Cancer Adoptive Cell Therapy (Can-ACT) Network Coordinating Center at Mayo Clinic

项目总结/摘要-网络协调中心 网络协调中心(NCC)将促进和负责全网协调和 协调由UG3/UH3资助中心组成的癌症收养中心的科学和临床需求 细胞治疗(CAN-ACT)网络。梅奥诊所的网络协调中心(NCC-MC)将 作为所有与网络相关的试验和项目的行政枢纽和协调中心。这将是 包括该网络运作的多个方面，包括行政和科学 协调CAN-ACT网络。行政协调将包括：(A)提供领导和 促进整个网络的互动，(B)提供行政基础设施，以支持 CAN-ACT网络，以及(C)有限合作资金和行政管理的协调 网络的补充品。该网络的科学协调将包括几个不同的关键 各组成部分，包括(A)确定和制定促进试剂和标本共享的战略； (B)确定和统一电池产品的工艺开发和制造步骤 管理和利用各中心和ICN核心之间的网络功能，(C) 为临床前和临床研究研究及集中数据提供生物统计学支持和协作 管理和共享数据治理，以及(D)生物信息学和数据科学支助与协作。 梅奥诊所的基础设施、专业知识和经验与国家协调 广泛的翻译和临床研究，使这一群体处于有利地位，能够作为杰出的 CAN-ACT网络协调中心。这个拟议中的协调中心的领导层带来了 他们在这些关键目标上相互补充和深入的经验和背景，他们已经工作 广泛地与多机构试验、联盟和网络以及研究合作小组合作 领导、试验协调和实施、数据结构，以及重要的SOP和 为跨多个机构的新形成的协作研究网络提供指导。超越体验 和专业知识，NCC-MC还利用机构基础设施和资源来适应和发展 CAN-ACT网络通过所有领域预期和必要的协作来发展和壮大 UG3/UH3中心和项目负责人。

PROJECT SUMMARY/ABSTRACT – NETWORK COORDINATING CENTER The Network Coordinating Center (NCC) will facilitate and be responsible for network-wide coordination and harmonization of scientific and clinical needs of the funded UG3/UH3 centers comprising the Cancer Adoptive Cellular Therapeutics (Can-ACT) Network. The Network Coordinating Center at Mayo Clinic (NCC-MC) will serve as the administrative hub and coordinating center for all network-related trials and projects. This will include multiple aspects of the functioning of this network, including the administrative and scientific coordination of the Can-ACT Network. The administrative coordination will include (a) providing leadership and facilitating interactions across the network, (b) providing administrative infrastructure to support the activities of the Can-ACT Network, and (c) the coordination of the restricted collaborative funds and administrative supplements for the network. Scientific coordination of this network will include several different critical components, including (a) identifying and establishing strategies for facilitating reagent and specimen sharing, (b) identification and harmonization of process development and manufacturing steps for cell product management and utilization for the functioning of the network between centers and the ICN Core, (c) biostatistical support and collaboration for preclinical and clinical research studies and centralized data management and shared data governance, and (d) bioinformatics and data science support and collaboration. The infrastructure, expertise, and experience of the individuals at Mayo Clinic with national coordination of translational and clinical research is extensive, making this group well-positioned to function as an outstanding coordinating center for the Can-ACT Network. The leadership of this proposed coordinating center brings with them complementary and deep experience and background across these key aims, and they have worked extensively with multi-institutional trials, consortia, and networks as well as cooperative groups in research leadership, trial coordination and implementation, data structures, and importantly development of SOPs and guidance for newly formed collaborative research networks across multiple institutions. Beyond the experience and expertise, the NCC-MC also leverages institutional infrastructure and resources to adapt and evolve as the Can-ACT Network develops and grows through the expected and necessary collaborations across all UG3/UH3 centers and project leaders.