Cancer Adoptive Cell Therapy (Can-ACT) Network Coordinating Center at Mayo Clinic

梅奥诊所癌症过继细胞治疗 (Can-ACT) 网络协调中心

• 批准号: 10730805
• 负责人: Yan W. Asmann
• 金额: $ 48.03万
• 依托单位: MAYO CLINIC ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10730805
• 关键词: Administrative Coordination; Administrative Supplement; Adoptive Cell Transfers; Adult; Animal Model; Area; Bioinformatics; Biological; Biological Specimen Banks; Biometry; Cancer Center; Cell Therapy; Cells; Childhood; Clinic; Clinical; Clinical Research; Clinical Trials; Collaborations; Collection; Communication; Communities; Data; Data Collection; Data Management Resources; Data Science; Data Security; Development; Elements; Foundations; Funding; Human; Individual; Industry; Infrastructure; Institution; Leadership; Learning; Malignant Neoplasms; Multicenter Trials; Oncology; Patients; Policies; Positioning Attribute; Process; Reagent; Research; Research Personnel; Resources; Solid Neoplasm; Specimen; Standardization; Structure; Testing; Therapeutic; Therapeutic Agents; Translational Research; Work; anticancer research; biobank; clinical translation; data harmonization; data management; data sharing; data submission; design; early phase clinical trial; electronic data; experience; innovation; interest; manufacture; meetings; member; novel therapeutics; operation; pre-clinical; pre-clinical research; preclinical development; preclinical study; programs; research study; synergism; treatment response; web site; working group

PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of scientific and clinical needs of the funded UG3/UH3 centers comprising the Cancer Adoptive Cellular Therapeutics (Can-ACT) Network. The Network Coordinating Center at Mayo Clinic (NCC-MC) will serve as the administrative hub and coordinating center for all network-related trials and projects. This will include multiple aspects of the functioning of this network, including the administrative and scientific coordination of the Can-ACT Network. The administrative coordination will include (a) providing leadership and facilitating interactions across the network, (b) providing administrative infrastructure to support the activities of the Can-ACT Network, and (c) the coordination of the restricted collaborative funds and administrative supplements for the network. Scientific coordination of this network will include several different critical components, including (a) identifying and establishing strategies for facilitating reagent and specimen sharing, (b) identification and harmonization of process development and manufacturing steps for cell product management and utilization for the functioning of the network between centers and the ICN Core, (c) biostatistical support and collaboration for preclinical and clinical research studies and centralized data management and shared data governance, and (d) bioinformatics and data science support and collaboration. The infrastructure, expertise, and experience of the individuals at Mayo Clinic with national coordination of translational and clinical research is extensive, making this group well-positioned to function as an outstanding coordinating center for the Can-ACT Network. The leadership of this proposed coordinating center brings with them complementary and deep experience and background across these key aims, and they have worked extensively with multi-institutional trials, consortia, and networks as well as cooperative groups in research leadership, trial coordination and implementation, data structures, and importantly development of SOPs and guidance for newly formed collaborative research networks across multiple institutions. Beyond the experience and expertise, the NCC-MC also leverages institutional infrastructure and resources to adapt and evolve as the Can-ACT Network develops and grows through the expected and necessary collaborations across all UG3/UH3 centers and project leaders.

项目概要/摘要-网络协调中心 网络协调中心将促进并负责全网络的协调， 协调受资助的UG 3/UH 3中心的科学和临床需求，包括癌症预防中心 细胞治疗（Can-ACT）网络。马约诊所的网络协调中心（NCC-MC）将 作为所有网络相关试验和项目的行政枢纽和协调中心。这将 包括该网络运作的多个方面，包括行政和科学方面， 协调加拿大-ACT网络。行政协调将包括（a）提供领导， 促进整个网络的互动，（B）提供行政基础设施，以支持 （c）协调有限的合作基金和行政管理 网络的补充。该网络的科学协调将包括几个不同的关键 （a）确定和制定促进试剂和样本共享的战略， (b)电池产品工艺开发和制造步骤的识别和协调 管理和利用中心与ICN核心之间的网络功能， 为临床前和临床研究和集中数据提供生物统计支持和协作 管理和共享数据治理;（d）生物信息学和数据科学支持与合作。 马约诊所的基础设施、专业知识和个人经验， 翻译和临床研究是广泛的，使这个小组处于有利地位，作为一个杰出的 Can-ACT网络的协调中心。这个拟议的协调中心的领导层带来了 他们在这些关键目标方面的互补和深厚的经验和背景，他们已经工作了 广泛与多机构试验，财团和网络以及研究合作小组 领导、试验协调和实施、数据结构，以及重要的SOP的制定， 为跨多个机构新成立的合作研究网络提供指导。超越体验 和专业知识，NCC-MC还利用机构基础设施和资源， Can-ACT网络通过所有人的预期和必要的合作来发展和成长 UG 3/UH 3中心和项目负责人。