Center for Label-free Imaging and Multiscale Biophotonics (CLIMB)

无标记成像和多尺度生物光子学中心 (CLIMB)

• 批准号: 10705138
• 负责人: Stephen A Boppart
• 金额: $ 140.11万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-30 至 2027-06-20
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10705138
• 关键词: Address; Adoption; Biological Markers; Biophotonics; Books; Chemicals; Clinic; Clinical Research; Clinical Trials; Collaborations; Communities; Contrast Media; Cost Sharing; Decision Making; Education; Educational Materials; Educational workshop; Enrollment; Environment; Equipment; Evaluation; Faculty; Feedback; Fellowship; Funding; Healthcare; Human; Image; Imaging technology; Label; Lead; Malignant Neoplasms; Microscopy; Minority Groups; Monitor; Neurodegenerative Disorders; Optical Coherence Tomography; Optics; Phase; Postdoctoral Fellow; Procedures; Process; Productivity; Program Development; Research; Research Personnel; Resources; Schools; Series; Specificity; Specimen; Students; Technology; Time; Training; Training Programs; Translating; Underrepresented Populations; Writing; clinical application; clinical practice; commercialization; contrast imaging; deep learning; diversity and inclusion; expectation; experience; imaging modality; improved; in vivo; in vivo imaging; innovation; member; multimodality; new technology; next generation; open source; operation; optical imaging; point of care; programs; residence; service programs; synergism; technology research and development; technology training; tool; webinar

SUMMARY The Center for Label-free Imaging and Multiscale Biophotonics (CLIMB) develops cutting-edge optical and computational imaging technologies for addressing grand challenges in biomedicine, including cancer and neurodegenerative diseases. Building upon the recent advances in interferometric, nonlinear, chemical, and computational imaging at UIUC, CLIMB will establish a unique technology and training hub for cutting-edge biophotonics. Specifically, the three Technology Research and Development (TRD) projects will synergize expertise in multimodal and nonlinear imaging from the Boppart group, computational imaging from the Anastasio group, and quantitative phase imaging, from the Popescu group, to translate new technology from lab-to-clinic and point-of-care settings. The unifying concept for the technologies developed at CLIMB is the ability to extract quantitative biomarkers from specimens using intrinsic contrast imaging, i.e., label-free. These technologies will be pushed for the first time to handheld configurations to allow in-vivo and point-of-care (POC) operation. We developed a rigorous and inclusive technology training and dissemination plan, as well as a comprehensive educational program to prepare the next generation of biophotonics researchers for excelling in label-free imaging.

总结 无标记成像和多尺度生物光子学中心（CLIMB）开发了尖端的光学和 计算成像技术，用于应对生物医学的重大挑战，包括癌症和 神经退行性疾病基于干涉、非线性、化学和物理等领域的最新进展， 计算成像在UIUC，CLIMB将建立一个独特的技术和培训中心，为尖端 生物光子学具体而言，这三个技术研究和发展项目将发挥协同作用， Boppart集团在多模态和非线性成像方面的专业知识， Anastasio集团和Popescu集团的定量相位成像，将新技术从 实验室到诊所和护理点设置。CLIMB开发的技术的统一概念是 使用固有对比度成像从样本中提取定量生物标志物的能力，即，无标签这些 技术将首次被推向手持配置，以允许体内和即时护理（POC） 操作 我们制定了严格和包容的技术培训和传播计划，以及全面的 教育计划，以准备下一代生物光子学研究人员在无标签方面的卓越表现 显像