous funding cycle. Thus, the C-IID has successfully met its goals of advancing the science and translation of discovery in inflammatory DD. The C-IID as a whole is greater than the sum of its parts. It provides strategic vision, cutting-edge, high quality, and cost-effective services and resources, and gives opportunity to current and next generation scientists to flourish in a highly collaborative and productive environment.

项目摘要/摘要 芝加哥大学（UCHICAGO）消化疾病研究核心中心（DDRCC）的主要目标 对于炎症性肠道疾病（C-IID）的跨学科研究是为了促进和促进 跨学科和创新，以患者为导向的，在复杂炎症消化领域的研究 疾病（DD），以了解和治疗利用发现以改善DD患者的健康状况。 Uchicago C-IID现在已经成立了29年，尽管是一项高度集中的研究计划，但仍有一个 多学科研究基础，有46位全面和25名员工调查员，每年的直接总数 自上次筹资周期以来，DD的资金增长了40％以上，直接成本为2110万美元 （不包括副成员的资金）。持续的中心假设是护理的进步 肠患有复杂炎症性疾病的患者需要一种结构，使跨学科的能力 临床和发现研究调查了破坏肠内稳态和驾驶的机制 炎症以识别治疗靶标和促进基本发现的翻译，以发展新的 预防和治疗方法。占领不断发展的科学和技术进步， 趋势以及我们成员的利益，我们重新安排了四个拥抱的C-IID核心 四个主要相互关联的研究主题：微生物组和代谢，遗传学，基因组学和计算， 免疫和组织反应，以及转化与临床。我们的总体具体目的是：（i）建造一个 高度协作，多学科团队，（ii）确定并培养与DD相关的年轻调查员 研究，（iii）通过最先进的核心设施建立了完全集成的翻译研究基础架构 尖端，高质量和具有成本效益的服务和资源，（iv）支持强大的丰富计划，（v） 促进C-IID与其他Uchicago Niddk中心与现有C-IID之间的互动（尤其是与 中西部DDRCC联盟）。 C-IID已获得大力的机构支持，因为5个优先领域中有1个 由生物科学部指定为开发。 C-IID成功支持了新的 调查人员，但也吸引了DD领域以外的才华横溢的科学家（自2015年以来现在有8名成员）。超过 在过去的两个资金周期中，P＆F计划导致了超过2010万美元的校外资金，或者有20至1个返回 - 投资。此外，在322个出版物中，有43％认可C-IID的支持。 由两个或多个C-IID成员，表明高水平的协作科学。增加了5倍 与以前的融资周期相比，共同作品的高影响力论文（影响因子> 15）数量。因此， C-IID成功地实现了炎症性DD中发现的科学和转化的目标。这 整个C-IID大于其部分的总和。它提供战略愿景，尖端，高质量和 具有成本效益的服务和资源，并为当前和下一代科学家提供了机会 一个高度协作和富有成效的环境。