Mechanisms for Activation of Beige Adipose Tissue in Humans; Supplement

人类米色脂肪组织的激活机制；

• 批准号: 10630687
• 负责人: Philip A Kern
• 金额: $ 47.25万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630687
• 关键词: Academic Medical Centers; Address; Adipose tissue; Adult; Americas; Area; Autoantibodies; Autoimmunity; Beta Cell; Body mass index; C-Peptide; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 severity; Caring; Child; Childhood; Clinical; Clinical Data; Code; Communities; Data; Data Analyses; Data Set; Data Sources; Databases; Development; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis; Electronic Health Record; Endocrinologist; Epidemiologist; Epidemiology; Ethnic Origin; Glucocorticoids; Glycosylated hemoglobin A; Health; Healthcare; High Prevalence; Human; Incidence; Individual; Infection; Inflammation; Inflammatory; Inpatients; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Kentucky; Laboratories; Link; Lung; Medicaid; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outpatients; Patients; Persons; Pharmaceutical Preparations; Population; Process; Race; Registries; Reporting; Resources; Retrospective cohort; Risk; Rural; SARS-CoV-2 infection; Severities; Severity of illness; Test Result; United States; Universities; Vaccination; Vaccines; Vital Statistics; autoimmune pathogenesis; beneficiary; clinically relevant; coronavirus disease; design; diabetogenic; health disparity; high risk; improved; marginalized population; post SARS-CoV-2 infection; response; severe COVID-19; sociodemographics; socioeconomic disadvantage; study population; trend; vaccine acceptance

Abstract This proposal is a supplement to “Mechanisms for Activation of Beige Adipose Tissue in Humans”, R01 DK124626 in response to NOT-DK-22-017. The supplement is titled: “Impact of COVID-19 on diabetes incidence and severity in the United States and Kentucky”. There is mounting evidence that COVID-19 is associated with increased risk of incident diabetes. This supplement assembles a team of Endocrinologists, Pulmonary intensivists, Informaticians, Epidemiologists and Statisticians who will perform a detailed analysis of linked comprehensive data sets to identify key factors (and putative mechanisms) that relate COVID-19 infection to incident diabetes. In the proposed project, the team will explore the COVID and incident diabetes relationship among adults and children using three distinct data sources: 1) a large, nationwide database of commercially insured individuals (MarketScan), 2) Kentucky state Medicaid claims data, and 3) detailed clinical data from the University of Kentucky HealthCare (UKHC) electronic health record (EHR). Our overall hypothesis is that new onset diabetes is greater in subjects with the most severe COVID infections and in areas of Kentucky with the health disparities. To address these hypotheses, we propose the following Specific Aims, 1) to compare population-level trends in the incidence and severity of new onset diabetes during the COVID-19 pandemic (2020-2021) to historical data (2018-2019) in three distinct study populations, and 2) to examine the association between COVID infection and incident diabetes at the individual level using a matched, retrospective cohort design. We will also examine factors that modify this association, including severity of diabetes, diabetes type, sociodemographics (age, race/ethnicity, region), BMI, severity of COVID infection, vaccination status, timing of diabetes onset following COVID-19, and overall health from diagnosis codes, lab values, medications and clinical notes. In summary, this study will examine the relationship between COVID-19 and incident diabetes in very different populations, including rural Kentucky, which has high health disparities. In addition, we will examine the effects of prior vaccination, which may lessen the severity of disease and decrease diabetes incidence.

抽象的 该建议是“在人类中激活米色脂肪组织的机制”的补充，R01 DK124626响应于NOT-DK-22-017。该补品的标题为：“ Covid-19对糖尿病的影响 美国和肯塔基州的发病率和严重程度”。 有越来越多的证据表明Covid-19与出现糖尿病的风险增加有关。这 补充汇集了一个内分泌学家，肺强化主义者，知情者，流行病学家和 统计学家将对链接的综合数据集进行详细分析，以识别关键因素（和 推定的机制）将COVID-19感染与入射糖尿病相关的机制。在拟议的项目中，团队 将使用三个不同的数据探索成人和儿童之间的糖尿病关系 资料来源：1）商业保险人的大型国家数据库（MarketScan），2）肯塔基州 医疗补助索赔数据和3）肯塔基大学医疗保健大学（UKHC）的详细临床数据 电子健康记录（EHR）。我们的总体假设是，在患有的受试者中，新的糖尿病更大 最严重的共同感染和肯塔基州的健康差异。解决这些 假设，我们提出以下特定目标，1）比较事件中的人口级趋势 与历史数据（2018-2019）期间，新发作糖尿病（2020-2021）期间的新发作糖尿病的严重程度和严重程度 在三个不同的研究人群中，以及2）检查互联感染与入射之间的关联 使用匹配的回顾性队列设计，在单个级别的糖尿病。我们还将研究 修改这种关联，包括糖尿病的严重程度，糖尿病类型，社会人口统计学（年龄，种族/种族， 区域），BMI，共vid感染的严重程度，疫苗接种状况，Covid-19之后的糖尿病发作时间和 诊断代码，实验室价值，药物和临床笔记的总体健康状况。总而言之，这项研究将 检查截然不同的人群中的Covid-19与入射糖尿病之间的关系，包括粗糙 肯塔基州的健康差异很高。此外，我们将研究先前疫苗接种的影响，该疫苗接种的影响 可能会减轻疾病的严重程度并降低糖尿病的发病率。