Kentucky Center for Clinical and Translational Science

肯塔基州临床和转化科学中心

• 批准号: 10733214
• 负责人: Philip A Kern
• 金额: $ 17.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-08-15 至 2026-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10733214
• 关键词: Address; Adolescence; Adult; Age; Air Pollution; Appalachian Region; Automobile Driving; Award; Back; Body mass index; Cardiovascular system; Child; Childhood; Clinic Visits; Clinical Research; Clinical Sciences; Clinical Trials; Collaborations; Collection; Communication; Communities; Community Healthcare; Development; Diabetes Mellitus; Diagnosis; Discipline; Disparity; Distress; Drowsiness; Economics; Elderly; Environment; Environmental Exposure; Environmental Pollutants; Environmental Risk Factor; Epidemic; Epidemiology; Exposure to; Fostering; Frequencies; Future; Generations; Glycosylated hemoglobin A; Goals; Hair; Health; Health Disparities Research; Health Status; Healthcare; Heavy Metals; Home; Individual; Institution; Integrated Health Care Systems; Joints; Kentucky; Lead; Leg Cramp; Letters; Life Cycle Stages; Link; Literature; Longevity; Malignant Neoplasms; Measurement; Measures; Metal exposure; Metals; Mission; Modeling; Neurosciences; Obesity; Occupational; Outcome; Outcome Study; Parasomnias; Participant; Patient Self-Report; Pediatric cohort; Persons; Phase; Population; Positioning Attribute; Prevalence; Process; Quality of life; Questionnaires; Recommendation; Recording of previous events; Reporting; Research; Role; Rural; Rural Appalachia; Rural Community; Rural Health; School-Age Population; Science; Serum; Sleep; Sleep Apnea Syndromes; Sleep Deprivation; Sleep Disorders; Sleep disturbances; Smoke; Smoking; Snoring; Statistical Methods; Structure of nail of toe; Substance abuse problem; Symptoms; Syndrome; Translational Research; Underserved Population; United States; Universities; Update; West Virginia; Whole Blood; Work; cardiometabolism; clinical center; cohort; community based participatory research; community engagement; deciduous tooth; diversity and inclusion; early life exposure; environmental tobacco smoke; environmental tobacco smoke exposure; health disparity; health equity; health inequalities; improved; innovation; new technology; obesity in children; obesity risk; opioid abuse; parent grant; patient engagement; poor sleep; preadolescence; programs; rural area; rural dwellers; sleep behavior; sleep health; sleep onset; social factors; urinary; web site

PARENT GRANT PROJECT SUMMARY - OVERALL The University of Kentucky (UK) Center for Clinical and Translational Science (CCTS) has created an integrated home for clinical and translational research which promotes scientific progress and discoveries at every phase of the translational continuum. The CCTS has partnered with communities in Central Appalachia to address multiple generations of recalcitrant health inequities related in part to the economic distress of rural communities. The CCTS has fundamentally transformed UK and Central Appalachia through the development of strong academic-community research networks and collaborations within the CTSA consortium. Appalachian health disparities are further magnified by the opioid and substance abuse epidemic, which has greatly impacted eastern Kentucky and West Virginia. The strong UK research portfolio puts the UK CCTS in an optimal position to lead local, regional and national research efforts focused on rural health inequities. The aligned missions of UK, UK HealthCare and the CCTS focus on achieving health equity by engaging in highly innovative, collaborative and dynamic translational research to address rural health needs. The CCTS will continue to educate the translational workforce of the future, engage rural communities in translational and bi-directional team science and work with the national network to advance transdisciplinary research and clinical trials through the following Specific Aims: 1) develop, innovate and transform our research environment to promote impactful science and discovery within our integrated health care system to meet the unique health needs of Central Appalachian residents; 2) lead institutional innovation in the delivery of impactful clinical and translational research that covers the lifespan, fully engages the community and embraces team science; 3) catalyze an efficient, university-wide clinical trials organization which adds value to the CTSA consortium by engaging participants from rural Central Appalachia; and 4) foster and enhance a workforce characterized by diversity and inclusivity across all translational science disciplines and populations. The UK CTSA hub is uniquely positioned in the National CTSA Consortium to foster novel technologies, team science, clinical trial start-up and cutting-edge translational research across the lifespan with a focus on rural communities. We have a particular focus on the Central Appalachian community, a rural area with many of the highest levels of health disparities in the nation. This focus will ultimately elevate the health and quality of life of rural communities throughout the United States.

