Mechanisms for Activation of Beige Adipose Tissue in Humans; Supplement

人类米色脂肪组织的激活机制；

• 批准号: 10630687
• 负责人: Philip A Kern
• 金额: $ 47.25万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-12-01 至 2025-11-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10630687
• 关键词: Academic Medical Centers; Address; Adipose tissue; Adult; Americas; Area; Autoantibodies; Autoimmunity; Beta Cell; Body mass index; C-Peptide; COVID-19; COVID-19 impact; COVID-19 pandemic; COVID-19 severity; Caring; Child; Childhood; Clinical; Clinical Data; Code; Communities; Data; Data Analyses; Data Set; Data Sources; Databases; Development; Diabetes Mellitus; Diabetic Ketoacidosis; Diagnosis; Electronic Health Record; Endocrinologist; Epidemiologist; Epidemiology; Ethnic Origin; Glucocorticoids; Glycosylated hemoglobin A; Health; Healthcare; High Prevalence; Human; Incidence; Individual; Infection; Inflammation; Inflammatory; Inpatients; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Kentucky; Laboratories; Link; Lung; Medicaid; Non-Insulin-Dependent Diabetes Mellitus; Obesity; Outpatients; Patients; Persons; Pharmaceutical Preparations; Population; Process; Race; Registries; Reporting; Resources; Retrospective cohort; Risk; Rural; SARS-CoV-2 infection; Severities; Severity of illness; Test Result; United States; Universities; Vaccination; Vaccines; Vital Statistics; autoimmune pathogenesis; beneficiary; clinically relevant; coronavirus disease; design; diabetogenic; health disparity; high risk; improved; marginalized population; post SARS-CoV-2 infection; response; severe COVID-19; sociodemographics; socioeconomic disadvantage; study population; trend; vaccine acceptance

Abstract This proposal is a supplement to “Mechanisms for Activation of Beige Adipose Tissue in Humans”, R01 DK124626 in response to NOT-DK-22-017. The supplement is titled: “Impact of COVID-19 on diabetes incidence and severity in the United States and Kentucky”. There is mounting evidence that COVID-19 is associated with increased risk of incident diabetes. This supplement assembles a team of Endocrinologists, Pulmonary intensivists, Informaticians, Epidemiologists and Statisticians who will perform a detailed analysis of linked comprehensive data sets to identify key factors (and putative mechanisms) that relate COVID-19 infection to incident diabetes. In the proposed project, the team will explore the COVID and incident diabetes relationship among adults and children using three distinct data sources: 1) a large, nationwide database of commercially insured individuals (MarketScan), 2) Kentucky state Medicaid claims data, and 3) detailed clinical data from the University of Kentucky HealthCare (UKHC) electronic health record (EHR). Our overall hypothesis is that new onset diabetes is greater in subjects with the most severe COVID infections and in areas of Kentucky with the health disparities. To address these hypotheses, we propose the following Specific Aims, 1) to compare population-level trends in the incidence and severity of new onset diabetes during the COVID-19 pandemic (2020-2021) to historical data (2018-2019) in three distinct study populations, and 2) to examine the association between COVID infection and incident diabetes at the individual level using a matched, retrospective cohort design. We will also examine factors that modify this association, including severity of diabetes, diabetes type, sociodemographics (age, race/ethnicity, region), BMI, severity of COVID infection, vaccination status, timing of diabetes onset following COVID-19, and overall health from diagnosis codes, lab values, medications and clinical notes. In summary, this study will examine the relationship between COVID-19 and incident diabetes in very different populations, including rural Kentucky, which has high health disparities. In addition, we will examine the effects of prior vaccination, which may lessen the severity of disease and decrease diabetes incidence.

摘要 本提案是对“人类米色脂肪组织激活机制”R 01的补充 DK 124626响应NOT-DK-22-017。该增刊的标题是：“COVID-19对糖尿病的影响 美国和肯塔基州的发病率和严重程度”。 越来越多的证据表明，COVID-19与糖尿病发病风险增加有关。这 补充汇集了一个团队的内分泌学家，肺重症监护医师，信息学家，流行病学家和 统计学家将对相关的综合数据集进行详细分析，以确定关键因素（以及 假定的机制），将COVID-19感染与糖尿病事件联系起来。在这个项目中，团队 将使用三个不同的数据来探索成人和儿童之间的COVID和糖尿病发病率之间的关系 资料来源：1）一个大型的全国性商业保险个人数据库（MarketScan），2）肯塔基州 Medicaid索赔数据，以及3）来自肯塔基州医疗保健大学（UKHC）的详细临床数据 电子健康记录（EHR）。我们的总体假设是，新发糖尿病患者中， 最严重的COVID感染和健康差距最大的肯塔基州地区。解决这些 假设，我们提出了以下具体目标，1）比较人群水平的发病率趋势， 2019冠状病毒病大流行期间（2020-2021年）新发糖尿病的严重程度与历史数据（2018-2019年） 在三个不同的研究人群中，2）检查COVID感染与事件之间的关联 糖尿病在个人水平上使用匹配，回顾性队列设计。我们还将研究 修改这种关联，包括糖尿病的严重程度、糖尿病类型、社会人口统计学（年龄，种族/民族， 地区）、BMI、COVID感染的严重程度、疫苗接种状况、COVID-19后糖尿病发作的时间，以及 从诊断代码，实验室值，药物和临床记录的整体健康状况。总之，这项研究将 研究COVID-19与包括农村在内的不同人群中糖尿病发病率之间的关系 肯塔基州，那里有很高的健康差距。此外，我们还将检查先前接种疫苗的效果， 可以减轻疾病的严重程度，降低糖尿病的发病率。