The Interplay between Insomnia and Reward Processing in Risk for Depression

失眠与奖励处理之间的相互作用与抑郁风险的关系

• 批准号: 9788067
• 负责人: Yihan Irina Li
• 金额: $ 4.28万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-09-17 至 2021-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9788067
• 关键词: Adult; Affect; Affective; Age; Anhedonia; Area; Brain region; Child; Chronic Insomnia; Comorbidity; Cues; Depressed mood; Development; Disease remission; Drowsiness; Ecological momentary assessment; Economic Burden; Economics; Etiology; Event; Food; Functional disorder; Impaired cognition; Impairment; Impulsivity; Individual; Laboratories; Link; Literature; Longitudinal Studies; Maintenance; Maps; Mental Depression; Mental Health; Mental disorders; Methodology; Methods; Monitor; Moods; Motivation; Outcome; Persons; Play; Process; REM Sleep; Recurrence; Regulation; Research; Research Personnel; Rewards; Risk; Role; Sampling; Severities; Sleep; Sleep Architecture; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Sleeplessness; Stimulus; Symptoms; System; Testing; United States; Visit; Wakefulness; Work; aged; base; cognitive performance; depressive symptoms; emerging adult; examination questions; experience; falls; functional disability; innovation; insight; interest; mortality; physical conditioning; pleasure; recruit; response; reward anticipation; reward circuitry; reward processing; single episode major depressive disorder; sleep pattern; sleep quality; social; sustained attention; symptomatology; trait; vigilance; young adult

Project Summary/Abstract The link between both sleep problems and reward processing deficits have been well-established in depression; however, little research has examined the interplay of the two in conveying depression risk. Sleep problems are strongly implicated in not only the symptomatology of depression but also in its etiology and maintenance. Anhedonia, a hallmark of depression, is related to alterations in reward circuitry that leads to decreased reactivity to rewarding stimuli. Studies in healthy individuals have shown that decreased sleep disrupts reward processing, in particular by increasing reactivity to rewarding stimuli as well as decreasing motivation to pursue rewards. However, the role of insomnia in reward processing deficits associated with depression is less clear, and no studies have examined this relationship in the context of daily processes. In particular, although reward processing consists of unique and dissociable processes, comprising of anticipatory reward processing, consummatory reward processing, and motivation to recruit effort in the pursuit of reward, no study has attempted to delineate the relationship between insomnia and these separate reward- related components. Understanding of daily processes may be particularly critical in informing our understanding of the exact mechanisms through which risk for depression is conveyed. Thus, the current study proposes to characterize both between-person and within-person associations between insomnia and reward processing (Aim 1). Despite the large bodies of research on both reward-related deficits in depression and the role of sleep disturbance in depression and reward-processing, few attempts have been made to comprehensively examine the potential interplay between these two systems. Thus, this project will also examine how insomnia moderates the relationship between trait-level deficits in reward processing and momentary depressed mood (Aim 2). These aims will be tested using a sample of young adults aged 18-22 (N=145). The proposed study will include a baseline laboratory visit to assess trait-level reward processing function, chronic insomnia severity, and depressive symptoms, as well as utilize ecological momentary assessment and activity monitoring for 7 days to assess momentary depressed mood as well as daily objective sleep. The proposed project will advance the field by delineating the relationship between insomnia and multiple components of daily reward processes. Additionally, clarifying how insomnia and reward processing deficits interact with each other can provide a more unifying understanding of the development of depression risk.

项目总结/摘要 睡眠问题和奖赏处理缺陷之间的联系已经得到了很好的建立， 抑郁症;然而，很少有研究探讨了两者在传递抑郁症风险方面的相互作用。睡眠 这些问题不仅与抑郁症的病理学密切相关，而且与其病因学密切相关， 上维护快感缺失是抑郁症的一个标志，它与奖赏回路的改变有关， 对奖励刺激的反应性降低。对健康人的研究表明，睡眠减少 扰乱奖励处理，特别是通过增加对奖励刺激的反应以及减少 追求奖励的动机。然而，失眠在奖赏处理缺陷中的作用与 抑郁症不太清楚，没有研究在日常过程的背景下检查这种关系。在 特别是，虽然奖励处理由独特的和可分离的过程组成，包括 预期性奖励加工、完善性奖励加工和在追求中招募努力的动机 关于奖励，没有研究试图描述失眠和这些单独的奖励之间的关系- 相关组件。了解日常过程可能对我们的信息特别重要。 了解抑郁症风险传递的确切机制。因此，当前的研究 提出的特点都人与人之间的关联失眠和奖励 处理（目标1）。尽管对抑郁症中与奖励相关的缺陷和抑郁症中与奖励相关的缺陷进行了大量的研究， 睡眠障碍在抑郁症和奖励过程中的作用，很少有人试图 全面研究这两个系统之间的潜在相互作用。因此，该项目还将 研究失眠如何调节奖励处理中的特质水平缺陷与 情绪低落（目标2）。这些目标将以18-22岁的年轻人为样本进行测试 （N=145）。拟议的研究将包括一个基线实验室访问，以评估特质水平的奖励处理 功能，慢性失眠的严重程度，和抑郁症状，以及利用生态瞬间 评估和活动监测7天，以评估瞬时抑郁情绪以及日常目标 睡吧该项目将通过描绘失眠与抑郁症之间的关系来推进该领域的研究。 日常奖励流程的多个组成部分。此外，阐明失眠和奖励处理 缺陷相互作用可以提供对抑郁症发展的更统一的理解 风险