项目概况-总体 肯塔基州大学（英国）临床和转化科学中心（CCTS）创建了一个 临床和转化研究的综合之家，促进科学进步和发现， 平移连续体的每一个阶段CCTS与阿巴拉契亚中部的社区合作 解决几代人之间难以解决的卫生不公平问题，部分原因是农村人口的经济困境， 社区. CCTS从根本上改变了英国和中央阿巴拉契亚通过发展 强大的学术社区研究网络和CTSA联盟内的合作。 阿帕拉契亚的健康差距因阿片类药物和药物滥用的流行而进一步扩大， 严重影响了肯塔基州东部和西弗吉尼亚州。强大的英国研究组合使英国CCTS成为 领导地方、区域和国家重点关注农村卫生不平等问题的研究工作的最佳位置。 联合王国、联合王国卫生保健和CCTS的统一使命侧重于通过参与以下活动实现卫生公平： 高度创新、协作和动态的转化研究，以满足农村卫生需求。持续关连交易 将继续教育未来的翻译劳动力，让农村社区参与翻译， 双向团队科学和工作与国家网络，以推进跨学科的研究， 临床试验通过以下具体目标：1）发展，创新和改造我们的研究环境 在我们的综合医疗保健系统内促进有影响力的科学和发现，以满足独特的健康需求。 阿巴拉契亚中部居民的需求; 2）领导机构创新，提供有影响力的临床和 涵盖生命周期的转化研究，充分参与社区并拥抱团队科学; 3） 促进一个有效的，大学范围内的临床试验组织，通过以下方式为CTSA联盟增加价值 吸引来自阿巴拉契亚中部农村地区的参与者;以及4）培养和加强一支具有以下特点的劳动力队伍： 所有转化科学学科和人群的多样性和包容性。英国CTSA中心是 在国家CTSA联盟中具有独特的地位，以促进新技术，团队科学，临床试验 在整个生命周期内开展初创和尖端的转化研究，重点是农村社区。我们 特别关注阿巴拉契亚中部社区，这是一个农村地区，有许多最高水平的 国家的健康差距。这一重点将最终提高农村人口的健康和生活质量， 美国各地的社区。

项目成果

Social Determinants of Health Factors for Gene-Environment COVID-19 Research: Challenges and Opportunities.

• DOI: 10.1002/ggn2.202100056
• 发表时间: 2022-06
• 期刊: Advanced genetics (Hoboken, N.J.)
• 作者: Phuong, Jimmy;Riches, Naomi O;Madlock-Brown, Charisse;Duran, Deborah;Calzoni, Luca;Espinoza, Juan C;Datta, Gora;Kavuluru, Ramakanth;Weiskopf, Nicole G;Ward-Caviness, Cavin K;Lin, Asiyah Yu
• 通讯作者: Lin, Asiyah Yu

Abuse-Deterrent Opioids: A Survey of Physician Beliefs, Behaviors, and Psychology.

• DOI: 10.1007/s40122-021-00343-z
• 发表时间: 2022-03
• 期刊: Pain and therapy
• 影响因子: 4
• 作者: Dasgupta N;Brown JR;Nocera M;Lazard A;Slavova S;Freeman PR
• 通讯作者: Freeman PR

A survey of the barriers associated with academic-based cancer research commercialization.

• DOI: 10.1371/journal.pone.0072268
• 发表时间: 2013
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Vanderford NL;Weiss LT;Weiss HL
• 通讯作者: Weiss HL

Reported Barriers to Hepatitis C Treatment among Pregnant and Early-Parenting Mothers Undergoing Substance Use Disorder Treatment in One U.S. State.

• DOI: 10.3390/idr14010001
• 发表时间: 2021-12-22
• 期刊: Infectious disease reports
• 影响因子: 3.2
• 作者: Adekunle AD;Harp KL;Al-Abdali ZG;Critchfield AS;Barnhart S;Winter KT
• 通讯作者: Winter KT

Vancomycin Dosing Practices among Critical Care Pharmacists: A Survey of Society of Critical Care Medicine Pharmacists.

• DOI: 10.1177/1178633720952078
• 发表时间: 2020
• 期刊: Infectious diseases
• 影响因子: 5.8
• 作者: Flannery AH;Hammond DA;Oyler DR;Li C;Wong A;Smith AP;Yeo QM;Chaney W;Pfaff CE;Plewa-Rusiecki AM;Juang P
• 通讯作者: Juang P