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Cell-cell communications create robust collective immunological responses

Cell-cell communications create robust collective immunological responses
细胞间通讯产生强大的集体免疫反应
批准号：
10014790
负责人：
Gregoire Altan-Bonnet
金额：
$28.92万
依托单位：
DIVISION OF BASIC SCIENCES - NCI
依托单位国家：
美国
项目类别：
财政年份：
--
资助国家：
美国
项目状态：
未结题
起止时间：
至
来源：
https://reporter.nih.gov/project-details/10014790
关键词：
AntigensAntitumor ResponseAutoantigensCD4 Positive T LymphocytesCD8-Positive T-LymphocytesCell CommunicationCell modelCellsCessation of lifeCuesFeedbackFrequenciesGoalsHeterogeneityImmune responseImmunityIndividualInterleukin-2LawsOutputPathway interactionsPopulationPredispositionProductionPropertyReactionSignal TransductionStimulusT cell responseT-Cell ActivationT-LymphocyteTimeTissuesTranslatingTumor AntigensWorkYanganaloganti-tumor immune responseantigen-specific T cellscytokineexhaustionparacrinequantumresponseself organizationtooltumor

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英文摘要
We developed quantitative models of the cell-to-cell communications via cytokines amongst population of T lymphocytes. Our goal is to understand how T cells self-organize to decide their cell fate (e.g. between quiescence -tolerance- and death/proliferation -responses). At a fundamental level, we developed theoretical tools to analyze the heterogeneity and synchronicity of T cell responses in dense tissues. In the context of responses to tumor, we found that a critical mass of T cells existed to drive tumor rejection. Additional work is being carried out to dissect quantitatively how T cell decide collectively between tumor rejection and tumor tolerance.
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Endogenous Heterogeneity of Signaling Pathways in Cancer
  • 批准号：
    8181559
  • 项目类别：
  • 资助金额：
    $15.03万
  • 财政年份：
    2010
  • 负责人：
    Gregoire Altan-Bonnet
  • 依托单位：
    SLOAN-KETTERING INST CAN RESEARCH
Variability of Cellular Responses to Growth Factors and Drugs During Tumorgenesis
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    8181539
  • 项目类别：
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  • 财政年份：
    2010
  • 负责人：
    Gregoire Altan-Bonnet
  • 依托单位：
    SLOAN-KETTERING INST CAN RESEARCH
Quantitative modeling of the phenotypic variability of individual T cells and the
  • 批准号：
    8306678
  • 项目类别：
  • 资助金额：
    $48.89万
  • 财政年份：
    2009
  • 负责人：
    Gregoire Altan-Bonnet
  • 依托单位：
    SLOAN-KETTERING INST CAN RESEARCH
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  • 批准号：
    8555278
  • 项目类别：
  • 资助金额：
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  • 财政年份：
    2009
  • 负责人：
    Gregoire Altan-Bonnet
  • 依托单位：
    DANA-FARBER CANCER INST
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